دورية أكاديمية
أعرض في EDS

Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

التفاصيل البيبلوغرافية
العنوان: Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.
المؤلفون: Baldini F; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Hertel J; School of Medicine, National University of Ireland, Galway, Ireland.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Sandt E; Integrated BioBank of Luxembourg, Dudelange, Luxembourg., Thinnes CC; School of Medicine, National University of Ireland, Galway, Ireland., Neuberger-Castillo L; Integrated BioBank of Luxembourg, Dudelange, Luxembourg., Pavelka L; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg (CHL), Luxembourg City, Luxembourg., Betsou F; Integrated BioBank of Luxembourg, Dudelange, Luxembourg., Krüger R; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg (CHL), Luxembourg City, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Strassen, Luxembourg., Thiele I; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg. ines.thiele@nuigalway.ie.; School of Medicine, National University of Ireland, Galway, Ireland. ines.thiele@nuigalway.ie.; Discipline of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland. ines.thiele@nuigalway.ie.; APC Microbiome, Cork, Ireland. ines.thiele@nuigalway.ie.
مؤلفون مشاركون: NCER-PD Consortium
المصدر: BMC biology [BMC Biol] 2020 Jun 09; Vol. 18 (1), pp. 62. Date of Electronic Publication: 2020 Jun 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007 (Electronic) Linking ISSN: 17417007 NLM ISO Abbreviation: BMC Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2003-
مواضيع طبية MeSH: Gastrointestinal Microbiome/*physiology , Parkinson Disease/*metabolism, Aged ; Case-Control Studies ; Female ; Humans ; Luxembourg ; Male ; Middle Aged ; Parkinson Disease/microbiology ; RNA, Bacterial/analysis ; RNA, Ribosomal, 16S/analysis
مستخلص: Background: Parkinson's disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson's Study (n = 147 typical PD cases, n = 162 controls).
Results: All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed by self-reporting questionnaires. Stool samples from these individuals were first analysed by 16S rRNA gene sequencing. Second, we predicted the potential secretion for 129 microbial metabolites through personalised metabolic modelling using the microbiome data and genome-scale metabolic reconstructions of human gut microbes. Our key results include the following. Eight genera and seven species changed significantly in their relative abundances between PD patients and healthy controls. PD-associated microbial patterns statistically depended on sex, age, BMI, and constipation. Particularly, the relative abundances of Bilophila and Paraprevotella were significantly associated with the Hoehn and Yahr staging after controlling for the disease duration. Furthermore, personalised metabolic modelling of the gut microbiomes revealed PD-associated metabolic patterns in the predicted secretion potential of nine microbial metabolites in PD, including increased methionine and cysteinylglycine. The predicted microbial pantothenic acid production potential was linked to the presence of specific non-motor symptoms.
Conclusion: Our results suggest that PD-associated alterations of the gut microbiome can translate into substantial functional differences affecting host metabolism and disease phenotype.
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معلومات مُعتمدة: 692320 International Horizon 2020 Framework Programme; 757922 International Horizon 2020 Framework Programme; MR/L023784/1 United Kingdom MRC_ Medical Research Council; J-0901 United Kingdom PUK_ Parkinson's UK; FNR/P13/6682797 International Fonds National de la Recherche Luxembourg; MR/M024962/1 United Kingdom MRC_ Medical Research Council; MC_EX_MR/N50192X/1 United Kingdom MRC_ Medical Research Council; NCER13/BM/11264123 International Fonds National de la Recherche Luxembourg (LU)
فهرسة مساهمة: Investigator: G Aguayo; D Allen; W Ammerlann; M Aurich; R Balling; P Banda; K Beaumont; R Becker; D Berg; S Binck; A Bisdorff; D Bobbili; K Brockmann; J Calmes; L Castillo; N Diederich; R Dondelinger; D Esteves; JY Ferrand; R Fleming; M Gantenbein; T Gasser; P Gawron; L Geffers; V Giarmana; E Glaab; CPC Gomes; N Goncharenko; J Graas; M Graziano; V Groues; A Grünewald; W Gu; G Hammot; AM Hanff; L Hansen; M Hansen; H Haraldsdöttir; L Heirendt; S Herbrink; S Herzinger; M Heymann; K Hiller; G Hipp; M Hu; L Huiart; A Hundt; N Jacoby; J Jarosław; Y Jaroz; P Kolber; J Kutzera; Z Landoulsi; C Larue; R Lentz; I Liepelt; R Liszka; L Longhino; V Lorentz; C Mackay; W Maetzler; K Marcus; G Marques; J Martens; C Mathay; P Matyjaszczyk; P May; F Meisch; M Menster; M Minelli; M Mittelbronn; B Mollenhauer; K Mommaerts; C Moreno; F Mühlschlegel; R Nati; U Nehrbass; S Nickels; B Nicolai; JP Nicolay; A Noronha; W Oertel; M Ostaszewski; S Pachchek; C Pauly; M Perquin; D Reiter; I Rosety; K Rump; V Satagopam; M Schlesser; S Schmitz; S Schmitz; R Schneider; J Schwamborn; A Schweicher; J Simons; L Stute; C Trefois; JP Trezzi; M Vaillant; D Vasco; M Vyas; R Wade-Martins; P Wilmes
Keywords: Computational modelling; Gut microbiome; Metabolic modelling; Parkinson’s disease; Transsulfuration pathway
المشرفين على المادة: 0 (RNA, Bacterial)
0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20200611 Date Completed: 20210607 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7285525
DOI: 10.1186/s12915-020-00775-7
PMID: 32517799
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7007
DOI:10.1186/s12915-020-00775-7