دورية أكاديمية
أعرض في EDS

Ebola-Specific CD8+ and CD4+ T-Cell Responses in Sierra Leonean Ebola Virus Survivors With or Without Post-Ebola Sequelae.

التفاصيل البيبلوغرافية
العنوان: Ebola-Specific CD8+ and CD4+ T-Cell Responses in Sierra Leonean Ebola Virus Survivors With or Without Post-Ebola Sequelae.
المؤلفون: LaVergne SM; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA.; Division of Infectious Diseases, University of California, San Diego, La Jolla, California, USA., Sakabe S; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA., Kanneh L; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Momoh M; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone.; Eastern Polytechnic Institute, Kenema, Sierra Leone., Al-Hassan F; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Yilah M; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Goba A; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Sandi JD; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Gbakie M; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Cubitt B; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA., Boisen M; Zalgen Labs, Germantown, USA., Mayeux JM; Department of Molecular Medicine, Scripps Research, La Jolla, California, USA., Smira A; Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA., Shore K; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Bica I; Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA., Pollard KM; Department of Molecular Medicine, Scripps Research, La Jolla, California, USA., Carlos de la Torre J; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA., Branco LM; Zalgen Labs, Germantown, USA., Garry RF; Department of Immunology and Microbiology, Tulane University School of Medicine, New Orleans, Louisiana, USA., Grant DS; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone.; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Schieffelin JS; Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA., Oldstone MBA; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA., Sullivan BM; Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA.
المصدر: The Journal of infectious diseases [J Infect Dis] 2020 Oct 01; Vol. 222 (9), pp. 1488-1497.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*immunology , CD8-Positive T-Lymphocytes/*immunology , Ebolavirus/*immunology , Hemorrhagic Fever, Ebola/*immunology, Adult ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; Female ; Fluorescent Antibody Technique ; Hemorrhagic Fever, Ebola/pathology ; Humans ; Immunity, Cellular ; Male ; Sierra Leone/epidemiology ; Survivors
مستخلص: Background: Ebola virus (EBOV) disease has killed thousands of West and Central Africans over the past several decades. Many who survive the acute disease later experience post-Ebola syndrome, a constellation of symptoms whose causative pathogenesis is unclear.
Methods: We investigated EBOV-specific CD8+ and CD4+ T-cell responses in 37 Sierra Leonean EBOV disease survivors with (n = 19) or without (n = 18) sequelae of arthralgia and ocular symptoms. Peripheral blood mononuclear cells were infected with recombinant vesicular stomatitis virus encoding EBOV antigens. We also studied the presence of EBOV-specific immunoglobulin G, antinuclear antibodies, anti-cyclic citrullinated peptide antibodies, rheumatoid factor, complement levels, and cytokine levels in these 2 groups.
Results: Survivors with sequelae had a significantly higher EBOV-specific CD8+ and CD4+ T-cell response. No differences in EBOV-specific immunoglobulin G, antinuclear antibody, or anti-cyclic citrullinated peptide antibody levels were found. Survivors with sequelae showed significantly higher rheumatoid factor levels.
Conclusion: EBOV-specific CD8+ and CD4+ T-cell responses were significantly higher in Ebola survivors with post-Ebola syndrome. These findings suggest that pathogenesis may occur as an immune-mediated disease via virus-specific T-cell immune response or that persistent antigen exposure leads to increased and sustained T-cell responses.
(© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
References: J Infect Dis. 1999 Feb;179 Suppl 1:S13-4. (PMID: 9988158)
Int J Infect Dis. 2016 Feb;43:58-61. (PMID: 26711624)
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4719-24. (PMID: 25775592)
J Biol Chem. 1994 Feb 18;269(7):4974-8. (PMID: 8106472)
J Infect Dis. 1999 Feb;179 Suppl 1:S28-35. (PMID: 9988162)
Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7578-E7586. (PMID: 30038008)
BMJ Glob Health. 2018 Apr 1;3(2):e000410. (PMID: 29629189)
Am J Med. 1991 Nov;91(5):528-34. (PMID: 1951415)
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):246-51. (PMID: 17200302)
PLoS Pathog. 2020 Mar 6;16(3):e1008352. (PMID: 32142546)
J Virol Methods. 2010 Nov;169(2):365-74. (PMID: 20709108)
Ann Intern Med. 1995 Feb 1;122(3):169-73. (PMID: 7810933)
Rheumatology (Oxford). 2018 Jan 1;57(1):28-31. (PMID: 28379487)
Biomed Res Int. 2018 Jun 28;2018:1909410. (PMID: 30050920)
Virol J. 2013 Jul 26;10:244. (PMID: 23886073)
J Virol. 2020 Jun 1;94(12):. (PMID: 32269122)
Cell. 2019 May 30;177(6):1566-1582.e17. (PMID: 31104840)
Clin Infect Dis. 2016 Jun 15;62(12):1552-1555. (PMID: 27045122)
J Infect Dis. 1999 Feb;179 Suppl 1:S76-86. (PMID: 9988168)
Emerg Infect Dis. 2017 Jan;23(1):66-73. (PMID: 27983503)
Lancet Infect Dis. 2016 Mar;16(3):331-8. (PMID: 26725449)
Semin Arthritis Rheum. 2004 Jun;33(6):355-74. (PMID: 15190522)
N Engl J Med. 2019 Mar 7;380(10):924-934. (PMID: 30855742)
معلومات مُعتمدة: HHSN272201400048C United States AI NIAID NIH HHS; R01 AI123535 United States AI NIAID NIH HHS; U19 AI142790 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Ebola virus; T-cell response; post-Ebola sequelae
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Antigens, Viral)
تواريخ الأحداث: Date Created: 20200522 Date Completed: 20210309 Latest Revision: 20210522
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7529037
DOI: 10.1093/infdis/jiaa268
PMID: 32436943
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiaa268