دورية أكاديمية
Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas.
| العنوان: | Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas. |
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| المؤلفون: | Lee HE; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Luo L; Good Clinical Practice Center, Guizhou Province People's Hospital, Guiyang, China.; Epidemiology-Cancer Research, Mayo Clinic, Rochester, MN 55905, USA., Kroneman T; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Passow MR; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Del Rosario KM; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Christensen MR; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Francis ME; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., O'Shaughnessy JW; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA., Blahnik AJ; Pathology Research Core, Mayo Clinic, Rochester, MN 55905, USA., Yang P; Epidemiology-Cancer Research, Mayo Clinic, Rochester, MN 55905, USA., Yi ES; Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA. |
| المصدر: | Journal of clinical & cellular immunology [J Clin Cell Immunol] 2020; Vol. 11 (1). Date of Electronic Publication: 2020 Jan 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: OMICS Publishing Group Country of Publication: United States NLM ID: 101563152 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2155-9899 (Print) NLM ISO Abbreviation: J Clin Cell Immunol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Sunnyvale, CA : OMICS Publishing Group |
| مستخلص: | Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3 + T-cells, CD20 + B-cells, and MUM1 + plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells and B-cells were correlated with patient's overall survival (OS) using Cox proportional hazards analysis. Results: Median age of patients was 69 years (range, 46-91 years) and 52 were male. Median numbers (interquartile range) of CD20 + B-cells per 1mm 2 of tumor area (IE plus ST) and IE compartment within tumor area were 590 (224-1276) and 101 (38-109), respectively; the corresponding numbers of MUM1 + plasma cells were 298 (180-605), and 67 (22-145), respectively. The proportion of MUM1 + plasma cell among all TILs (MUM1 + cells/[CD3 + cells +CD20 + cells+MUM1 + cells] × 100) ranged 1%-59% (median13%) in the tumor area and showed a significant association with OS by univariate Cox analysis (negative correlation with hazard ratio (HR)=12.50 [95% confidence interval (CI), 1.75-89.27]). There was a significant association between IE CD20 + B-cells and the patient's OS in univariate analysis (positive correlation with HR=0.81 [95% CI, 0.68-0.96]). Both parameters remained significant by multivariate analysis. Conclusion: High plasma cell % among TILs in the tumor area and low IE B-cell count were associated with worse prognosis in lung adenocarcinoma patients. Competing Interests: Disclosure The authors have no conflicts of interest to disclose. |
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| معلومات مُعتمدة: | R01 CA084354 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Adenocarcinoma; Plasma cells; Survival; Tumor-infiltrating immune cells; Tumor-infiltrating lymphocytes |
| تواريخ الأحداث: | Date Created: 20200612 Latest Revision: 20220415 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7286600 |
| PMID: | 32523798 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2155-9899 |
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