دورية أكاديمية
C-peptide corrects hepatocellular dysfunction in a rat model of type 1 diabetes.
| العنوان: | C-peptide corrects hepatocellular dysfunction in a rat model of type 1 diabetes. |
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| المؤلفون: | Abdel-Hamid HA; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, Egypt. heba.abdelhameed@minia.edu.eg., Abdel-Hakeem EA; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, Egypt., Zenhom NM; Biochemistry Department, Faculty of Medicine, Minia University, Minia, Egypt., Toni NDM; Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt. |
| المصدر: | Journal of physiology and biochemistry [J Physiol Biochem] 2020 Aug; Vol. 76 (3), pp. 417-425. Date of Electronic Publication: 2020 Jun 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Servicio de Publicaciones de la Universidad De Navarra (departamentos de fisiología y nutrición y de bioquimica) Country of Publication: Spain NLM ID: 9812509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-8755 (Electronic) Linking ISSN: 11387548 NLM ISO Abbreviation: J Physiol Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Pamplona, Spain : Servicio de Publicaciones de la Universidad De Navarra (departamentos de fisiología y nutrición y de bioquimica), [1998- |
| مواضيع طبية MeSH: | C-Peptide/*therapeutic use , Diabetes Mellitus, Experimental/*drug therapy , Diabetes Mellitus, Type 1/*drug therapy , Liver/*drug effects, Animals ; Biomarkers/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Liver/pathology ; Male ; Rats ; Rats, Wistar ; Streptozocin |
| مستخلص: | C-peptide is gaining much interest recently due to its well-documented beneficial effects on multiple organ dysfunction induced by diabetes. Our study was designed to investigate the effect of C-peptide on hepatocellular dysfunction in diabetic rats. Wistar male rats were separated into four groups: control, diabetic, diabetic + insulin, and diabetic + C-peptide. Serum levels of glucose, insulin, and liver biomarkers were assessed. Liver sections were collected for histopathological examination and immuno-histochemical assessment of tumor necrosis factor alpha (TNF-α). Oxidative stress markers and gene expression of inducible nitric oxide synthase (iNOS), transforming growth factor beta 1 (TGF-β1), and glucose-6-phosphatase (G6Pase) were also measured in liver tissues. C-peptide administration prevented hepatic dysfunction induced by diabetes to a similar extent as that of insulin which was confirmed microscopically. We concluded that C-peptide could be used as an alternative therapy to insulin to correct hepatocellular dysfunction associated with type 1 diabetes mellitus (T1DM). |
| فهرسة مساهمة: | Keywords: C-peptide; Diabetes; Insulin; Liver; Rat |
| المشرفين على المادة: | 0 (Biomarkers) 0 (C-Peptide) 5W494URQ81 (Streptozocin) |
| تواريخ الأحداث: | Date Created: 20200613 Date Completed: 20210201 Latest Revision: 20210201 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s13105-020-00748-y |
| PMID: | 32529526 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1877-8755 |
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| DOI: | 10.1007/s13105-020-00748-y |