دورية أكاديمية
أعرض في EDS

Group V secreted phospholipase A 2 plays a protective role against aortic dissection.

التفاصيل البيبلوغرافية
العنوان: Group V secreted phospholipase A 2 plays a protective role against aortic dissection.
المؤلفون: Watanabe K; Department of Internal Medicine II, University of Yamanashi, Department of Internal Medicine II, Chuo, Yamanashi Japan.; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Taketomi Y; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Miki Y; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Kugiyama K; Department of Internal Medicine II, University of Yamanashi, Department of Internal Medicine II, Chuo, Yamanashi Japan kugiyama@yamanashi.ac.jp makmurak@m.u-tokyo.ac.jp.; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan., Murakami M; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan kugiyama@yamanashi.ac.jp makmurak@m.u-tokyo.ac.jp.; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan.; FORCE, Japan Agency for Medical Research and Development, Tokyo, Japan.
المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Jul 24; Vol. 295 (30), pp. 10092-10111. Date of Electronic Publication: 2020 Jun 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
مواضيع طبية MeSH: Endoplasmic Reticulum Stress*, Aortic Dissection/*metabolism , Aorta/*metabolism , Group V Phospholipases A2/*metabolism , Phospholipids/*metabolism, Aortic Dissection/chemically induced ; Aortic Dissection/genetics ; Angiotensin II/adverse effects ; Angiotensin II/pharmacology ; Animals ; Aorta/pathology ; Disease Models, Animal ; Group V Phospholipases A2/genetics ; Linoleic Acid/genetics ; Linoleic Acid/metabolism ; Mice ; Mice, Knockout ; Oleic Acid/genetics ; Oleic Acid/metabolism ; Phospholipids/genetics
مستخلص: Aortic dissection is a life-threatening aortopathy involving separation of the aortic wall, whose underlying mechanisms are still incompletely understood. Epidemiological evidence suggests that unsaturated fatty acids improve cardiovascular health. Here, using quantitative RT-PCR, histological analyses, magnetic cell sorting and flow cytometry assays, and MS-based lipidomics, we show that the activity of a lipid-metabolizing enzyme, secreted phospholipase A 2 group V (sPLA 2 -V), protects against aortic dissection by endogenously mobilizing vasoprotective lipids. Global and endothelial cell-specific sPLA 2 -V-deficient mice frequently developed aortic dissection shortly after infusion of angiotensin II (AT-II). We observed that in the AT-II-treated aorta, endothelial sPLA 2 -V mobilized oleic and linoleic acids, which attenuated endoplasmic reticulum stress, increased the expression of lysyl oxidase, and thereby stabilized the extracellular matrix in the aorta. Of note, dietary supplementation with oleic or linoleic acid reversed the increased susceptibility of sPLA 2 -V-deficient mice to aortic dissection. These findings reveal an unexplored functional link between sPLA 2 -driven phospholipid metabolism and aortic stability, possibly contributing to the development of improved diagnostic and/or therapeutic strategies for preventing aortic dissection.
Competing Interests: Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
(© 2020 Watanabe et al.)
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فهرسة مساهمة: Keywords: animal model; aortic dissection; aortopathy; cardiovascular disease; cardiovascular disorder; extracellular matrix; fatty acid; gene knockout; lipidomics; lysyl oxidase; phospholipase; phospholipase A2; phospholipid metabolism
المشرفين على المادة: 0 (Phospholipids)
11128-99-7 (Angiotensin II)
2UMI9U37CP (Oleic Acid)
9KJL21T0QJ (Linoleic Acid)
EC 3.1.1.4 (Group V Phospholipases A2)
تواريخ الأحداث: Date Created: 20200603 Date Completed: 20210113 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7383374
DOI: 10.1074/jbc.RA120.013753
PMID: 32482892
قاعدة البيانات: MEDLINE
الوصف
تدمد:1083-351X
DOI:10.1074/jbc.RA120.013753