دورية أكاديمية
Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions.
| العنوان: | Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions. |
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| المؤلفون: | Cucinotta FA; Department of Health Physics and Diagnostic Sciences, University of Nevada, Box 453037, Las Vegas, NV 89195-3037, United States. Electronic address: francis.cucinotta@unlv.edu., Cacao E; Department of Health Physics and Diagnostic Sciences, University of Nevada, Box 453037, Las Vegas, NV 89195-3037, United States. |
| المصدر: | Life sciences in space research [Life Sci Space Res (Amst)] 2020 May; Vol. 25, pp. 129-135. Date of Electronic Publication: 2019 Oct 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101632373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-5532 (Electronic) Linking ISSN: 22145524 NLM ISO Abbreviation: Life Sci Space Res (Amst) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Ltd, [2014]- |
| مواضيع طبية MeSH: | Space Flight*, Cognition/*radiation effects , Cosmic Radiation/*adverse effects, Animals ; Astronauts ; Humans ; Memory/radiation effects ; Models, Theoretical ; Pattern Recognition, Visual/radiation effects ; Radiation Dosage ; Radiation Protection ; Risk Assessment ; Rodentia |
| مستخلص: | For the first-time we report on predictions on cognitive detriments from galactic cosmic ray (GCR) exposures on long-duration space missions outside the protection of the Earth's magnetosphere and solid body shielding. Estimates are based on a relative risk (RR) model of the fluence response for proton and heavy ion in rodent studies using the widely used novel object recognition (NOR) test, which estimates detriments in recognition or object memory. Our recent meta-analysis showed that linear and linear-quadratic dose response models were not accurate, while exponential increasing fluence response models based on particle track structure provided good descriptions of rodent data for doses up to 1 Gy. Using detailed models of the GCR environment and particle transport in shielding and tissue, we predict the excess relative risk (ERR) for NOR detriments for several long-term space mission scenarios. Predictions suggest ERR < 0.15 for most space mission scenarios with ERR<0.1 for 1-year lunar surface missions, and about ERR~0.1 for a 1000 day Mars mission for average solar cycle conditions. We discuss possible implications of these ERR levels of cognitive performance detriments relative to other neurological challenges such as rodent models of Alzheimer's disease (AD), Parkinson's disease (PD) and traumatic brain injury (TBI). Comparisons suggest a small but potentially clinically significant risk for possible space mission scenarios. Competing Interests: Declaration of Competing Interest The 'author's declare no conflicts of interest. (Copyright © 2019 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cognitive detriments; Galactic cosmic rays; Novel object recognition; Space radiation; Track structure models; Voyager I measurements |
| تواريخ الأحداث: | Date Created: 20200517 Date Completed: 20210119 Latest Revision: 20210119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.lssr.2019.10.004 |
| PMID: | 32414486 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2214-5532 |
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| DOI: | 10.1016/j.lssr.2019.10.004 |