دورية أكاديمية
Influence of an Exergaming Training Program on Reducing the Expression of IL-10 and TGF-β in Cancer Patients.
| العنوان: | Influence of an Exergaming Training Program on Reducing the Expression of IL-10 and TGF-β in Cancer Patients. |
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| المؤلفون: | da Silva Alves R; Bioscience Program, Federal University of Alfenas, Alfenas, Brazil.; Course of Physical Therapy, University of Sapucai Valley, Pouso Alegre, Brazil., Abdalla DR; Health Sciences, Humans Talents Faculty and University of Uberaba, Uberaba, Brazil., Iunes DH; Motricity Science Institute, and Federal University of Alfenas, Alfenas, Brazil.; Rehabilitation Science Program, Federal University of Alfenas, Alfenas, Brazil., Mariano KOP; Rehabilitation Science Program, Federal University of Alfenas, Alfenas, Brazil., Borges JBC; Motricity Science Institute, and Federal University of Alfenas, Alfenas, Brazil.; Rehabilitation Science Program, Federal University of Alfenas, Alfenas, Brazil., Murta EFC; Institute of Oncology Research, Federal University of Triângulo Mineiro, Uberaba, Brazil., Michelin MA; Institute of Oncology Research, Federal University of Triângulo Mineiro, Uberaba, Brazil., Carvalho LC; Bioscience Program, Federal University of Alfenas, Alfenas, Brazil.; Motricity Science Institute, and Federal University of Alfenas, Alfenas, Brazil.; Rehabilitation Science Program, Federal University of Alfenas, Alfenas, Brazil. |
| المصدر: | Games for health journal [Games Health J] 2020 Dec; Vol. 9 (6), pp. 446-452. Date of Electronic Publication: 2020 Jun 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101583709 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-7856 (Electronic) Linking ISSN: 2161783X NLM ISO Abbreviation: Games Health J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New Rochelle, N.Y. : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: | Exercise/*psychology , Interleukin-10/*analysis , Neoplasms/*genetics , TGF-beta Superfamily Proteins/*analysis , Video Games/*standards, Adult ; Aged ; Female ; Gene Expression/physiology ; Humans ; Interleukin-10/blood ; Male ; Middle Aged ; Neoplasms/therapy ; TGF-beta Superfamily Proteins/blood ; Video Games/psychology |
| مستخلص: | Objective: To evaluate the effect of exergaming in the plasma levels of adipokines (interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor-alpha [TNF-α]), Th1 (IL-2, IL-12, and interferon gamma [IFN-γ]), Th2 (IL-4 and IL-33), Th17 (IL-17 and IL-23), and regulatory T (Treg) (IL-10 and transforming growth factor-beta [TGF-β]) in cancer patients undergoing treatment. Materials and Methods: We conducted a quasi-experimental control clinical trial using exergaming in all groups through the Xbox 360 Kinect™. The game used in this study was called Your Shape Fitness Evolved 2012 . The volunteer participants played the game two to three times per week, for a total of 20 sessions. Forty-five volunteer participants were divided into 3 groups: cancer patients undergoing chemotherapy and/or radiotherapy treatment (chemotherapy and/or radiotherapy group CRG; n = 15); cancer patients who finished chemotherapy and/or radiotherapy treatment (cancer accompaniment group CAG; n = 15); and the control group (volunteers without a cancer diagnosis CG; n = 15). In the pre- and post-training period, all volunteers submitted to blood collection procedures using the enzyme-linked immunosorbent assay (ELISA). This test was used to obtain the levels of adipokines expression (IL-1β, IL-6, IL-8, and TNF-α) and the cytokine profiles Th1 (IL-2, IL-12, and IFN-γ), Th2 (IL-4 and IL-33), Th17 (IL-17 and IL-23), and Treg (IL-10 and TGF-β). Results: After exergaming, the CRG showed significant reductions in proinflammatory cytokines (IL-6: P < 0.05; IL-10: P = 0.038; TGF-β: P = 0.049) and for CAG (IL-10: P = 0.034), as well as a reduction in the expression of cytokines related to the action of T lymphocytes. Conclusion: Exergaming promoted changes in the expression of cytokine profiles IL-6, IL-10, and TGF-β, which correlated with the action profiles of CD4 + T lymphocytes. |
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| فهرسة مساهمة: | Keywords: Adipokines; Cancer; Cytokines; Exergaming; Rehabilitation |
| المشرفين على المادة: | 0 (IL10 protein, human) 0 (TGF-beta Superfamily Proteins) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20200606 Date Completed: 20210810 Latest Revision: 20211203 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7757568 |
| DOI: | 10.1089/g4h.2020.0022 |
| PMID: | 32498637 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2161-7856 |
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| DOI: | 10.1089/g4h.2020.0022 |