دورية أكاديمية
أعرض في EDS

Immune Suppression of Glia Maturation Factor Reverses Behavioral Impairment, Attenuates Amyloid Plaque Pathology and Neuroinflammation in an Alzheimer's Disease Mouse Model.

التفاصيل البيبلوغرافية
العنوان: Immune Suppression of Glia Maturation Factor Reverses Behavioral Impairment, Attenuates Amyloid Plaque Pathology and Neuroinflammation in an Alzheimer's Disease Mouse Model.
المؤلفون: Ahmed ME; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Selvakumar GP; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Thangavel R; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Kempuraj D; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Raikwar SP; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Zaheer S; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA., Iyer S; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA., Zaheer A; Department of Neurology and Center for Translational Neuroscience, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA. zaheera@health.missouri.edu.; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA. zaheera@health.missouri.edu.
المصدر: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2021 Jun; Vol. 16 (2), pp. 363-375. Date of Electronic Publication: 2020 Jun 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Springer Science + Business Media, c2006-
مواضيع طبية MeSH: Alzheimer Disease/*pathology , Brain/*pathology , Glia Maturation Factor/*antagonists & inhibitors , Plaque, Amyloid/*pathology, Animals ; Behavior, Animal ; Disease Models, Animal ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Degeneration/pathology
مستخلص: Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disorder recognized by accumulation of amyloid-plaques (APs) and neurofibrillary tangles (NFTs) and eventually loss of memory. Glia maturation factor (GMF), a neuroinflammatory protein first time isolated and cloned in our laboratory plays an important role in the pathogenesis of AD. However, no studies have been reported on whether anti-GMF antibody administration could downregulate neuroinflammation and attenuate amyloid pathology in AD brain. We investigated the potential effect of single dose of (2 mg/kg b.wt/mouse) intravenously (iv) injected with anti-GMF antibodyon cognitive function, neuroprotection, neuroinflammation and Aβ load in the brain of 9-month-old 5XFAD mice. Following 4 weeks of anti-GMF antibody delivery in mice, we found reduced expression of GMF, astrocytic glial fibrillary acidic protein (GFAP) and microglial ionizing calcium binding adaptor molecule 1 (Iba1) as well as improvement inneuroinflammatory response via inhibition of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) production and amyloid pathology in the cerebral cortex and hippocampal CA1 region of 5XFAD mice. Correspondingly, blockade of GMF function with anti-GMF antibody improved spatial learning, memory, and long-term recognition memory in 5XFAD mice. The present study demonstrates that the immune checkpoint blockade of GMF function with anti-GMF antibody coordinates anti-inflammatory effects to attenuate neurodegeneration in the cortex and hippocampal CA1 region of 5XFAD mouse brain. Further, our data suggest, that pharmacological immune neutralization of GMF is a promising neuroprotective strategy totherapeutically target neuroinflammation and neurodegeneration in AD. Graphical Abstract 5XFAD mice Polyclonal anti-GMF antibody.
References: Neurochem Res. 2013 Aug;38(8):1580-9. (PMID: 23640177)
Nat Commun. 2015 Jan 29;6:6176. (PMID: 25630253)
Behav Brain Res. 2010 Dec 25;214(2):254-9. (PMID: 20553765)
J Biol Chem. 2006 Feb 17;281(7):4292-9. (PMID: 16361260)
Brain Res. 2011 Jan 12;1368:336-45. (PMID: 20974113)
Neurobiol Aging. 2017 Jan;49:165-182. (PMID: 27815990)
Neuroscience. 2016 Nov 12;336:39-48. (PMID: 27590267)
Behav Brain Res. 1988 Nov 1;31(1):47-59. (PMID: 3228475)
J Neuroimmune Pharmacol. 2013 Jun;8(3):643-50. (PMID: 23397250)
J Neurochem. 1991 Aug;57(2):483-90. (PMID: 1712830)
CNS Neurol Disord Drug Targets. 2009 Mar;8(1):7-15. (PMID: 19275633)
Exp Brain Res. 1994;100(1):85-92. (PMID: 7813656)
Nat Commun. 2013;4:1562. (PMID: 23463005)
Arkh Anat Gistol Embriol. 1981 Dec;81(12):39-45. (PMID: 9103177)
Mol Neurobiol. 2018 Sep;55(9):7132-7152. (PMID: 29383690)
Neurobiol Aging. 2009 Feb;30(2):198-209. (PMID: 17658666)
Neurobiol Aging. 2007 Apr;28(4):533-6. (PMID: 16569464)
Front Aging Neurosci. 2017 May 18;9:150. (PMID: 28572767)
Neurobiol Aging. 2000 May-Jun;21(3):383-421. (PMID: 10858586)
Front Aging Neurosci. 2016 Dec 20;8:310. (PMID: 28066234)
Acta Neuropathol. 2013 Oct;126(4):461-77. (PMID: 24224195)
J Neuroimmunol. 2002 May;126(1-2):50-7. (PMID: 12020956)
J Neurochem. 2010 Mar;112(5):1099-114. (PMID: 20002526)
J Invest Dermatol. 2013 Sep;133(9):e12. (PMID: 23949770)
Brain Res. 2008 May 7;1208:192-203. (PMID: 18395194)
Nat Neurosci. 2009 Nov;12(11):1361-3. (PMID: 19838177)
J Alzheimers Dis. 2017;60(3):1143-1160. (PMID: 28984607)
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14515-20. (PMID: 15452348)
Nat Neurosci. 2002 May;5(5):452-7. (PMID: 11941374)
Int J Dev Neurosci. 2006 Apr-May;24(2-3):167-76. (PMID: 16472958)
J Neurosci. 2019 Apr 10;39(15):2792-2809. (PMID: 30728170)
J Neurosci Res. 2006 Feb 15;83(3):374-84. (PMID: 16385556)
Science. 1992 Apr 10;256(5054):184-5. (PMID: 1566067)
MedGenMed. 2006 Apr 26;8(2):25. (PMID: 16926764)
J Mol Neurosci. 2017 Jan;61(1):42-51. (PMID: 27604243)
Nature. 2010 Nov 11;468(7321):232-43. (PMID: 21068832)
BMC Neurosci. 2010 Oct 14;11:130. (PMID: 20946660)
Nat Clin Pract Neurol. 2006 Dec;2(12):679-89. (PMID: 17117171)
Glia. 2007 Sep;55(12):1251-62. (PMID: 17659524)
Proc Natl Acad Sci U S A. 1989 May;86(10):3901-5. (PMID: 2726756)
Mol Med Today. 2000 Oct;6(10):392-7. (PMID: 11006528)
Lancet Neurol. 2015 Apr;14(4):388-405. (PMID: 25792098)
J Neurochem. 1993 Mar;60(3):914-20. (PMID: 8436977)
Nat Commun. 2014 Nov 19;5:5422. (PMID: 25406732)
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5. (PMID: 11438712)
J Neurosci. 2008 Aug 13;28(33):8354-60. (PMID: 18701698)
J Alzheimers Dis. 2018;61(2):553-560. (PMID: 29172001)
J Exp Med. 2015 Mar 9;212(3):287-95. (PMID: 25732305)
J Comp Physiol Psychol. 1979 Feb;93(1):74-104. (PMID: 221551)
J Neurosci. 2006 Oct 4;26(40):10129-40. (PMID: 17021169)
Mol Neurodegener. 2014 Jun 03;9:20. (PMID: 24893973)
Prog Neurobiol. 1998 Feb;54(3):289-311. (PMID: 9481800)
Cogn Process. 2012 May;13(2):93-110. (PMID: 22160349)
FASEB J. 1990 Dec;4(15):3360-3. (PMID: 2253851)
Eur J Neurosci. 2005 Dec;22(11):2827-32. (PMID: 16324117)
Neurochem Res. 2007 Dec;32(12):2123-31. (PMID: 17551829)
Nat Neurosci. 2011 Sep 27;14(10):1227-35. (PMID: 21952260)
Neurobiol Dis. 2009 Apr;34(1):163-77. (PMID: 19320056)
Behav Processes. 2008 Jul;78(3):481-6. (PMID: 18358637)
Mol Neurodegener. 2013 Jan 14;8:2. (PMID: 23316765)
معلومات مُعتمدة: R01 AG048205 United States AG NIA NIH HHS; AG048205 United States AG NIA NIH HHS; VA Research Career Scientist Award U.S. Department of Veterans Affairs; AG048205 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer’s disease; Amyloid pathology; Anti-GMF antibody; Cognition; Neuroinflammation
المشرفين على المادة: 0 (Glia Maturation Factor)
تواريخ الأحداث: Date Created: 20200607 Date Completed: 20211206 Latest Revision: 20211214
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8240471
DOI: 10.1007/s11481-020-09929-4
PMID: 32504312
قاعدة البيانات: MEDLINE
الوصف
تدمد:1557-1904
DOI:10.1007/s11481-020-09929-4