دورية أكاديمية
Preimplantation interlead ECG heterogeneity is superior to QRS complex duration in predicting mechanical super-response in patients with non-left bundle branch block receiving cardiac resynchronization therapy.
| العنوان: | Preimplantation interlead ECG heterogeneity is superior to QRS complex duration in predicting mechanical super-response in patients with non-left bundle branch block receiving cardiac resynchronization therapy. |
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| المؤلفون: | Bortolotto AL; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Verrier RL; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address: rverrier@bidmc.harvard.edu., Nearing BD; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts., Marum AA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Araujo Silva B; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Pedreira GC; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Tessarolo Silva F; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Medeiros SA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Sroubek J; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts., Zimetbaum PJ; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts., Chang JD; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. |
| المصدر: | Heart rhythm [Heart Rhythm] 2020 Nov; Vol. 17 (11), pp. 1887-1896. Date of Electronic Publication: 2020 Jun 01. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, c2004- |
| مواضيع طبية MeSH: | Electrocardiography*, Bundle-Branch Block/*therapy , Cardiac Resynchronization Therapy/*methods , Heart Rate/*physiology , Stroke Volume/*physiology , Ventricular Function, Left/*physiology, Aged ; Bundle-Branch Block/physiopathology ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies |
| مستخلص: | Background: Reliable quantitative preimplantation predictors of response to cardiac resynchronization therapy (CRT) are needed. Objective: We tested the utility of preimplantation R-wave and T-wave heterogeneity (RWH and TWH, respectively) compared to standard QRS complex duration in identifying mechanical super-responders to CRT and mortality risk. Methods: We analyzed resting 12-lead electrocardiographic recordings from all 155 patients who received CRT devices between 2006 and 2018 at our institution and met class I and IIA American College of Cardiology/American Heart Association/Heart Rhythm Society guidelines with echocardiograms before and after implantation. Super-responders (n=35, 23%) had ≥20% increase in left ventricular ejection fraction and/or ≥20% decrease in left ventricular end-systolic diameter and were compared with non-super-responders (n=120, 77%), who did not meet these criteria. RWH and TWH were measured using second central moment analysis. Results: Among patients with non-left bundle branch block (LBBB), preimplantation RWH was significantly lower in super-responders than in non-super-responders in 3 of 4 lead sets (P=.001 to P=.038) and TWH in 2 lead sets (both, P=.05), with the corresponding areas under the curve (RWH: 0.810-0.891, P<.001; TWH: 0.759-0.810, P≤.005). No differences were observed in the LBBB group. Preimplantation QRS complex duration also did not differ between super-responders and non-super-responders among patients with (P=.856) or without (P=.724) LBBB; the areas under the curve were nonsignificant (both, P=.69). RWH Conclusion: Preimplantation interlead electrocardiographic heterogeneity but not QRS complex duration predicts mechanical super-response to CRT in patients with non-LBBB. (Copyright © 2020 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cardiac resynchronization therapy; Heart failure; Preimplantation; R-wave heterogeneity; Super-response; Survival; T-wave heterogeneity |
| تواريخ الأحداث: | Date Created: 20200605 Date Completed: 20210914 Latest Revision: 20210914 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.hrthm.2020.05.036 |
| PMID: | 32497764 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1556-3871 |
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| DOI: | 10.1016/j.hrthm.2020.05.036 |