دورية أكاديمية
Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy.
| العنوان: | Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy. |
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| المؤلفون: | Frey B; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Bavaria, Germany., Mika J; Department of Data Science and Engineering, Silesian University of Technology, 44-100, Gliwice, Poland., Jelonek K; Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102, Gliwice, Poland., Cruz-Garcia L; Centre for Radiation, Chemical and Environmental Hazards, Cancers Mechanisms and Biomarkers group, Public Health England, Chilton, OX11 ORQ, Didcot, Oxfordshire, UK., Roelants C; Inovarion, 75005, Paris, France., Testard I; Univ. Grenoble Alpes, CEA, CNRS, IRIG-LCBM-UMR5249, 38054, Grenoble, France., Cherradi N; Univ. Grenoble Alpes, INSERM, CEA, IRIG-BCI-UMR_S1036, 38054, Grenoble, France., Lumniczky K; National Public Health Center, 1097, Budapest, Hungary., Polozov S; Centre for Radiation, Chemical and Environmental Hazards, Cancers Mechanisms and Biomarkers group, Public Health England, Chilton, OX11 ORQ, Didcot, Oxfordshire, UK.; HQ Science Limited, 5 The Quay, PE27 5AR, St. Ives, Cambridgeshire, United Kingdom., Napieralska A; Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102, Gliwice, Poland., Widlak P; Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102, Gliwice, Poland., Gaipl US; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Bavaria, Germany., Badie C; Centre for Radiation, Chemical and Environmental Hazards, Cancers Mechanisms and Biomarkers group, Public Health England, Chilton, OX11 ORQ, Didcot, Oxfordshire, UK., Polanska J; Department of Data Science and Engineering, Silesian University of Technology, 44-100, Gliwice, Poland., Candéias SM; Univ. Grenoble Alpes, CEA, CNRS, IRIG-LCBM-UMR5249, 38054, Grenoble, France. serge.candeias@cea.fr. |
| المصدر: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2020 Nov; Vol. 196 (11), pp. 1018-1033. Date of Electronic Publication: 2020 Jun 09. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Urban & Vogel Country of Publication: Germany NLM ID: 8603469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-099X (Electronic) Linking ISSN: 01797158 NLM ISO Abbreviation: Strahlenther Onkol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [München] : Urban & Vogel, [c1986- |
| مواضيع طبية MeSH: | Adenocarcinoma/*radiotherapy , Adenocarcinoma/*surgery , Immune System/*radiation effects , Metabolome/*radiation effects , Neoplasm Proteins/*blood , Prostatic Neoplasms/*radiotherapy , Prostatic Neoplasms/*surgery , Proteome/*radiation effects , Radiosurgery/*methods , Radiotherapy, Intensity-Modulated/*methods , Stress, Physiological/*radiation effects, Adenocarcinoma/immunology ; Adenocarcinoma/physiopathology ; Aged ; Aged, 80 and over ; Biomarkers ; Cytokines/blood ; Gene Expression Regulation, Neoplastic/radiation effects ; HLA Antigens/blood ; Humans ; Inflammation Mediators/blood ; Lysophosphatidylcholines/blood ; Male ; Middle Aged ; Monocytes/immunology ; Phosphatidylcholines/blood ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/physiopathology |
| مستخلص: | Background: In this exploratory study, the impact of local irradiation on systemic changes in stress and immune parameters was investigated in eight patients treated with intensity-modulated radiation therapy (IMRT) or stereotactic ablative body radiotherapy (SABR) for prostate adenocarcinoma to gain deeper insights into how radiotherapy (RT) modulates the immune system. Patients and Methods: RT-qPCR, flow cytometry, metabolomics, and antibody arrays were used to monitor a panel of stress- and immune-related parameters before RT, after the first fraction (SABR) or the first week of treatment (IMRT), after the last fraction, and 3 weeks later in the blood of IMRT (N = 4) or SABR (N = 4) patients. Effect size analysis was used for comparison of results at different timepoints. Results: Several parameters were found to be differentially modulated in IMRT and SABR patients: the expression of TGFB1, IL1B, and CCL3 genes; the expression of HLA-DR on circulating monocytes; the abundance and ratio of phosphatidylcholine and lysophosphatidylcholine metabolites in plasma. More immune modulators in plasma were modulated during IMRT than SABR, with only two common proteins, namely GDF-15 and Tim‑3. Conclusion: Locally delivered RT induces systemic modulation of the immune system in prostate adenocarcinoma patients. IMRT and SABR appear to specifically affect distinct immune components. |
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| فهرسة مساهمة: | Keywords: Biomarkers of radiation exposure; Immunophenotyping; Ionizing radiation; Prostate cancer; Systemic immune modulation |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cytokines) 0 (HLA Antigens) 0 (Inflammation Mediators) 0 (Lysophosphatidylcholines) 0 (Neoplasm Proteins) 0 (Phosphatidylcholines) 0 (Proteome) |
| تواريخ الأحداث: | Date Created: 20200611 Date Completed: 20201214 Latest Revision: 20201214 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7581573 |
| DOI: | 10.1007/s00066-020-01637-5 |
| PMID: | 32519025 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1439-099X |
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| DOI: | 10.1007/s00066-020-01637-5 |