دورية أكاديمية
Association of sex hormone binding globulin with gestational age and parity in gestational diabetes mellitus.
| العنوان: | Association of sex hormone binding globulin with gestational age and parity in gestational diabetes mellitus. |
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| المؤلفون: | Siddiqui K; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., George TP; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Joy SS; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Nawaz SS; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Apr; Vol. 35 (8), pp. 1433-1438. Date of Electronic Publication: 2020 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Diabetes, Gestational*, Cross-Sectional Studies ; Female ; Gestational Age ; Humans ; Parity ; Pregnancy ; Risk Factors ; Sex Hormone-Binding Globulin/analysis ; Sex Hormone-Binding Globulin/metabolism |
| مستخلص: | Objective: Recent research on sex hormone binding globulin (SHBG) has emphasized its role in the prediction of gestational diabetes mellitus (GDM) development. SHBG is associated with glucose tolerance status, and its level is regulated by prenatal and perinatal factors during pregnancy. This study aimed to determine the levels of SHBG in pregnant women with normal glucose tolerance and those with GDM in association with parity and gestational age (weeks). Materials and Methods: This cross-sectional study enrolled 218 pregnant women (165 controls and 53 women with GDM). Serum SHBG levels were analyzed using enzyme-linked immunosorbent assay. The association of SHBG with gestational age was assessed using multivariate regression analysis after adjustment for GDM-related risk factors. Results: Parity sub-group analyses indicated the presence of significant differences in the SHBG levels between nulliparous women in the GDM and control groups ( p = .04). Moreover, in the GDM group, SHBG was significantly associated with gestational age beyond the risk factors of GDM. Conclusion: This study demonstrated a strong association between SHBG and gestational age in women with GDM. Our findings suggest that parity and gestational age should be considered in the analysis of SHBG as a marker for GDM diagnosis. |
| فهرسة مساهمة: | Keywords: Gestational diabetes mellitus; gestational age (weeks); glucose tolerance status; parity; pregnancy; sex hormone binding globulin |
| المشرفين على المادة: | 0 (Sex Hormone-Binding Globulin) |
| تواريخ الأحداث: | Date Created: 20200425 Date Completed: 20220317 Latest Revision: 20220317 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/14767058.2020.1757059 |
| PMID: | 32326778 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2020.1757059 |