دورية أكاديمية
Honey bee virus causes context-dependent changes in host social behavior.
| العنوان: | Honey bee virus causes context-dependent changes in host social behavior. |
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| المؤلفون: | Geffre AC; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011., Gernat T; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Faculty of Mathematics and Computer Science, Department of Computer Science, University of Leipzig, 04109 Leipzig, Germany., Harwood GP; Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Jones BM; Program in Ecology, Evolution, and Conservation Biology, University of Illinois, Urbana-Champaign, IL 61801., Morselli Gysi D; Faculty of Mathematics and Computer Science, Department of Computer Science, University of Leipzig, 04109 Leipzig, Germany., Hamilton AR; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Bonning BC; Department of Entomology and Nematology, University of Florida, Gainesville, FL 32611., Toth AL; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011.; Department of Entomology, Iowa State University, Ames, IA 50011., Robinson GE; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Dolezal AG; Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; adolezal@illinois.edu. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 12; Vol. 117 (19), pp. 10406-10413. Date of Electronic Publication: 2020 Apr 27. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Bees/*virology , Dicistroviridae/*metabolism , Host-Pathogen Interactions/*physiology, Animals ; Beekeeping/methods ; Bees/genetics ; Behavior, Animal ; Colony Collapse/epidemiology ; DNA Viruses/genetics ; DNA Viruses/metabolism ; Dicistroviridae/genetics ; Dicistroviridae/pathogenicity ; Disease Transmission, Infectious/veterinary ; Mites/genetics ; Pollination ; RNA, Double-Stranded ; Social Behavior ; Virulence |
| مستخلص: | Anthropogenic changes create evolutionarily novel environments that present opportunities for emerging diseases, potentially changing the balance between host and pathogen. Honey bees provide essential pollination services, but intensification and globalization of honey bee management has coincided with increased pathogen pressure, primarily due to a parasitic mite/virus complex. Here, we investigated how honey bee individual and group phenotypes are altered by a virus of concern, Israeli acute paralysis virus (IAPV). Using automated and manual behavioral monitoring of IAPV-inoculated individuals, we find evidence for pathogen manipulation of worker behavior by IAPV, and reveal that this effect depends on social context; that is, within versus between colony interactions. Experimental inoculation reduced social contacts between honey bee colony members, suggesting an adaptive host social immune response to diminish transmission. Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees revealed these behaviors are part of a generalized social immune defensive response. Conversely, inoculated bees presented to groups of bees from other colonies experienced reduced aggression compared with dsRNA-immunostimulated bees, facilitating entry into susceptible colonies. This reduction was associated with a shift in cuticular hydrocarbons, the chemical signatures used by bees to discriminate colony members from intruders. These responses were specific to IAPV infection, suggestive of pathogen manipulation of the host. Emerging bee pathogens may thus shape host phenotypes to increase transmission, a strategy especially well-suited to the unnaturally high colony densities of modern apiculture. These findings demonstrate how anthropogenic changes could affect arms races between human-managed hosts and their pathogens to potentially affect global food security. Competing Interests: The authors declare no competing interest. |
| التعليقات: | Comment in: Nat Rev Microbiol. 2020 Jul;18(7):362-363. (PMID: 32404893) |
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| معلومات مُعتمدة: | R01 GM117467 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: honey bee; host–pathogen evolution; pathogen manipulation; virus |
| سلسلة جزيئية: | Dryad 10.5061/dryad.m63xsj3z8 |
| المشرفين على المادة: | 0 (RNA, Double-Stranded) |
| تواريخ الأحداث: | Date Created: 20200429 Date Completed: 20200821 Latest Revision: 20211204 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7229666 |
| DOI: | 10.1073/pnas.2002268117 |
| PMID: | 32341145 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.2002268117 |