دورية أكاديمية
أعرض في EDS

Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives.

التفاصيل البيبلوغرافية
العنوان: Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives.
المؤلفون: Slominski AT; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA. aslominski@uabmc.edu.; Veteran Administration Medical Center, Birmingham, Al, USA. aslominski@uabmc.edu., Chaiprasongsuk A; Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.; Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Janjetovic Z; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Kim TK; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Stefan J; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Slominski RM; Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA., Hanumanthu VS; Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA., Raman C; Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA., Qayyum S; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Song Y; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Song Y; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Al, USA., Panich U; Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Crossman DK; Department of Genetics, University of Alabama at Birmingham, Birmingham, Al, USA., Athar M; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Al, USA., Holick MF; Department of Medicines, Boston University, Boston, MA, USA., Jetten AM; Cell Biology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., Zmijewski MA; Department of Histology, Medical University of Gdansk, Gdansk, Poland., Zmijewski J; Department of Medicine, University of Alabama at Birmingham, Birmingham, Al, USA., Tuckey RC; School of Molecular Sciences, The University of Western Australia, Perth, WA, Australia.
المصدر: Cell biochemistry and biophysics [Cell Biochem Biophys] 2020 Jun; Vol. 78 (2), pp. 165-180. Date of Electronic Publication: 2020 May 22.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Totowa, NJ : Humana Press, c1996-
مواضيع طبية MeSH: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/*chemistry , Cholecalciferol/*chemistry , Cholesterol Side-Chain Cleavage Enzyme/*chemistry , Ergosterol/*chemistry , Radiation-Protective Agents/*chemistry, Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/metabolism ; Cell Line ; Cell Proliferation ; Cholecalciferol/analogs & derivatives ; DNA Damage/drug effects ; Ergosterol/analogs & derivatives ; Humans ; Keratinocytes/drug effects ; Melanocytes/drug effects ; Mitochondria/metabolism ; Receptors, Calcitriol/metabolism ; Signal Transduction ; Ultraviolet Rays
مستخلص: We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH) 2 D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH) 2 L3 and 24(OH)L3. CYP11A1 also acts on 7-dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH) 2 7DHC and 7-dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biologically active displaying anti-proliferative, anti-inflammatory, anti-cancer and pro-differentiation properties. Since the protective role of the classical form of vitamin D3 (1,25(OH) 2 D3) against UVB-induced damage is recognized, we recently tested whether novel CYP11A1-derived D3- and L3-hydroxyderivatives protect against UVB-induced damage in epidermal human keratinocytes and melanocytes. We found that along with 1,25(OH) 2 D3, CYP11A1-derived D3-hydroxyderivatives and L3 and its hydroxyderivatives exert photoprotective effects. These included induction of intracellular free radical scavenging and attenuation and repair of DNA damage. The protection of human keratinocytes against DNA damage included the activation of the NRF2-regulated antioxidant response, p53-phosphorylation and its translocation to the nucleus, and DNA repair induction. These data indicate that novel derivatives of vitamin D3 and lumisterol are promising photoprotective agents. However, detailed mechanisms of action, and the involvement of specific nuclear receptors, other vitamin D binding proteins or mitochondria, remain to be established.
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معلومات مُعتمدة: I01 BX004293 United States BX BLRD VA; R01 AR071189 United States AR NIAMS NIH HHS; R01 AR073004 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: DNA damage; Lumisterol; Oxidative stress; Skin; Ultraviolet B; Vitamin D
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Radiation-Protective Agents)
0 (Receptors, Calcitriol)
1C6V77QF41 (Cholecalciferol)
EC 1.14.15.18 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
EC 1.14.15.18 (CYP27B1 protein, human)
EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme)
Z30RAY509F (Ergosterol)
تواريخ الأحداث: Date Created: 20200523 Date Completed: 20210129 Latest Revision: 20240329
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7347247
DOI: 10.1007/s12013-020-00913-6
PMID: 32441029
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0283
DOI:10.1007/s12013-020-00913-6