دورية أكاديمية
The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice.
| العنوان: | The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice. |
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| المؤلفون: | Bampi SR; Postgraduate Program in Biotechnology, Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Casaril AM; Postgraduate Program in Biotechnology, Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Fronza MG; Postgraduate Program in Biotechnology, Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Domingues M; Postgraduate Program in Biotechnology, Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Vieira B; Postgraduate Program in Chemistry, Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, RS, Brazil., Begnini KR; Postgraduate Program in Biotechnology, Molecular and Cellular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Seixas FK; Postgraduate Program in Biotechnology, Molecular and Cellular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Collares TV; Postgraduate Program in Biotechnology, Molecular and Cellular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Lenardão EJ; Postgraduate Program in Chemistry, Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, RS, Brazil., Savegnago L; Postgraduate Program in Biotechnology, Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br. |
| المصدر: | Brain research bulletin [Brain Res Bull] 2020 Aug; Vol. 161, pp. 158-165. Date of Electronic Publication: 2020 May 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Elsevier Science Original Publication: Phoenix, N. Y. ANKHO International Inc. |
| مواضيع طبية MeSH: | Antidepressive Agents/*administration & dosage , Antioxidants/*administration & dosage , Depression/*drug therapy , Inflammation Mediators/*antagonists & inhibitors , Oxidative Stress/*drug effects , Selenium Compounds/*administration & dosage , Streptozocin/*toxicity, Animals ; Antidepressive Agents/chemistry ; Antioxidants/chemistry ; Brain/drug effects ; Brain/metabolism ; Depression/chemically induced ; Depression/metabolism ; Inflammation Mediators/metabolism ; Injections, Intraventricular ; Male ; Mice ; Oxidative Stress/physiology ; Selenium Compounds/chemistry ; Streptozocin/administration & dosage |
| مستخلص: | Major depressive disorder (MDD) is a chronic mental illness affecting a wide range of people worldwide. The pathophysiology of MDD is not completely elucidated, but it is believed that oxidative stress and neuroinflammation are involved. In light with this, the aim of the present study was to investigate whether a single administration of the antioxidant 1-methyl-3-(phenylselanyl)-1H-indole (MFSeI) was able to reverse the streptozotocin-induced depression-like behavior, oxidative stress, and neuroinflammation in mice. MFSeI (10 mg/kg) was administered intragastrically (i.g.) 24 h after the intracerebroventricular injection of STZ (0.2 mg/4 μL/per mouse). Thirty minutes after MFSeI administration, behavioral tests and neurochemical analyses were performed. Fluoxetine (10 mg/kg, i.g.) was used as a positive control. MFSeI and fluoxetine were able to reverse the STZ-induced depression-like behavior, as evidenced by decreased immobility time in the forced swimming test and increased grooming time in the splash test. Mechanistically, MFSeI reversed the increased levels of reactive species and lipid peroxidation in the prefrontal cortices and hippocampi of STZ-treated mice. Additionally, neuroinflammation (i.e. expression of NF-κB, IL-1β, and TNF-α) and the reduced mRNA levels of BDNF in the and hippocampi of depressed mice were reversed by treatment with MFSeI. Fluoxetine did not improve the STZ-induced alterations at the levels of reactive species, NF-κB and BDNF in the prefrontal cortices neither the levels of TNF-α in both brain regions. Together, these data suggest that the MFSeI may be a promising compound with antidepressant-like action, reducing oxidative stress and modulating inflammatory pathways in the brain of depressed mice. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Depression; Indole; Neuroinflammation; Organoselenium; streptozotocin |
| المشرفين على المادة: | 0 (Antidepressive Agents) 0 (Antioxidants) 0 (Inflammation Mediators) 0 (Selenium Compounds) 5W494URQ81 (Streptozocin) |
| تواريخ الأحداث: | Date Created: 20200530 Date Completed: 20210929 Latest Revision: 20210929 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.brainresbull.2020.05.008 |
| PMID: | 32470357 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2747 |
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| DOI: | 10.1016/j.brainresbull.2020.05.008 |