دورية أكاديمية
أعرض في EDS

Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure.

التفاصيل البيبلوغرافية
العنوان: Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure.
المؤلفون: Park S; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California., Ranjbarvaziri S; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California., Zhao P; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California., Ardehali R; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular Biology Institute, UCLA, Los Angeles, California.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Apr 15; Vol. 5 (5), pp. 432-443. Date of Electronic Publication: 2020 Apr 15 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: Cardiac fibrosis is a pathological process associated with various forms of heart failure. This study identified latent transforming growth factor-β binding protein 2, cartilage oligomeric matrix protein, and cartilage intermediate layer protein 1 as potential biomarkers for cardiac fibrosis. All 3 encoded proteins showed increased expression in fibroblasts after transforming growth factor-β stimulation in vitro and localized specifically to fibrotic regions in vivo. Of the 3, only the full-length cartilage intermediate layer protein 1 showed a significant decrease in circulating levels in patients with heart failure compared with healthy volunteers. Further studies on these 3 proteins will lead to a better understanding of their biomarker potential for cardiac fibrosis.
(© 2020 The Authors.)
التعليقات: Comment in: JACC Basic Transl Sci. 2020 May 25;5(5):444-446. (PMID: 32479564)
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معلومات مُعتمدة: DP2 HL127728 United States HL NHLBI NIH HHS; T32 HL069766 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: CFB, cardiac fibroblast; CILP, cartilage intermediate layer protein 1; COMP, cartilage oligomeric matrix protein; ECM, extracellular matrix; ELISA, enzyme-linked immunosorbent assay; Ltbp2, latent transforming growth factor-β binding protein 2; PCR, polymerase chain reaction; RNA, ribonucleic acid; TAC, transverse aortic constriction; TGF, transforming growth factor; biomarker; cardiac fibrosis; extracellular matrix protein; heart failure
تواريخ الأحداث: Date Created: 20200602 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC7251193
DOI: 10.1016/j.jacbts.2020.01.016
PMID: 32478206
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2020.01.016