دورية أكاديمية
Multiplexed polarized hypodermic Raman needle probe for biostructural analysis of articular cartilage.
| العنوان: | Multiplexed polarized hypodermic Raman needle probe for biostructural analysis of articular cartilage. |
|---|---|
| المؤلفون: | Jensen M, Horgan CC, Vercauteren T, Albro MB, Bergholt MS |
| المصدر: | Optics letters [Opt Lett] 2020 May 15; Vol. 45 (10), pp. 2890-2893. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 7708433 Publication Model: Print Cited Medium: Internet ISSN: 1539-4794 (Electronic) Linking ISSN: 01469592 NLM ISO Abbreviation: Opt Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: New York, Optical Society of America. |
| مواضيع طبية MeSH: | Needles*, Cartilage, Articular/*metabolism , Spectrum Analysis, Raman/*instrumentation, Collagen/metabolism |
| مستخلص: | In this Letter, we report a multiplexed polarized hypodermic Raman needle probe for the biostructural analysis of articular cartilage. Using a custom-developed needle probe with a sapphire ball lens, we measure polarized Raman spectra of cartilage. By imaging two polarizations simultaneously on the charge-coupled device (CCD) and binning them separately, we capture both biochemical and structural tissue information in real time. Here, we demonstrate that polarized Raman spectroscopy can distinguish between different collagen fibril alignment orientations in a cartilage explant model system, supporting its capacity for diagnosing the hallmark collagen alignment changes occurring in the early stages of osteoarthritis (OA). Accordingly, this work shows that needle-based polarized Raman spectroscopy has great potential for the monitoring and diagnosis of early OA. |
| المشرفين على المادة: | 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20200516 Date Completed: 20210301 Latest Revision: 20210301 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1364/OL.390998 |
| PMID: | 32412494 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1539-4794 |
|---|---|
| DOI: | 10.1364/OL.390998 |