دورية أكاديمية
Higher Prevalence of Metabolic Syndrome in Child-adolescent Patients with Bipolar Disorder.
| العنوان: | Higher Prevalence of Metabolic Syndrome in Child-adolescent Patients with Bipolar Disorder. |
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| المؤلفون: | Mohite S; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA., Wu H; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA., Sharma S; The University of Texas Harris County Psychiatric Center, Houston, TX, USA., Lavagnino L; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA., Zeni CP; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA., Currie TT; The University of Texas Harris County Psychiatric Center, Houston, TX, USA., Soares JC; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA., Pigott TA; The University of Texas Harris County Psychiatric Center, Houston, TX, USA.; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA. |
| المصدر: | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology [Clin Psychopharmacol Neurosci] 2020 May 31; Vol. 18 (2), pp. 279-288. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean College of Neuropsychopharmacology Country of Publication: Korea (South) NLM ID: 101207332 Publication Model: Print Cited Medium: Print ISSN: 1738-1088 (Print) Linking ISSN: 17381088 NLM ISO Abbreviation: Clin Psychopharmacol Neurosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean College of Neuropsychopharmacology, c2003- |
| مستخلص: | Objective: Previous studies have indicated a convergent and bidirectional relationship between metabolic syndrome (MetS) and bipolar disorder (BD). As most of these studies focused mainly on adults diagnosed with BD, our study aims to investigate and characterize metabolic disturbances in child-adolescents diagnosed with BD. Methods: We retrospectively examined the medical records of psychiatric hospitalizations with admitting diagnosis of BD in child-adolescents (age ＜ 18 years). Body mass index (BMI), lipid profile, fasting blood glucose, and blood pressure were primary variables. National Cholesterol Education Program criteria were used to define MetS. Reference group data was obtained from the National Health and Nutrition Examination Survey study. Statistical analyses included t tests, chi-square tests, and Fisher's exact tests. Results: We identified 140 child-adolescent patients with BD (mean age = 15.12 ± 1.70 years, 53% male). MetS was significantly more common in BD compared to the reference group: 14% (95% confidence interval [95% CI] 8-20) vs. 6.7% (95% CI 4.1-9.2), p = 0.001 with no significant difference by sex. MetS components were higher in the BD group, particularly BMI ≥ 95% (25% vs. 11.8%, p ＜ 0.001) and high blood pressure (17% vs. 8%, p = 0.05). Moreover, female patients had lower odds of high blood pressure (odds ratio = 0.24 [95% CI 0.08-0.69], p = 0.005). Conclusion: Compared with the general child-adolescent population, the prevalence of MetS was significantly higher in patients with BD of same age. This reiterates the notion of an increased risk of MetS in patients diagnosed with BD; and thus, further exploration is warranted. |
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| فهرسة مساهمة: | Keywords: Bipolar disorder; Blood glucose; Body mass index; Child-adolescents; Lipids; Metabolic syndrome |
| تواريخ الأحداث: | Date Created: 20200425 Latest Revision: 20220414 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7242098 |
| DOI: | 10.9758/cpn.2020.18.2.279 |
| PMID: | 32329308 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1738-1088 |
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| DOI: | 10.9758/cpn.2020.18.2.279 |