Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections.

التفاصيل البيبلوغرافية
العنوان: Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections.
المؤلفون: Lv H; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Tsang OT; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong., Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Perera RAPM; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Leung WS; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong., So RTY; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Chan JMC; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong., Yip GK; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Chik TSH; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong., Wang Y; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Choi CYC; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong., Lin Y; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Ng WW; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Poon LLM; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Peiris JSM; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Mok CKP; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2020 Mar 17. Date of Electronic Publication: 2020 Mar 17.
نوع المنشور: Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: The World Health Organization has recently declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, as pandemic. There is currently a lack of knowledge in the antibody response elicited from SARS-CoV-2 infection. One major immunological question is concerning the antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by using plasma from patients infected by SARS-CoV-2 or SARS-CoV, and plasma obtained from infected or immunized mice. Our results show that while cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses is rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike. Whether these non-neutralizing antibody responses will lead to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding the antigenicity differences between SARS-CoV-2 and SARS-CoV, but also has important implications in vaccine.
Competing Interests: Competing interests The authors declare no competing interests.
التعليقات: Update in: Cell Rep. 2020 Jun 2;31(9):107725. (PMID: 32426212)
معلومات مُعتمدة: HHSN272201400006C United States AI NIAID NIH HHS; K99 AI139445 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20200609 Latest Revision: 20231019
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7239046
DOI: 10.1101/2020.03.15.993097
PMID: 32511317
قاعدة البيانات: MEDLINE
الوصف
DOI:10.1101/2020.03.15.993097