دورية أكاديمية
Hemagglutinin Structure and Activities.
| العنوان: | Hemagglutinin Structure and Activities. |
|---|---|
| المؤلفون: | Gamblin SJ; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom., Vachieri SG; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom., Xiong X; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom., Zhang J; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom., Martin SR; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom., Skehel JJ; Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom. |
| المصدر: | Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2021 Oct 01; Vol. 11 (10). Date of Electronic Publication: 2021 Oct 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Woodbury, NY : Cold Spring Harbor Laboratory Press, c2011- |
| مواضيع طبية MeSH: | Hemagglutinins/*immunology , Orthomyxoviridae/*immunology, Hemagglutinins/physiology ; Humans ; Hydrogen-Ion Concentration ; Membrane Fusion/immunology |
| مستخلص: | Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred into endosomes where membrane fusion by HAs is activated at pH between 5 and 6.5, depending on the strain of virus. Fusion activity requires extensive rearrangements in HA conformation that include extrusion of a buried "fusion peptide" to connect with the endosomal membrane, form a bridge to the virus membrane, and eventually bring both membranes close together. In this review, we give an overview of the structures of the 16 genetically and antigenically distinct subtypes of influenza A HA in relation to these two functions in virus replication and in relation to recognition of HA by antibodies that neutralize infection. (Copyright © 2021 Cold Spring Harbor Laboratory Press; all rights reserved.) |
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| معلومات مُعتمدة: | G0600522 United Kingdom MRC_ Medical Research Council; MC_U117584222 United Kingdom MRC_ Medical Research Council |
| المشرفين على المادة: | 0 (Hemagglutinins) |
| تواريخ الأحداث: | Date Created: 20200610 Date Completed: 20211213 Latest Revision: 20231002 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8485738 |
| DOI: | 10.1101/cshperspect.a038638 |
| PMID: | 32513673 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2157-1422 |
|---|---|
| DOI: | 10.1101/cshperspect.a038638 |