دورية أكاديمية
Fabclavine diversity in Xenorhabdus bacteria.
| العنوان: | Fabclavine diversity in Xenorhabdus bacteria. |
|---|---|
| المؤلفون: | Wenski SL; Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Cimen H; Adnan Menderes University, Faculty of Arts and Sciences, Department of Biology, 09010 Aydin, Turkey., Berghaus N; Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Fuchs SW; Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Hazir S; Adnan Menderes University, Faculty of Arts and Sciences, Department of Biology, 09010 Aydin, Turkey., Bode HB; Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universität Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany.; Senckenberg Gesellschaft für Naturforschung, Senckenberganlage 25, 60325 Frankfurt am Main, Germany. |
| المصدر: | Beilstein journal of organic chemistry [Beilstein J Org Chem] 2020 May 07; Vol. 16, pp. 956-965. Date of Electronic Publication: 2020 May 07 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Beilstein-Institut Country of Publication: Germany NLM ID: 101250746 Publication Model: eCollection Cited Medium: Print ISSN: 1860-5397 (Print) Linking ISSN: 18605397 NLM ISO Abbreviation: Beilstein J Org Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: [Frankfurt, Germany] : Beilstein-Institut Original Publication: [Frankfurt, Germany] : [London] : Beilstein-Institut ; in cooperation with BioMed Central, [2005]- |
| مستخلص: | The global threat of multiresistant pathogens has to be answered by the development of novel antibiotics. Established antibiotic applications are often based on so-called secondary or specialized metabolites (SMs), identified in large screening approaches. To continue this successful strategy, new sources for bioactive compounds are required, such as the bacterial genera Xenorhabdus or Photorhabdus . In these strains, fabclavines are widely distributed SMs with a broad-spectrum bioactivity. Fabclavines are hybrid SMs derived from nonribosomal peptide synthetases (NRPS), polyunsaturated fatty acid (PUFA), and polyketide synthases (PKS). Selected Xenorhabdus and Photorhabdus mutant strains were generated applying a chemically inducible promoter in front of the suggested fabclavine ( fcl ) biosynthesis gene cluster (BGC), followed by the analysis of the occurring fabclavines. Subsequently, known and unknown derivatives were identified and confirmed by MALDI-MS and MALDI-MS 2 experiments in combination with an optimized sample preparation. This led to a total number of 22 novel fabclavine derivatives in eight strains, increasing the overall number of fabclavines to 32. Together with the identification of fabclavines as major antibiotics in several entomopathogenic strains, our work lays the foundation for the rapid fabclavine identification and dereplication as the basis for future work of this widespread and bioactive SM class. (Copyright © 2020, Wenski et al.; licensee Beilstein-Institut.) |
| References: | Cell Chem Biol. 2016 Apr 21;23(4):462-71. (PMID: 27105282) Science. 2001 Jul 13;293(5528):290-3. (PMID: 11452122) PLoS One. 2013;8(1):e54143. (PMID: 23349809) J Invertebr Pathol. 2017 Oct;149:21-28. (PMID: 28712711) Angew Chem Int Ed Engl. 2009;48(26):4688-716. (PMID: 19514004) Molecules. 2016 Jun 24;21(7):. (PMID: 27347911) Microbiology (Reading). 2005 Aug;151(Pt 8):2543-2550. (PMID: 16079333) J Antibiot (Tokyo). 2013 Oct;66(10):617-20. (PMID: 23756685) J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):565-572. (PMID: 30610410) Mol Pharm. 2008 Mar-Apr;5(2):191-211. (PMID: 18217713) Chem Sci. 2015 Feb 1;6(2):923-929. (PMID: 29560178) Angew Chem Int Ed Engl. 2002 Jun 3;41(11):1866-9. (PMID: 19750617) Chembiochem. 2014 Mar 3;15(4):512-6. (PMID: 24532262) Nat Chem. 2017 Apr;9(4):379-386. (PMID: 28338679) Nat Prod Rep. 2018 Apr 25;35(4):309-335. (PMID: 29359226) Beilstein J Org Chem. 2015 Dec 09;11:2493-508. (PMID: 26734097) Front Microbiol. 2019 Nov 22;10:2672. (PMID: 31824457) Health Secur. 2015 May-Jun;13(3):153-5. (PMID: 26042858) BMC Genomics. 2017 Dec 01;18(1):927. (PMID: 29191166) IUBMB Life. 2014 Sep;66(9):587-95. (PMID: 25278375) Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3463-7. (PMID: 26833898) J Invertebr Pathol. 2019 Jan;160:61-66. (PMID: 30528928) Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1587-1604. (PMID: 28526268) Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18957-18963. (PMID: 31693786) Chem Commun (Camb). 2011 Jul 21;47(27):7559-66. (PMID: 21594283) Org Lett. 2018 Sep 7;20(17):5116-5120. (PMID: 30095261) Nat Microbiol. 2017 Dec;2(12):1676-1685. (PMID: 28993611) J Am Chem Soc. 2012 Aug 1;134(30):12382-5. (PMID: 22799266) Appl Microbiol Biotechnol. 2000 Jul;54(1):9-13. (PMID: 10951998) Nat Chem. 2018 Mar;10(3):275-281. (PMID: 29461518) Curr Opin Chem Biol. 2009 Apr;13(2):224-30. (PMID: 19345136) Chembiochem. 2007 Sep 24;8(14):1721-8. (PMID: 17722122) Org Lett. 2011 Oct 7;13(19):5144-7. (PMID: 21888371) Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S5-12. (PMID: 16323120) Chembiochem. 2015 May 4;16(7):1115-9. (PMID: 25826784) J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):281-299. (PMID: 30484124) Chem Biol. 2013 Jun 20;20(6):764-71. (PMID: 23790487) Mol Plant Microbe Interact. 2011 Oct;24(10):1156-64. (PMID: 21899437) Org Biomol Chem. 2011 May 7;9(9):3130-2. (PMID: 21423922) Front Microbiol. 2017 Jun 28;8:1142. (PMID: 28702004) Mol Microbiol. 2007 Apr;64(2):260-8. (PMID: 17493120) Chembiochem. 2005 Feb;6(2):375-85. (PMID: 15651040) J Nat Prod. 1991 May-Jun;54(3):785-95. (PMID: 1955881) J Ind Microbiol Biotechnol. 2014 Feb;41(2):185-201. (PMID: 23990168) Angew Chem Int Ed Engl. 2014 Mar 10;53(11):3011-4. (PMID: 24519911) |
| فهرسة مساهمة: | Keywords: NRPS-PKS hybrid; Xenorhabdus; antibiotic; fabclavine; secondary metabolite |
| تواريخ الأحداث: | Date Created: 20200529 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7214866 |
| DOI: | 10.3762/bjoc.16.84 |
| PMID: | 32461774 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1860-5397 |
|---|---|
| DOI: | 10.3762/bjoc.16.84 |