دورية أكاديمية
أعرض في EDS

Antidepressant-like effect of (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one in rats exposed to malathion: Involvement of BDNF-Trkβ pathway and AChE.

التفاصيل البيبلوغرافية
العنوان: Antidepressant-like effect of (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one in rats exposed to malathion: Involvement of BDNF-Trkβ pathway and AChE.
المؤلفون: Savall ASP; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., Fidelis EM; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., Angonesi V; Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil., Bresolin L; Federal University of Rio Grande - Campus Carreiros, Rio Grande 96201-900, RS, Brazil., Gervini VC; Federal University of Rio Grande - Campus Carreiros, Rio Grande 96201-900, RS, Brazil., Quines C; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., Puntel RL; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., Roos DH; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., de Ávila DS; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil., Pinton S; Federal University of Pampa - Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil. Electronic address: simonepinton@unipampa.edu.br.
المصدر: Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117892. Date of Electronic Publication: 2020 Jun 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
مواضيع طبية MeSH: Signal Transduction*/drug effects, Acetylcholinesterase/*metabolism , Antidepressive Agents/*pharmacology , Brain-Derived Neurotrophic Factor/*metabolism , Indoles/*pharmacology , Malathion/*toxicity , Oxindoles/*pharmacology , Receptor, trkB/*metabolism, Animals ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/chemistry ; Antidepressive Agents/therapeutic use ; Behavior, Animal/drug effects ; Depression/drug therapy ; Indoles/administration & dosage ; Indoles/chemistry ; Indoles/therapeutic use ; Male ; Motor Activity/drug effects ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxindoles/administration & dosage ; Oxindoles/chemistry ; Oxindoles/therapeutic use ; Rats, Wistar
مستخلص: Background: Organophosphorus pesticides exert their toxic effects mainly by the inhibition of acetylcholinesterase (AChE), which is related to emotional disorders, such as depression. Atropine-oximes therapy is commonly used; however, the efficacy of oximes in the reactivation of AChE has been inconsistent. The objective of this study was to investigate the possible neuroprotective effect of (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one (Cℓ-HIN), a compound that combines the isatin and oxime functional groups, in rats exposed to malathion. The effect of Cℓ-HIN on the AChE activity and the BDNF-Trkβ pathway in the prefrontal cortex of malathion-exposed rats were tested.
Methods: Wistar male rats were co-treated with Cℓ-HIN [50 mg/kg (p.o.) (3 mL/kg)] and/or malathion [250 mg/kg (i.p.) (5 mL/kg)] and performed behavioral tests twelve hours after these exposures.
Results: The Cℓ-HIN reversed the increased immobility time in the forced swimming test and the decreased grooming time in the splash test induced by malathion, but any significant difference was observed in locomotion analysis. These results demonstrate the antidepressant-like effect of Cℓ-HIN. The cortical AChE activity was reactivated by Cℓ-HIN in rats exposed to malathion. Malathion induced an increase in Trkβ and a decrease in BDNF levels in the prefrontal cortex of rats, which were avoided by Cℓ-HIN.
Conclusion: These findings support the hypothesis that Cℓ-HIN is an AChE reactivator with antidepressant-like properties, which is related to the improvement of BDNF-Trkβ signaling after acute exposure to malathion in rats. Thus, the results allow suggesting the potential use of Cℓ-HIN as an oxime-based therapy against the neurotoxic effects of malathion.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acetylcholinesterase; Isatin; Neurotrophic factor; Organophosphate; Oxime
المشرفين على المادة: 0 ((3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one)
0 (Antidepressive Agents)
0 (Brain-Derived Neurotrophic Factor)
0 (Indoles)
0 (Neuroprotective Agents)
0 (Oxindoles)
0 (indolin-2-one)
EC 2.7.10.1 (Ntrk2 protein, rat)
EC 2.7.10.1 (Receptor, trkB)
EC 3.1.1.7 (Acetylcholinesterase)
U5N7SU872W (Malathion)
تواريخ الأحداث: Date Created: 20200606 Date Completed: 20200831 Latest Revision: 20201109
رمز التحديث: 20240829
DOI: 10.1016/j.lfs.2020.117892
PMID: 32502538
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0631
DOI:10.1016/j.lfs.2020.117892