التفاصيل البيبلوغرافية
| العنوان: |
A role for neurogenesis in probabilistic reward learning. |
| المؤلفون: |
Seib DR; Department of Psychology., Espinueva DF; Department of Psychology., Floresco SB; Department of Psychology., Snyder JS; Department of Psychology. |
| المصدر: |
Behavioral neuroscience [Behav Neurosci] 2020 Aug; Vol. 134 (4), pp. 283-295. Date of Electronic Publication: 2020 May 07. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Psychological Association Country of Publication: United States NLM ID: 8302411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-0084 (Electronic) Linking ISSN: 07357044 NLM ISO Abbreviation: Behav Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, D.C. : American Psychological Association, [c1983- |
| مواضيع طبية MeSH: |
Learning/*physiology , Neurogenesis/*physiology, Animals ; Conditioning, Operant/physiology ; Corpus Striatum/physiology ; Hippocampus/metabolism ; Hippocampus/physiology ; Male ; Memory/physiology ; Neurons/physiology ; Probability Learning ; Rats ; Rats, Long-Evans ; Rats, Transgenic ; Reversal Learning/physiology ; Reward ; Uncertainty |
| مستخلص: |
Rewards are often unreliable and optimal choice requires behavioral flexibility and learning about the probabilistic nature of uncertain rewards. Probabilistic learning occurs over multiple trials, often without conscious knowledge, and is traditionally associated with striatal function. While the hippocampus is classically recognized for its role in memory for individual experiences, recent work indicates that it is also involved in probabilistic forms of learning but little is known about the features that support such learning. We hypothesized that adult neurogenesis may be involved, because adult-born neurons contribute to both learning and reward-related behaviors. To test this, we used an appetitive probabilistic reversal learning task where a correct lever is rewarded with 80% probability and an incorrect lever is rewarded with 20% probability. Behavioral flexibility was assessed by switching correct-incorrect lever identities after 8 consecutive correct choices. Transgenic male rats that lacked adult neurogenesis displayed an initial deficit in discriminating the correct and incorrect levers, but they were not impaired at reversing behavior when the reward contingencies switched. When reward was withheld after a correct lever choice, neurogenesis-deficient rats were more likely to choose the incorrect lever on the subsequent trial. Also, rats with intact neurogenesis were more sensitive to reward at the incorrect lever. Differences were not observed in control transgenic rats that had intact neurogenesis. These results identify a novel role for neurogenesis in learning about uncertain, probabilistic rewards. Altered sensitivity to reward and negative feedback furthermore implicates neurogenesis in cognitive phenotypes associated with mood disorders such as depression. (PsycInfo Database Record (c) 2020 APA, all rights reserved). |
| معلومات مُعتمدة: |
Canada CAPMC CIHR; Michael Smith Foundation for Health Research; Brain and Behavior Research Foundation; German Research Foundation; Canada CAPMC CIHR |
| تواريخ الأحداث: |
Date Created: 20200508 Date Completed: 20210419 Latest Revision: 20210419 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1037/bne0000370 |
| PMID: |
32378907 |
| قاعدة البيانات: |
MEDLINE |
