دورية أكاديمية
أعرض في EDS

Translation at first sight: the influence of leading codons.

التفاصيل البيبلوغرافية
العنوان: Translation at first sight: the influence of leading codons.
المؤلفون: Osterman IA; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia., Chervontseva ZS; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; A.A.Kharkevich Institute for Information Transmission Problems, Moscow 127051, Russia., Evfratov SA; Lomonosov Moscow State University, Moscow 119992, Russia., Sorokina AV; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia., Rodin VA; Lomonosov Moscow State University, Moscow 119992, Russia., Rubtsova MP; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia., Komarova ES; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia., Zatsepin TS; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia., Kabilov MR; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia., Bogdanov AA; Lomonosov Moscow State University, Moscow 119992, Russia., Gelfand MS; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; A.A.Kharkevich Institute for Information Transmission Problems, Moscow 127051, Russia., Dontsova OA; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region 143025, Russia.; Lomonosov Moscow State University, Moscow 119992, Russia.
المصدر: Nucleic acids research [Nucleic Acids Res] 2020 Jul 09; Vol. 48 (12), pp. 6931-6942.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Nucleic Acid Conformation* , Protein Biosynthesis*, Codon, Initiator/*genetics , RNA, Messenger/*genetics, Codon, Initiator/ultrastructure ; Escherichia coli/genetics ; Green Fluorescent Proteins/genetics ; Peptide Chain Initiation, Translational ; RNA, Messenger/ultrastructure ; Ribosomes/genetics ; Ribosomes/ultrastructure
مستخلص: First triplets of mRNA coding region affect the yield of translation. We have applied the flowseq method to analyze >30 000 variants of the codons 2-11 of the fluorescent protein reporter to identify factors affecting the protein synthesis. While the negative influence of mRNA secondary structure on translation has been confirmed, a positive role of rare codons at the beginning of a coding sequence for gene expression has not been observed. The identity of triplets proximal to the start codon contributes more to the protein yield then more distant ones. Additional in-frame start codons enhance translation, while Shine-Dalgarno-like motifs downstream the initiation codon are inhibitory. The metabolic cost of amino acids affects the yield of protein in the poor medium. The most efficient translation was observed for variants with features resembling those of native Escherichia coli genes.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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المشرفين على المادة: 0 (Codon, Initiator)
0 (RNA, Messenger)
147336-22-9 (Green Fluorescent Proteins)
تواريخ الأحداث: Date Created: 20200520 Date Completed: 20200908 Latest Revision: 20200908
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7337518
DOI: 10.1093/nar/gkaa430
PMID: 32427319
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkaa430