دورية أكاديمية
Bactericidal Effect of 5-Mercapto-2-nitrobenzoic Acid-Coated Silver Nanoclusters against Multidrug-Resistant Neisseria gonorrhoeae .
| العنوان: | Bactericidal Effect of 5-Mercapto-2-nitrobenzoic Acid-Coated Silver Nanoclusters against Multidrug-Resistant Neisseria gonorrhoeae . |
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| المؤلفون: | Lucío MI; Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton SO17 1BJ, U.K., Kyriazi ME; Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton SO17 1BJ, U.K., Hamilton J; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Batista D; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Sheppard A; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Sams-Dodd E; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Humbert MV; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Hussain I; Department of Chemistry & Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore Cantt 54792, Pakistan., Christodoulides M; Neisseria Research Laboratory, Molecular Microbiology, School of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K., Kanaras AG; Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton SO17 1BJ, U.K.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K. |
| المصدر: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Jun 24; Vol. 12 (25), pp. 27994-28003. Date of Electronic Publication: 2020 Jun 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*chemistry , Anti-Bacterial Agents/*pharmacology , Neisseria gonorrhoeae/*drug effects, Azithromycin/chemistry ; Azithromycin/pharmacology ; Ceftriaxone/chemistry ; Ceftriaxone/pharmacology ; Drug Resistance, Multiple, Bacterial ; Humans ; L-Lactate Dehydrogenase/metabolism ; Microbial Sensitivity Tests ; Silver Nitrate/chemistry ; Silver Nitrate/pharmacology |
| مستخلص: | Neisseria gonorrhoeae is among the most multidrug-resistant bacteria in circulation today, and new treatments are urgently needed. In this work, we demonstrate the ability of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters (MNBA-AgNCs) to kill strains of Neisseria gonorrhoeae . Using an in vitro bactericidal assay, MNBA-AgNCs had been found to show significantly higher anti-gonococcal bioactivity than the antibiotics ceftriaxone and azithromycin and silver nitrate. These nanoclusters were effective against both planktonic bacteria and a gonococcal infection of human cell cultures in vitro. Treatment of human cells in vitro with MNBA-AgNCs did not induce significant release of lactate dehydrogenase, suggesting minimal cytotoxicity to eukaryotic cells. Our results suggest that MNBA-AgNCs hold great potential for topical treatment of localized gonorrhoeae. |
| فهرسة مساهمة: | Keywords: Neisseria gonorrhoeae; antibacterial properties; azithromycin; ceftriaxone; human cells; nanoparticles; silver nanoclusters |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 75J73V1629 (Ceftriaxone) 83905-01-5 (Azithromycin) 95IT3W8JZE (Silver Nitrate) EC 1.1.1.27 (L-Lactate Dehydrogenase) |
| تواريخ الأحداث: | Date Created: 20200613 Date Completed: 20210301 Latest Revision: 20210301 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/acsami.0c06163 |
| PMID: | 32530591 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1944-8252 |
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| DOI: | 10.1021/acsami.0c06163 |