دورية أكاديمية
Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.
العنوان: | Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity. |
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المؤلفون: | Maitra N; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States., He C; Buck Institute for Research on Aging, Novato, United States., Blank HM; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States., Tsuchiya M; Department of Pathology, University of Washington, Seattle, United States., Schilling B; Buck Institute for Research on Aging, Novato, United States., Kaeberlein M; Department of Pathology, University of Washington, Seattle, United States., Aramayo R; Department of Biology, Texas A&M University, College Station, United States., Kennedy BK; Buck Institute for Research on Aging, Novato, United States.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Healthy Ageing, National University of Singapore, National University Health System, Singapore, Singapore., Polymenis M; Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States. |
المصدر: | ELife [Elife] 2020 May 20; Vol. 9. Date of Electronic Publication: 2020 May 20. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Gene Expression Regulation* , Protein Biosynthesis*, Carbon/*metabolism , Cell Division/*physiology , Cellular Senescence/*physiology , RNA-Binding Proteins/*physiology , Ribosomal Proteins/*physiology , Saccharomyces cerevisiae Proteins/*physiology, Cell Cycle/genetics ; Cell Division/genetics ; Cellular Senescence/genetics ; Gene Library ; Loss of Function Mutation ; Methionine/metabolism ; Phenotype ; RNA, Fungal ; RNA-Binding Proteins/genetics ; RNA-Seq ; Ribosomal Proteins/genetics ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Serine/metabolism |
مستخلص: | A long-standing problem is how cells that lack one of the highly similar ribosomal proteins (RPs) often display distinct phenotypes. Yeast and other organisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit of the ribosome. However, longevity is neither associated with the generation time of RP deletion mutants nor with bulk inhibition of protein synthesis. Here, we queried actively dividing RP mutants through the cell cycle. Our data link transcriptional, translational, and metabolic changes to phenotypes associated with the loss of paralogous RPs. We uncovered translational control of transcripts encoding enzymes of methionine and serine metabolism, which are part of one-carbon (1C) pathways. Cells lacking Rpl22Ap, which are long-lived, have lower levels of metabolites associated with 1C metabolism. Loss of 1C enzymes increased the longevity of wild type cells. 1C pathways exist in all organisms and targeting the relevant enzymes could represent longevity interventions. Competing Interests: NM, CH, HB, MT, BS, RA, BK, MP No competing interests declared, MK Reviewing editor, eLife (© 2020, Maitra et al.) |
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معلومات مُعتمدة: | P01 AG001751 United States AG NIA NIH HHS; S10 OD028654 United States OD NIH HHS; P30 AG013280 United States AG NIA NIH HHS; 1S10 OD016281 United States RR NCRR NIH HHS; R01 GM123139 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: Rpl22; S. cerevisiae; cell cycle; chromosomes; gene expression; genetics; genomics; longevity; one-carbon; ribosomal; translation |
سلسلة جزيئية: | GEO GSE135336 |
المشرفين على المادة: | 0 (RNA, Fungal) 0 (RNA-Binding Proteins) 0 (Ribosomal Proteins) 0 (Rpl22 protein, S cerevisiae) 0 (Saccharomyces cerevisiae Proteins) 452VLY9402 (Serine) 7440-44-0 (Carbon) AE28F7PNPL (Methionine) |
تواريخ الأحداث: | Date Created: 20200521 Date Completed: 20210303 Latest Revision: 20210319 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7263821 |
DOI: | 10.7554/eLife.53127 |
PMID: | 32432546 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.53127 |