تقرير
Type 3 hypersensitivity in COVID-19 vasculitis.
| العنوان: | Type 3 hypersensitivity in COVID-19 vasculitis. |
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| المؤلفون: | Roncati L; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy. Electronic address: roncati.luca@aou.mo.it., Ligabue G; Nephrology Lab, University of Modena and Reggio Emilia, Modena, Italy., Fabbiani L; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy., Malagoli C; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy., Gallo G; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy., Lusenti B; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy., Nasillo V; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy., Manenti A; Department of Surgery, University of Modena and Reggio Emilia, Modena, Italy., Maiorana A; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy. |
| المصدر: | Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Aug; Vol. 217, pp. 108487. Date of Electronic Publication: 2020 May 29. |
| نوع المنشور: | Case Reports; Letter |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Orlando, FL : Academic Press, c1999- |
| مواضيع طبية MeSH: | Betacoronavirus/*pathogenicity , Coronavirus Infections/*immunology , Cytokine Release Syndrome/*immunology , Immune Complex Diseases/*immunology , Pneumonia, Viral/*immunology , Severe Acute Respiratory Syndrome/*immunology , Th2 Cells/*immunology , Vasculitis/*immunology, Aged ; Antibodies, Viral/biosynthesis ; Antigen-Antibody Complex/biosynthesis ; Betacoronavirus/immunology ; Blood Vessels/immunology ; Blood Vessels/pathology ; Blood Vessels/virology ; COVID-19 ; Complement C3/biosynthesis ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Cytokine Release Syndrome/complications ; Cytokine Release Syndrome/virology ; Disease Progression ; Endothelial Cells/immunology ; Endothelial Cells/pathology ; Endothelial Cells/virology ; Humans ; Immune Complex Diseases/complications ; Immune Complex Diseases/virology ; Immunity, Humoral ; Immunoglobulin G/biosynthesis ; Immunoglobulin M/biosynthesis ; Interleukin-6/biosynthesis ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/virology ; Th2 Cells/pathology ; Th2 Cells/virology ; Vasculitis/complications ; Vasculitis/virology |
| مستخلص: | Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels. Competing Interests: Declaration of Competing Interest None of the authors has any financial conflict of interest to disclose. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Hum Cell. 2022 Dec 7;:. (PMID: 36478089) |
| References: | Ann Hematol. 2020 Jun;99(6):1419-1420. (PMID: 32382776) Clin Immunol. 2020 Jun;215:108450. (PMID: 32360516) Arthritis Res Ther. 2007;9 Suppl 2:S9. (PMID: 17767747) Med Hypotheses. 2020 Sep;142:109824. (PMID: 32408068) Med Hypotheses. 2020 Mar 21;140:109686. (PMID: 32220710) Clin Infect Dis. 2001 Jan;32(1):76-102. (PMID: 11118387) J Med Virol. 2006 Jan;78(1):1-8. (PMID: 16299724) Lancet. 2003 May 24;361(9371):1767-72. (PMID: 12781535) Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):103-9. (PMID: 22034510) Br J Haematol. 2020 Jun;189(5):846-847. (PMID: 32304577) |
| فهرسة مساهمة: | Keywords: Coronavirus disease 2019 (COVID-19); Immune complex disease; Interleukin-6 (IL-6); Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); Type III hypersensitivity; Vasculitis |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antigen-Antibody Complex) 0 (Complement C3) 0 (IL6 protein, human) 0 (Immunoglobulin G) 0 (Immunoglobulin M) 0 (Interleukin-6) |
| تواريخ الأحداث: | Date Created: 20200602 Date Completed: 20200721 Latest Revision: 20230606 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7256503 |
| DOI: | 10.1016/j.clim.2020.108487 |
| PMID: | 32479986 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1521-7035 |
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| DOI: | 10.1016/j.clim.2020.108487 |