دورية أكاديمية
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study.
العنوان: | PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study. |
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المؤلفون: | Shrestha S; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Medical Scientist Training Program, University of Miami Miller School of Medicine, Miami, FL, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Kim MJ; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA. minjeong.kim@nih.gov.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA. minjeong.kim@nih.gov., Eldridge M; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Lehmann ML; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Frankland M; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Liow JS; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Yu ZX; National Heart, Lung, and Blood Institute Intramural Research Program, Bethesda, MD, USA., Cortes-Salva M; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Telu S; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Henter ID; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Gallagher E; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Lee JH; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Fredericks JM; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Poffenberger C; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Tye G; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Ruiz-Perdomo Y; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA., Anaya FJ; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Montero Santamaria JA; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Gladding RL; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Zoghbi SS; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Fujita M; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Katz JD; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA., Pike VW; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Innis RB; National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.; Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA. |
المصدر: | Journal of neuroinflammation [J Neuroinflammation] 2020 May 02; Vol. 17 (1), pp. 140. Date of Electronic Publication: 2020 May 02. |
نوع المنشور: | Clinical Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2004- |
مواضيع طبية MeSH: | Pyrimidines* , Radiopharmaceuticals*, Cyclooxygenase 2/*analysis , Inflammation/*diagnostic imaging , Positron-Emission Tomography/*methods, Adult ; Animals ; Arthritis, Rheumatoid/diagnostic imaging ; Brain/diagnostic imaging ; Female ; Humans ; Macaca mulatta ; Middle Aged |
مستخلص: | Background: Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing inflammatory response in the brain and periphery. To date, however, the development of PET radioligands for COX-2 has had limited success. Methods: The novel PET tracer [ 11 C]MC1 was used to examine COX-2 expression [1] in the brains of four rhesus macaques at baseline and after injection of the inflammogen lipopolysaccharide (LPS) into the right putamen, and [2] in the joints of two human participants with rheumatoid arthritis and two healthy individuals. In the primate study, two monkeys had one LPS injection, and two monkeys had a second injection 33 and 44 days, respectively, after the first LPS injection. As a comparator, COX-1 expression was measured using [ 11 C]PS13. Results: COX-2 binding, expressed as the ratio of specific to nondisplaceable uptake (BP Conclusions: Taken together, these results indicate that [ 11 C]MC1 can image and quantify COX-2 upregulation in both monkey brain after LPS-induced neuroinflammation and in human peripheral tissue with inflammation. Trial Registration: ClinicalTrials.gov NCT03912428. Registered April 11, 2019. |
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معلومات مُعتمدة: | T32 GM112601 United States GM NIGMS NIH HHS; ZIAMH002793 United States AR NIAMS NIH HHS; ZIAMH002795 United States MH NIMH NIH HHS |
فهرسة مساهمة: | Keywords: Cyclooxygenase 1; Cyclooxygenase 2; Inflammation; Lipopolysaccharide; Positron emission tomography; Rheumatoid arthritis |
سلسلة جزيئية: | ClinicalTrials.gov NCT03912428 |
المشرفين على المادة: | 0 ((11C)-MC1) 0 (Pyrimidines) 0 (Radiopharmaceuticals) EC 1.14.99.1 (Cyclooxygenase 2) |
تواريخ الأحداث: | Date Created: 20200504 Date Completed: 20210319 Latest Revision: 20210319 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7195739 |
DOI: | 10.1186/s12974-020-01804-6 |
PMID: | 32359360 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1742-2094 |
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DOI: | 10.1186/s12974-020-01804-6 |