دورية أكاديمية
Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats.
| العنوان: | Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats. |
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| المؤلفون: | Takemura A; Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 606-8501, Japan. takemura.ai.46c@kyoto-u.jp.; Department of Sports Research, Japan Institute of Sport Sciences, Tokyo, 115-0056, Japan. takemura.ai.46c@kyoto-u.jp., Pajevic PD; Department of Translational Dental Medicine, Boston University Goldman School of Dental Medicine, Boston, MA, 02118, USA., Egawa T; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 606-8501, Japan., Teshigawara R; Laboratory of Developmental Epigenome, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan., Hayashi T; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 606-8501, Japan., Ishihara A; Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 606-8501, Japan. |
| المصدر: | Journal of bone and mineral metabolism [J Bone Miner Metab] 2020 Sep; Vol. 38 (5), pp. 631-638. Date of Electronic Publication: 2020 Apr 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Society of Bone and Mineral Metabolism Country of Publication: Japan NLM ID: 9436705 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5604 (Electronic) Linking ISSN: 09148779 NLM ISO Abbreviation: J Bone Miner Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japanese Society of Bone and Mineral Metabolism, [1988- |
| مواضيع طبية MeSH: | Hyperbaric Oxygenation*, Hindlimb Suspension/*physiology , Osteoporosis/*physiopathology , Osteoporosis/*therapy, Animals ; Body Weight ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/metabolism ; Cancellous Bone/pathology ; Cancellous Bone/physiopathology ; Cortical Bone/pathology ; Cortical Bone/physiopathology ; Genetic Markers/genetics ; Growth Plate/pathology ; Male ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Osteoclasts/pathology ; Osteoporosis/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; RANK Ligand/genetics ; RANK Ligand/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar |
| مستخلص: | Introduction: Disuse-induced bone loss is caused by a suppression of osteoblastic bone formation and an increase in osteoclastic bone resorption. There are few data available for the effects of environmental conditions, i.e., atmospheric pressure and/or oxygen concentration, on osteoporosis. This study examined the effects of mild hyperbaric oxygen at 1317 hPa with 40% oxygen on unloading-induced osteoporosis. Materials and Methods: Eighteen 8-week old male Wistar rats were randomly divided into three groups: the control for 21 days without unloading and mild hyperbaric oxygen (NOR, n = 6), the unloading for 21 days and recovery for 10 days without mild hyperbaric oxygen (HU + NOR, n = 6), and the unloading for 21 days and recovery for 10 days with mild hyperbaric oxygen (HU + MHO, n = 6). Results: The cortical thickness and trabecular bone surface area were decreased in the HU + NOR group compared to the NOR group. There were no differences between the NOR and HU + MHO groups. Osteoclast surface area and Sclerostin (Sost) mRNA expression levels were decreased in the HU + MHO group compared to the HU + NOR group. These results suggested that the loss of the cortical and trabecular bone is inhibited by mild hyperbaric oxygen, because of an inhibition of osteoclasts and enhancement of bone formation with decreased Sost expression. Conclusions: We conclude that exposure to mild hyperbaric oxygen partially protects from the osteoporosis induced by hindlimb unloading. |
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| معلومات مُعتمدة: | 17J02040 Japan Society for the Promotion of Science |
| فهرسة مساهمة: | Keywords: Bone loss; Hindlimb unloading; Mild hyperbaric oxygen; Osteoporosis; Oxidative metabolism |
| المشرفين على المادة: | 0 (Bone Morphogenetic Proteins) 0 (Genetic Markers) 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) 0 (Ppargc1a protein, rat) 0 (RANK Ligand) 0 (RNA, Messenger) 0 (Sost protein, rat) 104982-03-8 (Osteocalcin) |
| تواريخ الأحداث: | Date Created: 20200501 Date Completed: 20200930 Latest Revision: 20220208 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s00774-020-01100-6 |
| PMID: | 32350615 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1435-5604 |
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| DOI: | 10.1007/s00774-020-01100-6 |