دورية أكاديمية
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Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice.

التفاصيل البيبلوغرافية
العنوان: Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice.
المؤلفون: Mahmoudvand H; Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.; Department of Laboratory Sciences, School of Allied Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran., Tavakoli Kareshk A; Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran., Nabi Moradi M; Department of Laboratory Sciences, School of Allied Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran., Monzote Fidalgo L; Department of Parasitology, Institute of Tropical Medicine 'Pedro Kourí', La Lisa, Havana, Cuba., Mirbadie SR; School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Niazi M; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran., Khatami M; Bam University of Medical Sciences, Bam, Iran.
المصدر: Iranian journal of parasitology [Iran J Parasitol] 2020 Jan-Mar; Vol. 15 (1), pp. 22-30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Tehran University of Medical Sciences Country of Publication: Iran NLM ID: 101464309 Publication Model: Print Cited Medium: Print ISSN: 1735-7020 (Print) Linking ISSN: 17357020 NLM ISO Abbreviation: Iran J Parasitol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Tehran : Tehran University of Medical Sciences
مستخلص: Background: Broad spectrums of pharmacological properties, including antimicrobial activity have been attributed to Zataria multiflora Boiss (Laminaceae). The in vivo efficacy and safety of Z. multiflora essential oil (ZM-EO) were evaluated against acute toxoplasmosis caused by Toxoplasma gondii (Sarcocystidae) in mice.
Methods: Z. multiflora (aerial parts) was obtained from the rural districts of Kerman city (Kerman Province) Southwestern Iran, in May of 2016. Male NMRI mice were orally treated with normal saline (control group) and ZM-EO at the doses of 0.2 and 0.4 mL/kg once a day for 14 d (8 mice in each group) . On the 15 th day, the mice were infected with 104 tachyzoites of T. gondii RH strain by intraperitoneal route. The mortality rate and parasite load were determined in the infected mice. Additionally, 24 mice were applied to examine the sub-acute toxicity of ZM-EO at the above doses after treatment during 14 d.
Results: GC/MS analysis displayed that the key constituents were thymol (45.4%), carvacrol (23%) and p -cymene (10.6%), respectively. Overall, 100% mortality was observed on the 8 th and 9 th days in treated mice with the concentrations of 0.2 and 0.4 mL/kg, respectively. The mean number of tachyzoites in the mice treated with 0.2 and 0.4 mL/kg of ZM-EO were 189×10 4 and 76×10 4 cell/mL, respectively, meaningfully ( P <0.05) reduced compared with the control mice. Results also demonstrated that ZM-EO had no important toxicity on mice.
Conclusion: The results demonstrated the efficacy of ZM-EO against acute toxoplasmosis. Nevertheless, supplementary surveys are mandatory to examine its precise effects, mainly immunomodulatory effect on toxoplasmosis.
Competing Interests: Conflict of interests The authors declare that there is no conflict of interest in this study.
(Copyright© Iranian Society of Parasitology & Tehran University of Medical Sciences.)
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فهرسة مساهمة: Keywords: Essential oil; Herbal medicines; Prophylactic; Toxicity; Toxoplasma gondii; Treatment
تواريخ الأحداث: Date Created: 20200604 Latest Revision: 20220414
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7244848
PMID: 32489372
قاعدة البيانات: MEDLINE
الوصف
تدمد:1735-7020