دورية أكاديمية
أعرض في EDS

Natural History of Non-Alcoholic Fatty Liver Disease: A Study With Paired Liver Biopsies.

التفاصيل البيبلوغرافية
العنوان: Natural History of Non-Alcoholic Fatty Liver Disease: A Study With Paired Liver Biopsies.
المؤلفون: Reddy YK; Division of Transplant Surgery, Department of Surgery, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, Memphis, TN, 38104, USA., Marella HK; Division of Transplant Surgery, Department of Surgery, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, Memphis, TN, 38104, USA., Jiang Y; Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, TN, 38152, USA., Ganguli S; Department of Medicine, University of Louisville, Louisville, KY, 40202, USA., Snell P; Division of Transplant Surgery, Department of Surgery, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, Memphis, TN, 38104, USA., Podila PSB; Methodist University Hospital, Methodist Le Bonheur Healthcare, Memphis, TN, USA., Maliakkal B; Division of Transplant Surgery, Department of Surgery, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, Memphis, TN, 38104, USA., Satapathy SK; Division of Hepatology and Sandra Atlas Bass Center for Liver Diseases, Donald and Barbara Zucker School of Medicine/Northwell Health, Manhasset, NY, 11030, USA.
المصدر: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2020 May-Jun; Vol. 10 (3), pp. 245-254. Date of Electronic Publication: 2019 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: India NLM ID: 101574137 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0973-6883 (Print) Linking ISSN: 09736883 NLM ISO Abbreviation: J Clin Exp Hepatol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Gurgaon, India : Elsevier, 2011-
مستخلص: Background: Although there is unequivocal evidence for progression of nonalcoholic steatohepatitis (NASH) to cirrhosis, there is uncertainty with regard to the progression to nonalcoholic fatty liver (NAFL) and NASH.
Aims: We investigated the rate of progression to NASH and advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and assessed the factors associated with such progression.
Methods: Histological assessment was performed in 36 patients with NAFLD with paired liver biopsies (≥1 year apart; median, 3.8 years; range, 1-10.33 years). NASH Clinical Research Network (NASH CRN) criteria were used to assess NAFLD Activity Score (NAS).
Results: At baseline, 26 (72%) patients had NAFL and 10 (28%) patients had NASH. At follow-up, 27% NAFL progressed to NASH (NAS score ≥5), and 50% of patients with NASH no longer met the criteria of NASH. Fibrosis progressed in 15 (42%), regressed in 9 (25%), and remained stable in 12 (33%) patients overall. Thirty-five percent of patients with NAFL had fibrosis progression. The incidence of type 2 diabetes mellitus (T2DM) was higher in patients with NASH versus NAFL (40% vs. 27%). Both at the time of baseline and follow-up, liver biopsies, composite models of noninvasive scores such as Fibrosis-4 (FIB-4) score and NAFLD fibrosis score, and ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) were all significantly higher in progressors than in nonprogressors.
Conclusions: NAFLD is a dynamic liver disease with varying degrees of progression and regression. T2DM was strongly associated with fibrosis progression. Noninvasive fibrosis scores such as AST/ALT ratio, FIB-4 score, and NAFLD fibrosis score can identify those at risk of fibrosis progression.
(© 2019 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: ALT, alanine aminotransferase; AST, aspartate aminotransferase; FIB-4 score, Fibrosis-4 score; NAFL, Nonalcoholic fatty liver; NAFLD, Nonalcoholic fatty liver disease; NAS, NAFLD Activity Score; NASH CRN, NASH Clinical Research Network; NASH, Nonalcoholic steatohepatitis; T2DM, Type 2 diabetes mellitus; metabolic syndrome; natural history; nonalcoholic fatty liver; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity-related liver disease
تواريخ الأحداث: Date Created: 20200515 Latest Revision: 20220414
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7212293
DOI: 10.1016/j.jceh.2019.07.002
PMID: 32405181
قاعدة البيانات: MEDLINE
الوصف
تدمد:0973-6883
DOI:10.1016/j.jceh.2019.07.002