دورية أكاديمية
أعرض في EDS

ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ.

التفاصيل البيبلوغرافية
العنوان: ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ.
المؤلفون: Kelly-Scumpia KM; Division of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: kkellyscumpia@mednet.ucla.edu., Choi A; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Shirazi R; Division of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Bersabe H; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Park E; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Scumpia PO; Division of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Ochoa MT; Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA., Yu J; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Ma F; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Pellegrini M; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA., Modlin RL; Division of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
المصدر: IScience [iScience] 2020 May 22; Vol. 23 (5), pp. 101050. Date of Electronic Publication: 2020 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Myeloid derived suppressor cells (MDSCs) are a population of immature myeloid cells that suppress adaptive immune function, yet the factors that regulate their suppressive function in patients with infection remain unclear. We studied MDSCs in patients with leprosy, a disease caused by Mycobacterium leprae, where clinical manifestations present on a spectrum that correlate with immunity to the pathogen. We found that HLA-DR - CD33 + CD15 + MDSCs were increased in blood from patients with disseminated/progressive lepromatous leprosy and possessed T cell-suppressive activity as compared with self-limiting tuberculoid leprosy. Mechanistically, we found ER stress played a critical role in regulating the T cell suppressive activity in these MDSCs. Furthermore, ER stress augmented IL-10 production, contributing to MDSC activity, whereas IFN-γ allowed T cells to overcome MDSC suppressive activity. These studies highlight a regulatory mechanism that links ER stress to IL-10 in mediating MDSC suppressive function in human infectious disease.
Competing Interests: Declaration of Interests The authors declare no competing interests.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: K01 AR070911 United States AR NIAMS NIH HHS; R01 AI022553 United States AI NIAID NIH HHS; R01 AR040312 United States AR NIAMS NIH HHS; R01 AR073252 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Biological Sciences; Cell Biology; Functional Aspects of Cell Biology; Immune Response; Immunology
تواريخ الأحداث: Date Created: 20200428 Latest Revision: 20210317
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7190750
DOI: 10.1016/j.isci.2020.101050
PMID: 32339990
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2020.101050