دورية أكاديمية
أعرض في EDS

Anti-hypertensive effect of hydrogen peroxide acting centrally.

التفاصيل البيبلوغرافية
العنوان: Anti-hypertensive effect of hydrogen peroxide acting centrally.
المؤلفون: Lauar MR; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil., Blanch GT; School of Medicine, Pharmacy and Biomedicine, Pontifical Catholic University of Goias, Goiania, GO, Brazil., Colombari DSA; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil., Colombari E; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil., De Paula PM; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil., De Luca LA Jr; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil., Menani JV; Department of Physiology and Pathology, Dentistry School, São Paulo State University (UNESP), Araraquara, SP, Brazil. jv.menani@unesp.br.
المصدر: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2020 Nov; Vol. 43 (11), pp. 1192-1203. Date of Electronic Publication: 2020 May 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2009- : London : Nature Publishing Group
Original Publication: Toyonaka, Japan : The Society, c1992-2003
مواضيع طبية MeSH: Amitrole/*administration & dosage , Blood Pressure/*drug effects , Hydrogen Peroxide/*administration & dosage , Hypertension/*drug therapy , Oxidants/*administration & dosage, Angiotensin II ; Animals ; Catalase/antagonists & inhibitors ; Drug Evaluation, Preclinical ; Infusions, Intraventricular ; Male ; Rats, Inbred SHR
مستخلص: Intracerebroventricular (icv) injection of hydrogen peroxide (H 2 O 2 ) or the increase of endogenous H 2 O 2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H 2 O 2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H 2 O 2 (5 μmol/1 μl) or ATZ (5 nmol/1 μl) icv reduced the pressor responses to ANG II (50 ng/1 µl) icv in SHRs (11 ± 3 and 17 ± 4 mmHg, respectively, vs. 35 ± 6 mmHg) and 2K1C hypertensive rats (3 ± 1 and 16 ± 3 mmHg, respectively, vs. 26 ± 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H 2 O 2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H 2 O 2 icv and ATZ iv alone or combined and in SHRs treated with H 2 O 2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H 2 O 2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.
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فهرسة مساهمة: Keywords: 2K1C hypertension; Angiotensin; Catalase inhibition; H2O2; Reactive oxygen species; SHR
المشرفين على المادة: 0 (Oxidants)
11128-99-7 (Angiotensin II)
BBX060AN9V (Hydrogen Peroxide)
EC 1.11.1.6 (Catalase)
ZF80H5GXUF (Amitrole)
تواريخ الأحداث: Date Created: 20200529 Date Completed: 20211011 Latest Revision: 20211011
رمز التحديث: 20231215
DOI: 10.1038/s41440-020-0474-5
PMID: 32461634
قاعدة البيانات: MEDLINE
الوصف
تدمد:1348-4214
DOI:10.1038/s41440-020-0474-5