دورية أكاديمية
أعرض في EDS

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.

التفاصيل البيبلوغرافية
العنوان: Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.
المؤلفون: Maitra N; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States., He C; Buck Institute for Research on Aging, Novato, United States., Blank HM; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States., Tsuchiya M; Department of Pathology, University of Washington, Seattle, United States., Schilling B; Buck Institute for Research on Aging, Novato, United States., Kaeberlein M; Department of Pathology, University of Washington, Seattle, United States., Aramayo R; Department of Biology, Texas A&M University, College Station, United States., Kennedy BK; Buck Institute for Research on Aging, Novato, United States.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Healthy Ageing, National University of Singapore, National University Health System, Singapore, Singapore., Polymenis M; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
المصدر: ELife [Elife] 2020 May 20; Vol. 9. Date of Electronic Publication: 2020 May 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Gene Expression Regulation* , Protein Biosynthesis*, Carbon/*metabolism , Cell Division/*physiology , Cellular Senescence/*physiology , RNA-Binding Proteins/*physiology , Ribosomal Proteins/*physiology , Saccharomyces cerevisiae Proteins/*physiology, Cell Cycle/genetics ; Cell Division/genetics ; Cellular Senescence/genetics ; Gene Library ; Loss of Function Mutation ; Methionine/metabolism ; Phenotype ; RNA, Fungal ; RNA-Binding Proteins/genetics ; RNA-Seq ; Ribosomal Proteins/genetics ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Serine/metabolism
مستخلص: A long-standing problem is how cells that lack one of the highly similar ribosomal proteins (RPs) often display distinct phenotypes. Yeast and other organisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit of the ribosome. However, longevity is neither associated with the generation time of RP deletion mutants nor with bulk inhibition of protein synthesis. Here, we queried actively dividing RP mutants through the cell cycle. Our data link transcriptional, translational, and metabolic changes to phenotypes associated with the loss of paralogous RPs. We uncovered translational control of transcripts encoding enzymes of methionine and serine metabolism, which are part of one-carbon (1C) pathways. Cells lacking Rpl22Ap, which are long-lived, have lower levels of metabolites associated with 1C metabolism. Loss of 1C enzymes increased the longevity of wild type cells. 1C pathways exist in all organisms and targeting the relevant enzymes could represent longevity interventions.
Competing Interests: NM, CH, HB, MT, BS, RA, BK, MP No competing interests declared, MK Reviewing editor, eLife
(© 2020, Maitra et al.)
References: F1000Res. 2014 Apr 24;3:95. (PMID: 24860646)
Cell Metab. 2015 Nov 3;22(5):895-906. (PMID: 26456335)
Aging (Albany NY). 2012 Dec;4(12):894-8. (PMID: 23525940)
J Biol Chem. 2002 Oct 11;277(41):38381-9. (PMID: 12161434)
Nature. 2002 Jul 25;418(6896):387-91. (PMID: 12140549)
Microb Cell. 2015 Mar 20;2(4):94-104. (PMID: 28357283)
Proc Natl Acad Sci U S A. 1981 May;78(5):3030-3. (PMID: 7019917)
Science. 2017 Nov 3;358(6363):. (PMID: 29097519)
Cell. 2007 Nov 2;131(3):557-71. (PMID: 17981122)
Science. 2005 Nov 18;310(5751):1193-6. (PMID: 16293764)
Mol Cell. 2017 Jul 6;67(1):3-4. (PMID: 28686875)
CSH Protoc. 2006 Jun 01;2006(1):. (PMID: 22485553)
Hum Mutat. 2014 Dec;35(12):1442-5. (PMID: 25196364)
Front Cell Dev Biol. 2018 Aug 15;6:90. (PMID: 30159313)
Wiley Interdiscip Rev Syst Biol Med. 2018 Nov;10(6):e1426. (PMID: 29889360)
Nat Biotechnol. 2013 Jan;31(1):46-53. (PMID: 23222703)
Genome Biol. 2009;10(3):R25. (PMID: 19261174)
G3 (Bethesda). 2013 Sep 04;3(9):1525-30. (PMID: 23821617)
Trends Cell Biol. 2017 Sep;27(9):645-657. (PMID: 28601431)
CSH Protoc. 2006 Jun 01;2006(1):. (PMID: 22485564)
Vitam Horm. 2008;79:1-44. (PMID: 18804690)
Bioinformatics. 2013 Dec 1;29(23):2995-3002. (PMID: 24048356)
Immunity. 2007 Jun;26(6):759-72. (PMID: 17555992)
Elife. 2018 Aug 17;7:. (PMID: 30117416)
Nat Protoc. 2012 Jul 26;7(8):1534-50. (PMID: 22836135)
Med Princ Pract. 2005;14 Suppl 1:2-14. (PMID: 16103708)
Elife. 2017 Aug 31;6:. (PMID: 28857745)
PLoS Genet. 2012;8(3):e1002590. (PMID: 22438835)
J Biol Chem. 2000 Oct 6;275(40):30987-95. (PMID: 10871621)
Mol Cell Biol. 1985 Sep;5(9):2349-60. (PMID: 3915540)
J Mol Biol. 1973 Feb 5;73(4):513-25. (PMID: 4577041)
FEMS Yeast Res. 2014 May;14(3):425-34. (PMID: 24410772)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Metabolites. 2019 Mar 22;9(3):. (PMID: 30909447)
Lab Chip. 2013 Nov 7;13(21):4217-24. (PMID: 23986263)
Elife. 2015 Dec 01;4:e08527. (PMID: 26422514)
Methods Mol Biol. 2017;1550:223-233. (PMID: 28188533)
Sci Rep. 2018 Jan 17;8(1):1010. (PMID: 29343716)
Bioinformatics. 2017 Jun 1;33(11):1735-1737. (PMID: 28158331)
J Biol Chem. 2012 Feb 10;287(7):4790-9. (PMID: 22194612)
PLoS Genet. 2014 May 01;10(5):e1004347. (PMID: 24785424)
Nat Genet. 2006 Sep;38(9):993-8. (PMID: 16941010)
Genetics. 2012 May;191(1):107-18. (PMID: 22377630)
Science. 1967 Feb 24;155(3765):1026-7. (PMID: 17830494)
J Immunol. 2011 Jul 15;187(2):664-75. (PMID: 21690328)
Arch Microbiol. 2004 Oct;182(4):326-30. (PMID: 15349714)
Genetics. 2018 Nov;210(3):895-906. (PMID: 30150288)
Cell Rep. 2016 Jan 5;14(1):22-31. (PMID: 26725116)
Methods. 2017 Aug 15;126:112-129. (PMID: 28579404)
Mol Biol Evol. 2012 Jan;29(1):81-9. (PMID: 21965341)
Mol Syst Biol. 2006;2:2006.0001. (PMID: 16738548)
FEMS Yeast Res. 2007 Mar;7(2):244-53. (PMID: 16989656)
Curr Genet. 2017 Dec;63(6):959-964. (PMID: 28451847)
Science. 2009 Apr 10;324(5924):218-23. (PMID: 19213877)
Aging (Albany NY). 2019 May 9;11(9):2874-2888. (PMID: 31076561)
J Mol Biol. 2016 May 22;428(10 Pt B):2186-94. (PMID: 26764228)
Mol Biol Cell. 2020 May 1;31(10):1069-1084. (PMID: 32129706)
Cell. 2008 Apr 18;133(2):292-302. (PMID: 18423200)
Cell Syst. 2018 Feb 28;6(2):192-205.e3. (PMID: 29361465)
Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5505-10. (PMID: 20212107)
Blood. 2012 Nov 1;120(18):3764-73. (PMID: 22976955)
Microb Cell. 2014 Aug 01;1(8):256-266. (PMID: 28357252)
Nat Commun. 2012 Jul 03;3:937. (PMID: 22760636)
Cell Rep. 2017 Jan 10;18(2):545-556. (PMID: 28076796)
Blood. 2015 Feb 26;125(9):1377-82. (PMID: 25575543)
Cell Rep. 2016 Feb 23;14(7):1787-1799. (PMID: 26876183)
Nat Rev Cancer. 2019 Apr;19(4):228-238. (PMID: 30670820)
BMC Bioinformatics. 2011 Aug 04;12:323. (PMID: 21816040)
Med Res Rev. 2015 Mar;35(2):225-85. (PMID: 25164622)
Genes Dev. 1997 Oct 1;11(19):2522-31. (PMID: 9334317)
Nat Rev Cancer. 2013 Aug;13(8):572-83. (PMID: 23822983)
PLoS One. 2014 May 15;9(5):e97729. (PMID: 24830393)
Mol Cell. 2009 Apr 10;34(1):3-11. (PMID: 19362532)
Bioinformatics. 2011 Nov 1;27(21):2987-93. (PMID: 21903627)
Mol Biol Cell. 2013 Dec;24(23):3620-33. (PMID: 24109599)
PLoS Genet. 2014 Dec 18;10(12):e1004860. (PMID: 25521617)
Aging Cell. 2011 Apr;10(2):185-90. (PMID: 21176090)
Gynecol Oncol. 2013 Mar;128(3):470-4. (PMID: 23127973)
Int J Oncol. 2016 Apr;48(4):1313-24. (PMID: 26892688)
Nat Biotechnol. 2011 Jan;29(1):24-6. (PMID: 21221095)
PLoS Genet. 2013;9(8):e1003708. (PMID: 23990801)
Molecules. 2016 May 30;21(6):. (PMID: 27248987)
N Engl J Med. 1948 Jun 3;238(23):787-93. (PMID: 18860765)
Mol Cell Biol. 1988 Nov;8(11):4675-84. (PMID: 3062366)
G3 (Bethesda). 2019 Jan 9;9(1):239-250. (PMID: 30463882)
EMBO J. 2017 Feb 15;36(4):487-502. (PMID: 28057705)
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426. (PMID: 30407594)
Nucleic Acids Res. 2019 Jan 8;47(D1):D330-D338. (PMID: 30395331)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
Cell Metab. 2017 Jan 10;25(1):27-42. (PMID: 27641100)
J Bacteriol. 1979 Feb;137(2):1048-50. (PMID: 370092)
Nat Rev Mol Cell Biol. 2012 May 23;13(6):355-69. (PMID: 22617470)
Anal Biochem. 1984 Jan;136(1):65-74. (PMID: 6711815)
Nature. 1974 Oct 4;251(5474):385-8. (PMID: 4421673)
Mol Cell. 2017 Jul 6;67(1):71-83.e7. (PMID: 28625553)
J Biol Chem. 2003 Mar 21;278(12):10264-72. (PMID: 12525494)
Bioinformatics. 2011 Apr 15;27(8):1157-8. (PMID: 21320865)
Cell. 2018 Mar 22;173(1):90-103.e19. (PMID: 29551269)
J Biol Chem. 2000 Jul 7;275(27):20920-7. (PMID: 10877846)
Brief Bioinform. 2013 Mar;14(2):178-92. (PMID: 22517427)
J Biol Chem. 2003 Jun 27;278(26):23553-60. (PMID: 12700234)
Mol Cell. 2019 Jan 3;73(1):36-47.e10. (PMID: 30503772)
Nat Commun. 2014 Apr 07;5:3592. (PMID: 24710037)
J Vis Exp. 2009 Jun 25;(28):. (PMID: 19556967)
معلومات مُعتمدة: P01 AG001751 United States AG NIA NIH HHS; S10 OD028654 United States OD NIH HHS; P30 AG013280 United States AG NIA NIH HHS; 1S10 OD016281 United States RR NCRR NIH HHS; R01 GM123139 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Rpl22; S. cerevisiae; cell cycle; chromosomes; gene expression; genetics; genomics; longevity; one-carbon; ribosomal; translation
سلسلة جزيئية: GEO GSE135336
المشرفين على المادة: 0 (RNA, Fungal)
0 (RNA-Binding Proteins)
0 (Ribosomal Proteins)
0 (Rpl22 protein, S cerevisiae)
0 (Saccharomyces cerevisiae Proteins)
452VLY9402 (Serine)
7440-44-0 (Carbon)
AE28F7PNPL (Methionine)
تواريخ الأحداث: Date Created: 20200521 Date Completed: 20210303 Latest Revision: 20210319
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7263821
DOI: 10.7554/eLife.53127
PMID: 32432546
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.53127