دورية أكاديمية
أعرض في EDS

Non-surgical oral hygiene interventions on disease activity of Rheumatoid arthritis patients with periodontitis: A randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Non-surgical oral hygiene interventions on disease activity of Rheumatoid arthritis patients with periodontitis: A randomized controlled trial.
المؤلفون: Buwembo W; Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda., Munabi IG; Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda., Kaddumukasa M; Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda., Kiryowa H; Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda., Mbabali M; Department of Dentistry, School of Health Sciences, Makerere University College of Health Sciences, Kampala Uganda., Nankya E; Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University, USA., Johnson WE; Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University, USA., Okello E; Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda., Sewankambo NK; Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda.
المصدر: Journal of dental research, dental clinics, dental prospects [J Dent Res Dent Clin Dent Prospects] 2020 Winter; Vol. 14 (1), pp. 26-36.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Tabriz University of Medical Sciences, Faculty of Dentistry Country of Publication: Iran NLM ID: 101576035 Publication Model: Print Cited Medium: Print ISSN: 2008-210X (Print) Linking ISSN: 2008210X NLM ISO Abbreviation: J Dent Res Dent Clin Dent Prospects Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Tabriz : Tabriz University of Medical Sciences, Faculty of Dentistry
مستخلص: Background. Periodontitis and rheumatoid arthritis have similar epidemiology and pathophysiology. Understanding the interaction between these two diseases is vital in our settings. We set out to assess the effect of oral hygiene interventions on disease activity of rheumatoid arthritis patients with periodontitis in Kampala, Uganda. Methods. Fifty-eight patients attending an arthritis clinic with rheumatoid arthritis and periodontitis were randomly assigned to either an intervention group or a control group. Patients diagnosed with rheumatoid arthritis at least two years before, who were on the same medication, dose, or formulation for RA treatment during the preceding three months, were included. The patients were >18 years of age, would be available for all the study visits in the next six months, had at least six natural teeth, had periodontal disease classified as Dutch Periodontal Index (DPSI) >3 and provided written informed consent. Those who had a chronic disorder requiring chronic or intermittent use of antibiotics, were pregnant, were lactating, or had intent to become pregnant were excluded. The primary outcome measure was a change in Disease Activity Score of 28 Joints (DAS28 score) in two 3-month follow-up periods after the intervention. The secondary outcome measure was a change in periodontal status. Results. There was a statistically significant improvement in the DAS-28 score in both the intervention and control arms during the follow-up period (P<0.01). The participants carrying more than one bacterial species had worse DAS-28 scores. Conclusion. Oral hygiene interventions given to RA patients could drastically improve their RA treatment outcomes, especially in resource-limited settings.
(© 2020 Buwembo et al.)
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معلومات مُعتمدة: D43 TW010132 United States TW FIC NIH HHS
فهرسة مساهمة: Keywords: DAS-28 score; periodontitis; periodontopathogenic bacteria; pocket depth; rheumatoid arthritis
تواريخ الأحداث: Date Created: 20200527 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7235694
DOI: 10.34172/joddd.2020.004
PMID: 32454955
قاعدة البيانات: MEDLINE
الوصف
تدمد:2008-210X
DOI:10.34172/joddd.2020.004