دورية أكاديمية
Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV.
| العنوان: | Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV. |
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| المؤلفون: | Ekrikpo UE; Department of Medicine, University of Uyo, Uyo, Nigeria; Kidney & Hypertension Research Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa., Mnika K; Division of Human Genetics, University of Cape Town, Cape Town, South Africa., Effa EE; Department of Medicine, University of Calabar, Calabar, Nigeria., Ajayi SO; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Okwuonu C; Department of Medicine, Federal Medical Centre, Umuahia, Nigeria., Waziri B; Department of Medicine, IBB Specialist Hospital, Minna, Nigeria., Bello A; Department of Medicine, University of Alberta, Edmonton, Canada., Dandara C; Division of Human Genetics, University of Cape Town, Cape Town, South Africa., Kengne AP; Non-communicable Disease Research Unit, Medical Research Council, Cape Town, South Africa., Wonkam A; Division of Human Genetics, University of Cape Town, Cape Town, South Africa. Electronic address: ambroise.wonkam@uct.ac.za., Okpechi I; Kidney & Hypertension Research Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: ikechi.okpechi@uct.ac.za. |
| المصدر: | American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2020 Jul; Vol. 76 (1), pp. 100-108. Date of Electronic Publication: 2020 Apr 27. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8110075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-6838 (Electronic) Linking ISSN: 02726386 NLM ISO Abbreviation: Am J Kidney Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : W.B. Saunders Original Publication: New York, N.Y. : Grune & Stratton, c1981- |
| مواضيع طبية MeSH: | Apolipoprotein L1/*genetics , HIV Infections/*genetics , Heme Oxygenase-1/*genetics , Polymorphism, Single Nucleotide/*genetics , Renal Insufficiency, Chronic/*genetics , Transforming Growth Factor beta1/*genetics, Adult ; Aged ; Female ; Genetic Association Studies ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Nigeria/epidemiology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology |
| مستخلص: | Rationale & Objective: Recent studies in the human immunodeficiency virus (HIV)-infected population have suggested that there are genetic predispositions to the development of chronic kidney disease (CKD) in this context. We investigated the association of genetic polymorphisms of the genes encoding apolipoprotein L1 (APOL1), transforming growth factor β1 (TGF-β1; a profibrotic cytokine), and heme oxygenase 1 (HMOX1) with prevalent CKD among adults with and without HIV infection. Study Design: Case-control study. Setting & Participants: West African adults including 217 HIV-infected patients with CKD (HIV + /CKD + group), 595 HIV-infected patients without CKD (HIV + /CKD - group), 269 with CKD and no HIV infection (HIV - /CKD + group), and 114 with neither CKD nor HIV (HIV - /CKD - group). Exposure: The genetic polymorphisms with reference single-nucleotide polymorphism (rs) identification numbers rs1800469 (TGF-β1), rs1800470 (TGF-β1), rs121918282 (TGF-β1); rs60910145 (APOL1 G1 risk allele), rs73885319 (APOL1 G1 risk allele), rs71785313 (APOL1 G2 risk allele), and rs743811 (HMOX1); HIV. Outcome: CKD. Analytical Approach: Single-nucleotide polymorphism (SNP) genotyping of rs1800469 (TGF-β1), rs1800470 (TGF-β1), rs121918282 (TGF-β1); rs60910145 (APOL1), rs73885319 (APOL1), rs71785313 (APOL1), and rs743811 (HMOX1) was performed. Hardy-Weinberg equilibrium was evaluated for all SNPs, and minor allele frequencies were reported. A case-control analysis was performed, and multivariable logistic regression was used to control for potential confounders. Results: Minor allele frequencies for TGF-β1 (rs1800469, rs1800470, and rs1800471), APOL1 (rs60910145, rs73885319, and rs71785313), and HMOX1 (rs743811) were 0.25, 0.46, 0.46, 0.44, 0.45, 0.17, and 0.14, respectively. Among HIV-positive individuals, only TGF-β1 rs1800470 (GG vs AA), APOL1 (in the recessive model), and hypertension were associated with prevalent CKD (adjusted ORs of 0.44 [95% CI, 0.20-0.97], 2.54 [95% CI, 1.44-4.51], and 2.17 [95% CI, 1.35-3.48], respectively). No SNP polymorphisms were associated with prevalent CKD among HIV-negative individuals. Limitations: The lack of histopathology data for proper categorization of the type of HIV-related nephropathy. Conclusions: APOL1 polymorphisms were highly prevalent in this population and among adult patients infected with HIV and were associated with increased CKD risk. The TGF-β1 (rs1800470) polymorphism was associated with reduced risk, and HMOX1 polymorphisms were unassociated with CKD. (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: APOL1; HIV; HMOX1; TGF-β1; West Africa; chronic kidney disease (CKD); genetic association; nonmodifiable risk factor; risk allele; single-nucleotide polymorphism (SNP) |
| المشرفين على المادة: | 0 (APOL1 protein, human) 0 (Apolipoprotein L1) 0 (TGFB1 protein, human) 0 (Transforming Growth Factor beta1) EC 1.14.14.18 (HMOX1 protein, human) EC 1.14.14.18 (Heme Oxygenase-1) |
| تواريخ الأحداث: | Date Created: 20200502 Date Completed: 20200929 Latest Revision: 20200929 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1053/j.ajkd.2020.01.006 |
| PMID: | 32354559 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1523-6838 |
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| DOI: | 10.1053/j.ajkd.2020.01.006 |