دورية أكاديمية
أعرض في EDS

Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma.

التفاصيل البيبلوغرافية
العنوان: Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma.
المؤلفون: Ramzy GM; Molecular Pharmacology Group, School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.; Translational Research Center in Oncohaematology, University of Geneva, 1211 Geneva, Switzerland., Koessler T; Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland., Ducrey E; Molecular Pharmacology Group, School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.; Translational Research Center in Oncohaematology, University of Geneva, 1211 Geneva, Switzerland., McKee T; Division of Clinical Pathology, Diagnostic Department, University Hospitals of Geneva (HUG), 1211 Geneva, Switzerland., Ris F; Translational Department of Digestive and Transplant Surgery, Geneva University Hospitals and Faculty of Medicine, 1211 Geneva, Switzerland., Buchs N; Translational Department of Digestive and Transplant Surgery, Geneva University Hospitals and Faculty of Medicine, 1211 Geneva, Switzerland., Rubbia-Brandt L; Division of Clinical Pathology, Diagnostic Department, University Hospitals of Geneva (HUG), 1211 Geneva, Switzerland., Dietrich PY; Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland., Nowak-Sliwinska P; Molecular Pharmacology Group, School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.; Translational Research Center in Oncohaematology, University of Geneva, 1211 Geneva, Switzerland.
المصدر: Cancers [Cancers (Basel)] 2020 May 31; Vol. 12 (6). Date of Electronic Publication: 2020 May 31.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Lack of relevant preclinical models that reliably recapitulate the complexity and heterogeneity of human cancer has slowed down the development and approval of new anti-cancer therapies. Even though two-dimensional in vitro culture models remain widely used, they allow only partial cell-to-cell and cell-to-matrix interactions and therefore do not represent the complex nature of the tumor microenvironment. Therefore, better models reflecting intra-tumor heterogeneity need to be incorporated in the drug screening process to more reliably predict the efficacy of drug candidates. Classic methods of modelling colorectal carcinoma (CRC), while useful for many applications, carry numerous limitations. In this review, we address the recent advances in in vitro CRC model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
Competing Interests: The authors declare no competing interests.
References: Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E7-15. (PMID: 26668389)
Cell. 2014 Aug 28;158(5):1110-1122. (PMID: 25171411)
Br J Cancer. 2009 Aug 4;101(3):473-82. (PMID: 19603013)
Adv Ther. 2017 Oct;34(10):2232-2273. (PMID: 28983798)
Sci Adv. 2019 May 22;5(5):eaaw1317. (PMID: 31131324)
Cancer Treat Rev. 2016 May;46:20-6. (PMID: 27057657)
J Clin Oncol. 2019 Jun 10;37(17):1460-1469. (PMID: 30892987)
Nat Rev Clin Oncol. 2018 Jun;15(6):353-365. (PMID: 29599476)
Cell. 2014 Sep 25;159(1):176-187. (PMID: 25201530)
Oncol Rep. 2020 Feb;43(2):405-414. (PMID: 31894341)
Gut. 2019 Dec;68(12):2179-2185. (PMID: 31488504)
Oncotarget. 2018 Apr 24;9(31):21950-21964. (PMID: 29774115)
Microsyst Nanoeng. 2019 Feb 25;5:8. (PMID: 31057935)
Oncotarget. 2016 Oct 4;7(40):66212-66225. (PMID: 27517155)
Nat Rev Cancer. 2019 Feb;19(2):65-81. (PMID: 30647431)
Cancer Discov. 2011 Nov;1(6):508-23. (PMID: 22586653)
Lancet Oncol. 2016 Dec;17(12):e542-e551. (PMID: 27924752)
PLoS One. 2017 Sep 6;12(9):e0183074. (PMID: 28877221)
Cancer Res. 2015 Mar 1;75(5):892-901. (PMID: 25592149)
Radiographics. 2018 May-Jun;38(3):740-765. (PMID: 29676964)
Cancer Res. 2006 Jul 15;66(14):7370-7. (PMID: 16849589)
Phys Biol. 2014 Nov 26;11(6):065003. (PMID: 25427213)
PLoS One. 2016 Jan 08;11(1):e0146052. (PMID: 26745821)
SLAS Discov. 2017 Jun;22(5):456-472. (PMID: 28520521)
Sci Rep. 2018 Feb 16;8(1):3171. (PMID: 29453454)
Mol Cancer Ther. 2017 Jul;16(7):1435-1442. (PMID: 28468778)
J Am Assoc Lab Anim Sci. 2015 Mar;54(2):120-32. (PMID: 25836957)
Methods Mol Biol. 2018;1765:307-314. (PMID: 29589317)
iScience. 2018 Apr 27;2:156-167. (PMID: 30428372)
Int J Clin Oncol. 2017 Jun;22(3):421-430. (PMID: 28238187)
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20035-40. (PMID: 23169653)
Gastroenterology. 2011 Nov;141(5):1762-72. (PMID: 21889923)
Tissue Eng Part A. 2010 Apr;16(4):1363-8. (PMID: 19912046)
Biotechnol Adv. 2017 Mar - Apr;35(2):217-239. (PMID: 28057483)
Nat Rev Drug Discov. 2015 Apr;14(4):248-60. (PMID: 25792263)
Nat Methods. 2014 Apr;11(4):417-22. (PMID: 24584193)
Nat Rev Clin Oncol. 2017 Aug;14(8):463-482. (PMID: 28374786)
J Biotechnol. 2015 Jul 10;205:14-23. (PMID: 25746901)
Methods Mol Biol. 2016;1422:33-40. (PMID: 27246020)
Drug Discov Today. 2016 Sep;21(9):1399-1411. (PMID: 27422270)
Nat Protoc. 2017 Feb;12(2):439-451. (PMID: 28125105)
Nature. 2012 Jan 26;483(7387):100-3. (PMID: 22281684)
Biochem Biophys Res Commun. 2013 Mar 22;432(4):558-63. (PMID: 23485463)
Lab Invest. 2020 Jan;100(1):27-37. (PMID: 31409886)
Gut. 2017 Oct;66(10):1802-1810. (PMID: 27456153)
In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):114-22. (PMID: 19915935)
Drug Discov Today. 2017 Sep;22(9):1392-1399. (PMID: 28390929)
Nat Cell Biol. 2019 Jun;21(6):778-790. (PMID: 31160710)
Nat Biotechnol. 2014 Aug;32(8):773-85. (PMID: 25093879)
J Thorac Oncol. 2018 Sep;13(9):1248-1268. (PMID: 29885479)
Sci Rep. 2016 Jan 11;6:19103. (PMID: 26752500)
Nat Med. 2015 Nov;21(11):1318-25. (PMID: 26479923)
Oncotarget. 2015 Nov 10;6(35):37695-705. (PMID: 26462177)
J Clin Oncol. 2015 Dec 1;33(34):4032-8. (PMID: 26460303)
Am J Pathol. 2007 Mar;170(3):1077-85. (PMID: 17322390)
Science. 2019 May 3;364(6439):458-464. (PMID: 31048486)
Cancers (Basel). 2018 May 28;10(6):. (PMID: 29843359)
Front Oncol. 2018 Oct 02;8:400. (PMID: 30333957)
Drugs. 2018 Feb;78(2):155-162. (PMID: 29350327)
Cell. 2019 Jan 10;176(1-2):98-112.e14. (PMID: 30633912)
Assay Drug Dev Technol. 2014 May;12(4):207-18. (PMID: 24831787)
Biomaterials. 2005 Jan;26(1):93-9. (PMID: 15193884)
Tumori. 2009 May-Jun;95(3):343-7. (PMID: 19688974)
Sci Rep. 2018 Oct 18;8(1):15423. (PMID: 30337660)
Cell Mol Gastroenterol Hepatol. 2018 Apr 24;5(4):659-668. (PMID: 29713674)
SLAS Technol. 2017 Jun;22(3):254-275. (PMID: 28027446)
Sci Transl Med. 2013 Apr 10;5(180):180ra48. (PMID: 23576814)
Dis Model Mech. 2019 Jul 29;12(7):. (PMID: 31383635)
Front Bioeng Biotechnol. 2018 Jul 17;6:97. (PMID: 30065926)
Bioessays. 2015 Aug;37(8):909-20. (PMID: 26115037)
Sci Rep. 2018 Feb 13;8(1):2871. (PMID: 29440725)
Cell. 2015 May 7;161(4):933-45. (PMID: 25957691)
J Biol Eng. 2014 Apr 01;8:9. (PMID: 24690469)
J Immunother Cancer. 2019 Mar 14;7(1):74. (PMID: 30871626)
Cells. 2019 Apr 30;8(5):. (PMID: 31052294)
Curr Opin Genet Dev. 2018 Oct;52:117-122. (PMID: 30261425)
Cell Mol Life Sci. 2016 Nov;73(21):3971-89. (PMID: 27147463)
Sci Rep. 2015 Dec 09;5:17187. (PMID: 26647838)
Adv Drug Deliv Rev. 2014 Dec 15;79-80:145-54. (PMID: 24819215)
Drug Discov Today. 2018 Mar;23(3):745-753. (PMID: 29031620)
Cell Rep. 2019 Jan 15;26(3):608-623.e6. (PMID: 30650355)
Sci Rep. 2018 Feb 21;8(1):3395. (PMID: 29467373)
Biomed Res Int. 2015;2015:618021. (PMID: 26075250)
Int J Cancer. 2011 Jul 1;129(1):245-55. (PMID: 21170960)
Cell Syst. 2018 Nov 28;7(5):496-509.e6. (PMID: 30414924)
Mol Oncol. 2016 Mar;10(3):395-407. (PMID: 26795350)
Cancers (Basel). 2019 Oct 22;11(10):. (PMID: 31652588)
Cell Biol Toxicol. 2005 Jan;21(1):1-26. (PMID: 15868485)
Future Sci OA. 2017 Mar 27;3(2):FSO190. (PMID: 28670477)
Anticancer Res. 2017 Jul;37(7):3405-3412. (PMID: 28668828)
Mol Med Rep. 2019 Jun;19(6):4623-4630. (PMID: 31059040)
Br J Cancer. 2015 Feb 3;112(3):539-46. (PMID: 25535733)
Cell Tissue Res. 2008 Jun;332(3):489-98. (PMID: 18386065)
Nat Rev Cancer. 2018 Jul;18(7):407-418. (PMID: 29692415)
World J Stem Cells. 2015 Mar 26;7(2):461-9. (PMID: 25815129)
Expert Opin Drug Discov. 2015;10(11):1217-29. (PMID: 26295972)
Clin Colorectal Cancer. 2018 Jun;17(2):e189-e199. (PMID: 29233603)
PLoS One. 2012;7(6):e38422. (PMID: 22675560)
Sci Rep. 2019 Apr 17;9(1):6193. (PMID: 30996238)
Expert Opin Drug Discov. 2018 Dec;13(12):1115-1129. (PMID: 30384781)
Nat Med. 2014 Jul;20(7):769-77. (PMID: 24859528)
Curr Med Chem. 2017;24(15):1537-1557. (PMID: 28079003)
Cell Rep. 2017 Dec 12;21(11):3298-3309. (PMID: 29241554)
Cancer Cell Int. 2017 Dec 20;17:122. (PMID: 29296105)
Br J Cancer. 2011 Sep 6;105(6):847-53. (PMID: 21829190)
Lab Chip. 2016 Jul 5;16(14):2719-29. (PMID: 27332143)
Nat Rev Clin Oncol. 2011 Mar 30;8(4):189-90. (PMID: 21448176)
Int J Mol Sci. 2017 Jan 31;18(2):. (PMID: 28146134)
Biotechnol Adv. 2018 Jan - Feb;36(1):132-149. (PMID: 29056474)
Cancer Treat Rev. 2018 Nov;70:1-8. (PMID: 30053724)
Mol Cell. 2015 Nov 19;60(4):547-60. (PMID: 26590714)
Lancet Oncol. 2012 Nov;13(11):1152-60. (PMID: 23017669)
J Adv Pract Oncol. 2013 Jul;4(4):263-8. (PMID: 25032007)
Nat Rev Mater. 2018 May;3(5):21-37. (PMID: 31223488)
Adv Healthc Mater. 2016 May;5(9):1014-24. (PMID: 26924785)
Nat Rev Drug Discov. 2016 Nov;15(11):751-769. (PMID: 27616293)
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4861. (PMID: 23533270)
J Pathol. 2014 Sep;234(1):34-45. (PMID: 24797403)
Bioconjug Chem. 2017 Mar 15;28(3):846-856. (PMID: 28122451)
Oncotarget. 2017 Apr 4;8(14):22741-22758. (PMID: 28009986)
Nat Biotechnol. 2017 Jul;35(7):659-666. (PMID: 28562594)
Molecules. 2019 Feb 14;24(4):. (PMID: 30769788)
Cells. 2019 Aug 13;8(8):. (PMID: 31412684)
Int J Cancer. 2019 Jan 15;144(2):366-371. (PMID: 30151914)
Cell Death Discov. 2018 Feb 1;4:7. (PMID: 29531804)
Br J Cancer. 2006 Mar 27;94(6):798-805. (PMID: 16508637)
Trends Mol Med. 2017 May;23(5):393-410. (PMID: 28341301)
Oncotarget. 2017 Aug 5;8(40):66747-66757. (PMID: 28977993)
Nat Rev Clin Oncol. 2017 Sep;14(9):531-548. (PMID: 28252003)
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6235-40. (PMID: 21444794)
Sci Rep. 2016 Feb 03;6:20030. (PMID: 26837601)
Cancer. 2014 Jul 1;120(13):2006-15. (PMID: 24705963)
BMC Cancer. 2019 Nov 1;19(1):1030. (PMID: 31675944)
Cancer Discov. 2017 May;7(5):462-477. (PMID: 28331002)
Semin Oncol. 2016 Aug;43(4):464-75. (PMID: 27663478)
Mol Oncol. 2013 Apr;7(2):178-89. (PMID: 23465602)
Clin Cancer Res. 2006 Aug 1;12(15):4652-61. (PMID: 16899615)
J Clin Invest. 2010 Jul;120(7):2619-26. (PMID: 20516646)
CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
J Cancer Res Clin Oncol. 1991;117(6):515-8. (PMID: 1720783)
Adv Mater. 2016 Jan 27;28(4):677-84. (PMID: 26606883)
Nat Biotechnol. 2017 Jun;35(6):577-582. (PMID: 28459450)
Gastroenterology. 2013 Apr;144(4):705-17. (PMID: 23415801)
Ann Surg Treat Res. 2017 Oct;93(4):173-180. (PMID: 29094026)
Sci Rep. 2019 May 8;9(1):7103. (PMID: 31068603)
Nat Rev Genet. 2019 Jul;20(7):377-388. (PMID: 30737492)
Nat Protoc. 2016 Feb;11(2):302-15. (PMID: 26766116)
Oncotarget. 2016 May 3;7(18):25593-603. (PMID: 27016417)
Cancer Discov. 2011 Jul;1(2):108-16. (PMID: 22116793)
Mol Cancer Ther. 2011 Aug;10(8):1311-6. (PMID: 21673092)
Nat Rev Urol. 2013 Aug;10(8):483-7. (PMID: 23752995)
Cells. 2019 Oct 27;8(11):. (PMID: 31717887)
Cancer Biol Ther. 2009 Jul;8(14):1313-7. (PMID: 19502780)
Br J Cancer. 2015 Apr 14;112(8):1306-13. (PMID: 25867263)
Science. 2018 Feb 23;359(6378):920-926. (PMID: 29472484)
Sci Rep. 2018 Mar 6;8(1):4097. (PMID: 29511269)
معلومات مُعتمدة: 680209 International ERC_ European Research Council
فهرسة مساهمة: Keywords: 3D bioprinting; Colorectal cancer; cancer-on-chip; drug combination; organoids; patient-derived xenograft
تواريخ الأحداث: Date Created: 20200604 Latest Revision: 20200928
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7352800
DOI: 10.3390/cancers12061423
PMID: 32486365
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers12061423