دورية أكاديمية
Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids.
| العنوان: | Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids. |
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| المؤلفون: | Cunha AC; Departamento de Química Orgânica, Instituto de Química, Outeiro de São João Batista, Universidade Federal Fluminense, Niterói, RJ, 24020-141, Brazil., Ferreira VF; Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Dr. Mário Vianna 523, Niterói, RJ, 24241-002, Brazil., Vaz MGF; Departamento de Química Inorgânica, Instituto de Química, Outeiro de São João Batista, Universidade Federal Fluminense, Niterói, RJ, 24020-141, Brazil., Cassaro RAA; Departamento de Química Inorgânica, Instituto de Química, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, 21941-972, Brazil., Resende JALC; Laboratório de difração de Raios X, Programa de Pós-Graduação Em Química, Universidade Federal Fluminense, Niterói, RJ, 24020-141, Brazil.; Instituto de Ciências Exatas E da Terra, Universidade Federal do Mato Grosso, Barra do Garças, MT, 78698-000, Brazil., Sacramento CQ; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Costa J; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Abrantes JL; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Souza TML; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.; National Institute for Science and Technology On Innovation On Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil., Jordão AK; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, 59012-570, Brazil. akjordao@ccs.ufrn.br. |
| المصدر: | Molecular diversity [Mol Divers] 2021 Nov; Vol. 25 (4), pp. 2035-2043. Date of Electronic Publication: 2020 May 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers |
| أسماء مطبوعة: | Original Publication: Leiden, The Netherlands : ESCOM Science Publishers, c1995- |
| مواضيع طبية MeSH: | Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Herpesvirus 1, Human*/drug effects , Triazoles*/chemistry , Triazoles*/pharmacology , Nitrogen Oxides*/chemistry , Nitrogen Oxides*/pharmacology, Chlorocebus aethiops ; Vero Cells ; Animals ; Structure-Activity Relationship ; Acyclovir/pharmacology ; Acyclovir/chemistry ; Virus Replication/drug effects ; Cyclic N-Oxides/chemistry ; Cyclic N-Oxides/pharmacology |
| مستخلص: | HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clinical settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated. The nitroxide derivatives were characterized by infrared spectroscopy and elemental analysis, and three of them had their crystal structures determined by single-crystal X-ray diffraction. Four hybrid molecules showed important anti-HSV-1 activity with IC (© 2020. Springer Nature Switzerland AG.) |
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| فهرسة مساهمة: | Keywords: 1H-1,2,3-triazole derivatives; Anti-HSV-1 activity; Crystal structure; TEMPOL-based radicals |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Triazoles) GFQ4MMS07W (nitroxyl) 0 (Nitrogen Oxides) X4HES1O11F (Acyclovir) 0 (Cyclic N-Oxides) |
| تواريخ الأحداث: | Date Created: 20200508 Date Completed: 20240724 Latest Revision: 20240724 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1007/s11030-020-10094-2 |
| PMID: | 32377993 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-501X |
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| DOI: | 10.1007/s11030-020-10094-2 |