دورية أكاديمية
MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life.
العنوان: | MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life. |
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المؤلفون: | Chorostecki U; Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain., Molina M; Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain., Pryszcz LP; Centre for Genomic Regulation, 08003 Barcelona, Spain.; International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland., Gabaldón T; Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.; ICREA, 08010 Barcelona, Spain. |
المصدر: | Nucleic acids research [Nucleic Acids Res] 2020 Jul 02; Vol. 48 (W1), pp. W553-W557. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd. |
مواضيع طبية MeSH: | Multigene Family* , Phylogeny* , Software*, Sequence Homology |
مستخلص: | Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some public databases include phylogenetic trees of homologous gene families which can be used to further differentiate homology relationships into orthology and paralogy. MetaPhOrs is a web server that integrates phylogenetic information from different sources to provide orthology and paralogy relationships based on a common phylogeny-based predictive algorithm and associated with a consistency-based confidence score. Here we describe the latest version of the web server which includes major new implementations and provides orthology and paralogy relationships derived from ∼8.2 million gene family trees-from 13 different source repositories across ∼4000 species with sequenced genomes. MetaPhOrs server is freely available, without registration, at http://orthology.phylomedb.org/. (© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
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تواريخ الأحداث: | Date Created: 20200429 Date Completed: 20201125 Latest Revision: 20201125 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7319458 |
DOI: | 10.1093/nar/gkaa282 |
PMID: | 32343307 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1362-4962 |
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DOI: | 10.1093/nar/gkaa282 |