دورية أكاديمية
The emergence of plasmid-borne cfr-mediated linezolid resistant-staphylococci in Vietnam.
| العنوان: | The emergence of plasmid-borne cfr-mediated linezolid resistant-staphylococci in Vietnam. |
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| المؤلفون: | Nguyen LTT; Biotechnology Center of Ho Chi Minh City, Viet Nam. Electronic address: lenacns2005@gmail.com., Nguyen KNT; University of Science, Vietnam National University HCMC, Viet Nam., Le PNTA; University of Medicine and Pharmacy, HCMC, Viet Nam., Cafini F; Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Madrid, Spain., Pascoe B; Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, Bath, UK., Sheppard SK; Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, Bath, UK., Nguyen TB; University of Medicine and Pharmacy, HCMC, Viet Nam., Nguyen TPH; Department of Genetics, Faculty of Biology and Biotechnology, University of Science, VNU-HCM, Viet Nam., Nguyen TV; Department of Genetics, Faculty of Biology and Biotechnology, University of Science, VNU-HCM, Viet Nam., Pham TTK; Biotechnology Center of Ho Chi Minh City, Viet Nam., Morikawa K; Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Japan. Electronic address: morikawa.kazuya.ga@u.tsukuba.ac.jp., Nguyen DQ; Biotechnology Center of Ho Chi Minh City, Viet Nam., Duong HX; Biotechnology Center of Ho Chi Minh City, Viet Nam. |
| المصدر: | Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2020 Sep; Vol. 22, pp. 462-465. Date of Electronic Publication: 2020 Apr 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer |
| مواضيع طبية MeSH: | Staphylococcal Infections* , Staphylococcus*/genetics, Bacterial Proteins/genetics ; China ; Humans ; Linezolid/pharmacology ; Microbial Sensitivity Tests ; Plasmids/genetics ; Thiamphenicol/analogs & derivatives ; Vietnam |
| مستخلص: | Objectives: Linezolid is one of the last resort antibiotics effectively used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria. Recent outbreaks of Linezolid resistance have been the great concern worldwide, while many countries have not experienced it. In this work, we aimed to evaluate the existence of linezolid resistance and further clarify potential resistance mechanism(s) in staphylococcal isolates obtained from the hospital in Vietnam, a country in which linezolid resistance had not been previously detected. Methods: Seventy staphylococcal clinical isolates including MRSA (n=63) and methicillin-resistant coagulase-negative staphylococci (MRCNS, n=7) were collected and analyzed for linezolid resistance. Linezolid-resistant isolates were submitted for whole genome sequencing to search for the resistance determinants. Results: We identified two coagulase-negative staphylococcal isolates that were resistant to linezolid. Whole genome sequencing revealed several alterations in the 23S rRNA and L3, L17, L22, L24, L30 ribosomal proteins. Importantly, both isolates harbour the chloramphenicol/florfenicol resistance (cfr) gene on a plasmid. The plasmid was closely identical to the pLRSA417 plasmid that was originally reported in China. Conclusions: To the best of our knowledge, this is the first report of cfr-mediated linezolid resistance in clinically isolated staphylococci in Vietnam. We suggest that adequate surveillance is necessary to monitor the dissemination of linezolid resistance among staphylococcal species and other important pathogens. (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Coagulase-negative staphylococci; Linezolid resistance; Vietnam; cfr |
| المشرفين على المادة: | 0 (Bacterial Proteins) 9J97307Y1H (florfenicol) FLQ7571NPM (Thiamphenicol) ISQ9I6J12J (Linezolid) |
| تواريخ الأحداث: | Date Created: 20200430 Date Completed: 20210623 Latest Revision: 20210623 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jgar.2020.04.008 |
| PMID: | 32348904 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2213-7173 |
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| DOI: | 10.1016/j.jgar.2020.04.008 |