دورية أكاديمية
Hypolipidemic and anti-inflammatory properties of phenolic rich Butia odorata fruit extract: potential involvement of paraoxonase activity.
| العنوان: | Hypolipidemic and anti-inflammatory properties of phenolic rich Butia odorata fruit extract: potential involvement of paraoxonase activity. |
|---|---|
| المؤلفون: | Ramos VP; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., da Silva PG; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Oliveira PS; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Bona NP; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Soares MSP; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Cardoso JS; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Hoffmann JF; Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos, Departamento de Ciência e Tecnologia Agroindustrial, Universidade Federal de Pelotas, Pelotas, Brazil., Chaves FC; Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos, Departamento de Ciência e Tecnologia Agroindustrial, Universidade Federal de Pelotas, Pelotas, Brazil., Schneider A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil., Spanevello RM; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Lencina CL; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Stefanello FM; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Tavares RG; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil. |
| المصدر: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2020 Jul; Vol. 25 (5), pp. 417-424. Date of Electronic Publication: 2020 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tayor & Francis Country of Publication: England NLM ID: 9606000 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5804 (Electronic) Linking ISSN: 1354750X NLM ISO Abbreviation: Biomarkers Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Tayor & Francis Original Publication: London : Taylor & Francis, c1996- |
| مواضيع طبية MeSH: | Arecaceae/*chemistry , Aryldialkylphosphatase/*genetics , Liver/*drug effects , Oxidative Stress/*drug effects, Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; C-Reactive Protein/metabolism ; Cholesterol, HDL/blood ; Chromatography, Liquid ; Fruit/chemistry ; Humans ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/pharmacology ; Male ; Phenols/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Tandem Mass Spectrometry ; Triglycerides/blood |
| مستخلص: | Aim: This study investigated the effects of polar Butia odorata fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol. Methods: Animals were divided into 3 groups: saline, saline plus tyloxapol, and B. odorata extract plus tyloxapol. Animals were treated for 15 days with a saline solution or B. odorata fruit extract and after hyperlipidaemia was induced by tyloxapol. Results: Treatment with B. odorata extract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher in B. odorata extract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present in B. odorata fruit extract were identified and quantified by LC-MS/MS. Conclusion: These findings indicated that phenolic rich B. odorata extract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats. |
| فهرسة مساهمة: | Keywords: Phenolic compounds; animal model system; cardiovascular disease |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Cholesterol, HDL) 0 (Hypolipidemic Agents) 0 (Phenols) 0 (Plant Extracts) 0 (Triglycerides) 9007-41-4 (C-Reactive Protein) EC 3.1.8.1 (Aryldialkylphosphatase) |
| تواريخ الأحداث: | Date Created: 20200611 Date Completed: 20210414 Latest Revision: 20210414 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/1354750X.2020.1781261 |
| PMID: | 32519899 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1366-5804 |
|---|---|
| DOI: | 10.1080/1354750X.2020.1781261 |