دورية أكاديمية
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Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity.

التفاصيل البيبلوغرافية
العنوان: Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity.
المؤلفون: Carroll L; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK., Braeutigam S; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK., Dawes JM; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK., Krsnik Z; Croatian Institute for Brain Research, Centre of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb School of Medicine, Zagreb, Croatia., Kostovic I; Croatian Institute for Brain Research, Centre of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb School of Medicine, Zagreb, Croatia., Coutinho E; Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Dewing JM; Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK., Horton CA; Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, UK., Gomez-Nicola D; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK., Menassa DA; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK.; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
المصدر: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2021 Feb; Vol. 27 (1), pp. 10-29. Date of Electronic Publication: 2020 May 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9504819 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-4098 (Electronic) Linking ISSN: 10738584 NLM ISO Abbreviation: Neuroscientist Subsets: MEDLINE
أسماء مطبوعة: Publication: <2001->: Thousand Oaks, CA : Sage Publications
Original Publication: Baltimore, MD : Williams & Wilkins, c1995-
مواضيع طبية MeSH: Autism Spectrum Disorder*/etiology , Autism Spectrum Disorder*/immunology , Autism Spectrum Disorder*/physiopathology , Nerve Net*/growth & development , Nerve Net*/physiopathology , Neuronal Plasticity*/physiology , Peripheral Nervous System*/growth & development , Peripheral Nervous System*/physiopathology , Prefrontal Cortex*/growth & development , Prefrontal Cortex*/physiopathology, Animals ; Humans
مستخلص: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders of genetic and environmental etiologies. Some ASD cases are syndromic: associated with clinically defined patterns of somatic abnormalities and a neurobehavioral phenotype (e.g., Fragile X syndrome). Many cases, however, are idiopathic or non-syndromic. Such disorders present themselves during the early postnatal period when language, speech, and personality start to develop. ASDs manifest by deficits in social communication and interaction, restricted and repetitive patterns of behavior across multiple contexts, sensory abnormalities across multiple modalities and comorbidities, such as epilepsy among many others. ASDs are disorders of connectivity, as synaptic dysfunction is common to both syndromic and idiopathic forms. While multiple theories have been proposed, particularly in idiopathic ASDs, none address why certain brain areas (e.g., frontotemporal) appear more vulnerable than others or identify factors that may affect phenotypic specificity. In this hypothesis article, we identify possible routes leading to, and the consequences of, altered connectivity and review the evidence of central and peripheral synaptic dysfunction in ASDs. We postulate that phenotypic specificity could arise from aberrant experience-dependent plasticity mechanisms in frontal brain areas and peripheral sensory networks and propose why the vulnerability of these areas could be part of a model to unify preexisting pathophysiological theories.
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معلومات مُعتمدة: United Kingdom Wellcome Trust; MR/M02394X/1 United Kingdom MRC_ Medical Research Council; MR/P024572/1 United Kingdom MRC_ Medical Research Council; 203139/Z/16/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: autism spectrum disorders; connectivity; maternal immune activation; neurodevelopment; pain sensitivity; phenotypic specificity; synaptic dysfunction; synaptic plasticity
تواريخ الأحداث: Date Created: 20200523 Date Completed: 20211015 Latest Revision: 20220129
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7804368
DOI: 10.1177/1073858420921378
PMID: 32441222
قاعدة البيانات: MEDLINE
الوصف
تدمد:1089-4098
DOI:10.1177/1073858420921378