دورية أكاديمية
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability.
العنوان: | Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability. |
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المؤلفون: | McDermott JE; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97201, USA.; These authors contributed equally., Arshad OA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.; These authors contributed equally., Petyuk VA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Fu Y; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA., Gritsenko MA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Clauss TR; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Moore RJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Schepmoes AA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Zhao R; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Monroe ME; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Schnaubelt M; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA., Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Payne SH; Department of Biology, Brigham Young University, Provo, UT 84602, USA., Huang C; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Wang LB; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA., Foltz S; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA., Wyczalkowski M; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA., Wu Y; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA., Song E; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Brewer MA; Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT 06030, USA., Thiagarajan M; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Kinsinger CR; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA., Robles AI; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA., Boja ES; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA., Rodriguez H; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA., Chan DW; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA., Zhang B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Zhang Z; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA., Ding L; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Rodland KD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.; Lead Contact. |
مؤلفون مشاركون: | Clinical Proteomic Tumor Analysis Consortium |
المصدر: | Cell reports. Medicine [Cell Rep Med] 2020 Apr 21; Vol. 1 (1). Date of Electronic Publication: 2020 Apr 10. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2020]- |
مواضيع طبية MeSH: | Cystadenocarcinoma, Serous*/genetics , Cystadenocarcinoma, Serous*/metabolism , Cystadenocarcinoma, Serous*/mortality , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/mortality, Chromosomal Instability/*physiology , DNA Replication/*genetics , Phosphotransferases/*genetics, Adult ; Aged ; Aged, 80 and over ; Cell Cycle Checkpoints/genetics ; Cohort Studies ; DNA Damage ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/metabolism ; Fallopian Tube Neoplasms/mortality ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Mitosis/genetics ; Phosphotransferases/metabolism ; Proteogenomics ; Transcriptome ; Tumor Suppressor Protein p53/genetics |
مستخلص: | In the absence of a dominant driving mutation other than uniformly present TP53 mutations, deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) requires analysis at a functional level, including post-translational modifications. Comprehensive proteogenomic and phosphoproteomic characterization of 83 prospectively collected ovarian HGSC and appropriate normal precursor tissue samples (fallopian tube) under strict control of ischemia time reveals pathways that significantly differentiate between HGSC and relevant normal tissues in the context of homologous repair deficiency (HRD) status. In addition to confirming key features of HGSC from previous studies, including a potential survival-associated signature and histone acetylation as a marker of HRD, deep phosphoproteomics provides insights regarding the potential role of proliferation-induced replication stress in promoting the characteristic chromosomal instability of HGSC and suggests potential therapeutic targets for use in precision medicine trials. Competing Interests: DECLARATION OF INTERESTS The authors declare no competing interests. |
التعليقات: | Erratum in: Cell Rep Med. 2020 Aug 25;1(5):. (PMID: 32954372) |
References: | Oncoscience. 2019 Jan 31;6(1-2):287-288. (PMID: 30800714) Proc Natl Acad Sci U S A. 2013 May 28;110(22):8954-9. (PMID: 23671119) J Proteome Res. 2016 Mar 4;15(3):691-706. (PMID: 26653538) Genome Biol. 2011;12(4):R41. (PMID: 21527027) Bioinformatics. 2019 Mar 1;35(5):865-867. (PMID: 30102335) Genet Med. 2015 May;17(5):405-24. (PMID: 25741868) Nucleic Acids Res. 2008 Jan;36(Database issue):D695-9. (PMID: 17981841) J Proteome Res. 2017 Oct 6;16(10):3704-3710. (PMID: 28866885) Nucleic Acids Res. 2017 Jan 4;45(D1):D777-D783. (PMID: 27899578) Bioinformatics. 2017 Jun 26;33(21):3489-3491. (PMID: 28655153) Nature. 2014 Sep 18;513(7518):382-7. (PMID: 25043054) Nature. 2016 May 25;534(7605):55-62. (PMID: 27251275) Nat Rev Cancer. 2003 Feb;3(2):130-8. (PMID: 12563312) Nat Commun. 2014 Oct 31;5:5277. (PMID: 25358478) Nat Biotechnol. 2013 Mar;31(3):213-9. (PMID: 23396013) Cell Commun Signal. 2017 Oct 10;15(1):41. (PMID: 29017571) Nucleic Acids Res. 2001 Jan 1;29(1):308-11. (PMID: 11125122) J Proteome Res. 2008 Aug;7(8):3354-63. (PMID: 18597511) Cell Death Differ. 2014 Sep;21(9):1377-87. (PMID: 24926616) Nature. 2011 Jun 29;474(7353):609-15. (PMID: 21720365) Genome Biol. 2016 Jun 06;17(1):122. (PMID: 27268795) Exp Cell Res. 2014 Nov 15;329(1):85-93. (PMID: 25281304) OMICS. 2012 May;16(5):284-7. (PMID: 22455463) Genome Res. 2010 Sep;20(9):1297-303. (PMID: 20644199) Curr Opin Obstet Gynecol. 2017 Feb;29(1):26-34. (PMID: 27898521) Nat Commun. 2017 Oct 17;8(1):990. (PMID: 29042553) CA Cancer J Clin. 2018 Jan;68(1):7-30. (PMID: 29313949) Nucleic Acids Res. 2017 Jan 4;45(D1):D840-D845. (PMID: 27899611) Curr Biol. 2015 May 18;25(10):1327-33. (PMID: 25959964) Nucleic Acids Res. 2016 Jan 4;44(D1):D862-8. (PMID: 26582918) Nucleic Acids Res. 2012 Jan;40(Database issue):D261-70. (PMID: 22135298) Cell Rep. 2013 Sep 26;4(6):1116-30. (PMID: 24055055) Mutat Res. 2017 Oct;803-805:89-95. (PMID: 28552166) Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792) Cell. 2016 Jul 28;166(3):755-765. (PMID: 27372738) EMBO J. 1992 Nov;11(11):3995-4005. (PMID: 1396589) Curr Biol. 2005 Oct 11;15(19):1762-7. (PMID: 16213824) Sci Signal. 2013 Mar 26;6(268):rs6. (PMID: 23532336) Oncogene. 2006 Aug 28;25(38):5233-43. (PMID: 16936742) Mol Cell Proteomics. 2014 Jul;13(7):1690-704. (PMID: 24719451) Cell. 2016 Apr 21;165(3):535-50. (PMID: 27104977) BMC Med Genomics. 2014 Dec 03;7:64. (PMID: 25466818) Sci Rep. 2018 Jul 2;8(1):9930. (PMID: 29967321) Cell. 2019 Oct 31;179(4):964-983.e31. (PMID: 31675502) Comput Biol Chem. 2008 Jun;32(3):215-7. (PMID: 18440872) Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517) Bioinformatics. 2015 Dec 1;31(23):3838-40. (PMID: 26243018) Cell. 2018 Apr 5;173(2):355-370.e14. (PMID: 29625052) Cancers (Basel). 2019 Sep 19;11(9):. (PMID: 31546872) Mol Cancer Ther. 2018 Aug;17(8):1727-1738. (PMID: 29866747) Nat Biotechnol. 2006 Oct;24(10):1285-92. (PMID: 16964243) Future Oncol. 2016 Jan;12(2):221-37. (PMID: 26616915) Bioinformatics. 2009 Nov 1;25(21):2865-71. (PMID: 19561018) Nat Biotechnol. 2011 Jan;29(1):24-6. (PMID: 21221095) Cell. 2019 May 2;177(4):1035-1049.e19. (PMID: 31031003) Genome Res. 2012 Mar;22(3):568-76. (PMID: 22300766) Bioinformatics. 2014 Apr 1;30(7):1006-7. (PMID: 24351709) Int J Biochem Cell Biol. 2017 Oct;91(Pt B):102-115. (PMID: 28552434) Nat Commun. 2017 Oct 23;8(1):1093. (PMID: 29061967) Bioinformatics. 2012 Jul 15;28(14):1811-7. (PMID: 22581179) Cancers (Basel). 2018 Nov 12;10(11):. (PMID: 30424539) J Biol Chem. 1997 May 9;272(19):12738-46. (PMID: 9139732) Oncotarget. 2015 Jul 20;6(20):17873-90. (PMID: 26160835) Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20. (PMID: 23315928) Bioinformatics. 2008 Nov 1;24(21):2534-6. (PMID: 18606607) Nat Protoc. 2009;4(7):1073-81. (PMID: 19561590) Clin Cancer Res. 2019 Aug 15;25(16):5002-5014. (PMID: 30837276) |
معلومات مُعتمدة: | P41 GM103493 United States GM NIGMS NIH HHS; U24 CA160019 United States CA NCI NIH HHS; U24 CA160036 United States CA NCI NIH HHS; U24 CA210955 United States CA NCI NIH HHS |
المشرفين على المادة: | 0 (Tumor Suppressor Protein p53) EC 2.7.- (Phosphotransferases) |
تواريخ الأحداث: | Date Created: 20200613 Date Completed: 20220222 Latest Revision: 20220222 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7289043 |
DOI: | 10.1016/j.xcrm.2020.100004 |
PMID: | 32529193 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2666-3791 |
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DOI: | 10.1016/j.xcrm.2020.100004 |