دورية أكاديمية
أعرض في EDS

Uterine smooth muscle tumours of uncertain malignant potential: single-centre experience and review of the literature.

التفاصيل البيبلوغرافية
العنوان: Uterine smooth muscle tumours of uncertain malignant potential: single-centre experience and review of the literature.
المؤلفون: Yordanov AD; Department of Gynaecological Oncology, Medical University of Pleven, Pleven, Bulgaria., Tantchev L; Obstetrics and Gynaecology Clinic, Acibadem City Clinic Hospital 'Tokuda', Sofia, Bulgaria., Vasileva P; Department of Obstetrics and Gynaecology, Medical University of Pleven, Pleven, Bulgaria., Strashilov S; Department of Plastic Restorative, Reconstructive, and Aesthetic Surgery, Medical University of Pleven, Pleven, Bulgaria., Vasileva-Slaveva M; EXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Austria.; Tyrolean Cancer Research Institute, Innsbruck, Austria.; EORTC Pathobiology Group, Brussels, Belgium., Konsoulova A; Department of Medical Oncology, Complex Oncological Centre Burgas, Burgas, Bulgaria.
المصدر: Przeglad menopauzalny = Menopause review [Prz Menopauzalny] 2020 Mar; Vol. 19 (1), pp. 30-34. Date of Electronic Publication: 2020 Apr 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Termedia Country of Publication: Poland NLM ID: 101263235 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1643-8876 (Print) Linking ISSN: 16438876 NLM ISO Abbreviation: Prz Menopauzalny Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Poznań : Termedia
مستخلص: Introduction: Uterine smooth muscle tumours of uncertain malignant potential (STUMPs) are a rare histologically heterogeneous group of uterine smooth muscle tumours (SMTs). Their malignant potential and clinical differentiation between leiomyoma and leiomyosarcoma remain uncertain prior to surgical removal.
Aim of the Study: To investigate the patients and tumour characteristics of patients with STUMPs and to propose algorithms for optimal diagnosis, treatment, and follow-up management.
Material and Methods: This was a single-centre retrospective cohort study of all patients who underwent surgery for a preoperative diagnosis of uterine myoma at the University Hospital "Dr. Georgi Stranski", Pleven, Bulgaria during a period of 33 months (from January 2013 until October 2015). Data were obtained from the medical history records. We performed descriptive analysis to characterise the patient population (e.g. demographics, age, contraceptive use, and complaints that led to the diagnosis) and the tumour characteristics. Last data were obtained prior May 2019.
Results: A total of 320 medical records were retrospectively evaluated. The preoperative diagnosis of myoma was confirmed in 279 of the cases (89.4%). In 27 (8.3%) cases the final histological result was completely different. In 14 (2.3%) a histological postoperative diagnosis of STUMP was identified. All 14 STUMP lesions were intramural with a median size of 7.5 cm (range 3.5 to 15 cm). The median age at diagnosis of STUMP was 45.4 years (range 36 to 52 years), and 92.9% ( n = 13) of the patients were premenopausal. Ultrasound data of a rapidly growing myoma were a reason for diagnosis in only three patients (25%), whereas 92.9% of the patients ( n = 13) presented with heavy menstrual bleeding with or without anaemia. After surgery, none of the patients with STUMP experienced a relapse of the disease within the median follow-up time of 48 months ( R = 40-78).
Conclusions: STUMP tumours are rare tumours, predominantly diagnosed in premenopausal women. They define a group of patients with very good long-term prognosis. Therefore, longer follow-up is needed to allow for conclusions on recurrence rate and survival.
(Copyright © 2020 Termedia.)
References: Am J Surg Pathol. 2008 Jan;32(1):98-102. (PMID: 18162776)
J Minim Invasive Gynecol. 2015 May-Jun;22(4):601-6. (PMID: 25596464)
Am J Obstet Gynecol. 2014 Apr;210(4):368.e1-368.e8. (PMID: 24368137)
Am J Surg Pathol. 2013 May;37(5):643-9. (PMID: 23552381)
J Minim Invasive Gynecol. 2012 May-Jun;19(3):288-95. (PMID: 22546421)
Ann Acad Med Singapore. 2010 Aug;39(8):625-8. (PMID: 20838704)
Int J Gynecol Pathol. 2008 Jan;27(1):68-73. (PMID: 18156978)
Oncol Lett. 2016 Feb;11(2):1425-1428. (PMID: 26893755)
Indian J Pathol Microbiol. 2016 Jul-Sep;59(3):301-4. (PMID: 27510664)
World J Oncol. 2017 Jun;8(3):76-80. (PMID: 29147439)
Am J Surg Pathol. 1994 Jun;18(6):535-58. (PMID: 8179071)
J Med Case Rep. 2016 Jan 22;10:22. (PMID: 26801982)
J Gynecol Oncol. 2012 Jan;23(1):69-71. (PMID: 22355470)
Prz Menopauzalny. 2019 Jun;18(2):123-125. (PMID: 31485209)
Gynecol Oncol. 2004 Sep;94(3):818-20. (PMID: 15350379)
Ultrasound Obstet Gynecol. 2015 Sep;46(3):284-98. (PMID: 25652685)
Int J Clin Exp Pathol. 2014 Oct 15;7(11):8136-42. (PMID: 25550862)
Int J Gynecol Cancer. 2016 Jan;26(1):149-55. (PMID: 26332395)
Cancer. 2014 Oct 15;120(20):3165-77. (PMID: 24986214)
Am J Surg Pathol. 2009 Jul;33(7):992-1005. (PMID: 19417585)
Adv Anat Pathol. 2010 Mar;17(2):91-112. (PMID: 20179432)
Eur J Gynaecol Oncol. 2016;37(3):367-73. (PMID: 27352566)
Expert Rev Anticancer Ther. 2016 Nov;16(11):1155-1166. (PMID: 27602604)
Obstet Gynecol. 1994 Jun;83(6):1015-20. (PMID: 8190416)
Fertil Steril. 1998 Sep;70(3):580-7. (PMID: 9757898)
Gynecol Oncol Rep. 2015 Aug 07;15:1-3. (PMID: 26937476)
Indian J Pathol Microbiol. 2011 Oct-Dec;54(4):706-11. (PMID: 22234095)
Gynecol Oncol. 2010 Jan;116(1):131-9. (PMID: 19853898)
Gynecol Oncol. 2009 Jun;113(3):324-6. (PMID: 19342083)
Ann Thorac Surg. 2016 Jan;101(1):253-8. (PMID: 26321441)
فهرسة مساهمة: Keywords: leiomyosarcoma; myoma; operative treatment; smooth muscle tumours with uncertain malignant potential
تواريخ الأحداث: Date Created: 20200609 Latest Revision: 20220414
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7258368
DOI: 10.5114/pm.2020.95333
PMID: 32508554
قاعدة البيانات: MEDLINE
الوصف
تدمد:1643-8876
DOI:10.5114/pm.2020.95333