دورية أكاديمية
أعرض في EDS

Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies.

التفاصيل البيبلوغرافية
العنوان: Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies.
المؤلفون: Chen H; Center for Reproductive Sciences and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: hao.chen@ucsf.edu., Chidboy MA; Center for Reproductive Sciences and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: meganchidboy@berkeley.edu., Robinson JF; Center for Reproductive Sciences and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: joshua.robinson@ucsf.edu.
المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2020 Sep; Vol. 96, pp. 102-113. Date of Electronic Publication: 2020 Jun 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Elmsford Ny : Pergamon In Cooperation With The Reproductive Toxicology Center
Original Publication: Elmsford, N.Y., U.S.A. : Pergamon Press, c1987-
مواضيع طبية MeSH: Neurotoxicity Syndromes*/genetics, Embryonic Development/*drug effects , Retinoids/*toxicity, Adverse Outcome Pathways ; Animals ; Humans ; Toxicity Tests/methods ; Toxicogenetics
مستخلص: The use of genomic approaches in toxicological studies has greatly increased our ability to define the molecular profiles of environmental chemicals associated with developmental neurotoxicity (DNT). Integration of these approaches with adverse outcome pathways (AOPs), a framework that translates environmental exposures to adverse developmental phenotypes, can potentially inform DNT testing strategies. Here, using retinoic acid (RA) as a case example, we demonstrate that the integration of toxicogenomic profiles into the AOP framework can be used to establish a paradigm for chemical testing. RA is a critical regulatory signaling molecule involved in multiple aspects of mammalian central nervous system (CNS) development, including hindbrain formation/patterning and neuronal differentiation, and imbalances in RA signaling pathways are linked with DNT. While the mechanisms remain unresolved, environmental chemicals can cause DNT by disrupting the RA signaling pathway. First, we reviewed literature evidence of RA and other retinoid exposures and DNT to define a provisional AOP related to imbalances in RA embryonic bioavailability and hindbrain development. Next, by integrating toxicogenomic datasets, we defined a relevant transcriptomic signature associated with RA-induced developmental neurotoxicity (RA-DNT) in human and rodent models that was tested against zebrafish model data, demonstrating potential for integration into an AOP framework. Finally, we demonstrated how these approaches may be systematically utilized to identify chemical hazards by testing the RA-DNT signature against azoles, a proposed class of compounds that alters RA-signaling. The provisional AOP from this study can be expanded in the future to better define DNT biomarkers relevant to RA signaling and toxicity.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
References: Development. 2007 Jul;134(14):2673-84. (PMID: 17592014)
Development. 2012 Jun;139(12):2150-5. (PMID: 22619388)
J Neurosci. 2014 Nov 12;34(46):15223-33. (PMID: 25392491)
Reprod Toxicol. 2009 Nov;28(3):308-20. (PMID: 19447169)
Genes Dev. 2007 May 1;21(9):1113-24. (PMID: 17473173)
J Comp Neurol. 2002 Oct 21;452(3):228-41. (PMID: 12353219)
PLoS One. 2015 Sep 22;10(9):e0138588. (PMID: 26394147)
Nature. 1997 May 8;387(6629):191-5. (PMID: 9144291)
Reprod Toxicol. 2010 Sep;30(2):333-40. (PMID: 20488242)
Toxicol Lett. 2011 May 30;203(1):1-8. (PMID: 21362465)
Toxicol Sci. 2011 Dec;124(2):370-7. (PMID: 21934132)
Dev Dyn. 2013 Sep;242(9):1056-65. (PMID: 23765990)
Toxicol Sci. 2014 May;139(1):210-9. (PMID: 24496635)
Cell. 1993 Dec 17;75(6):1199-214. (PMID: 7903221)
Genes Dev. 2001 Jan 15;15(2):213-25. (PMID: 11157777)
Cell Mol Life Sci. 2015 Apr;72(8):1559-76. (PMID: 25558812)
Nature. 1987 Dec 3-9;330(6147):444-50. (PMID: 2825025)
Dev Biol. 2001 Jan 1;229(1):89-101. (PMID: 11133156)
Front Biosci. 2004 Jan 01;9:117-38. (PMID: 14766352)
Development. 2005 Jun;132(11):2611-22. (PMID: 15872003)
Birth Defects Res B Dev Reprod Toxicol. 2010 Feb;89(1):66-77. (PMID: 20166227)
Curr Opin Toxicol. 2018 Jun 01;9:1-7. (PMID: 29682628)
Development. 1995 Mar;121(3):681-91. (PMID: 7720576)
Biomolecules. 2019 Nov 24;9(12):. (PMID: 31771306)
J Mol Histol. 2004 Nov;35(8-9):823-7. (PMID: 15609095)
PLoS Biol. 2011 Apr;9(4):e1000609. (PMID: 21532733)
PLoS One. 2012;7(2):e30698. (PMID: 22319578)
Neuron. 2009 Jun 11;62(5):641-54. (PMID: 19524524)
Nat Rev Neurosci. 2007 Oct;8(10):755-65. (PMID: 17882253)
Development. 1993 Aug;118(4):1063-75. (PMID: 7903632)
Nature. 1996 Dec 19-26;384(6610):630-4. (PMID: 8967950)
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7772-6. (PMID: 8052659)
Nat Rev Neurosci. 2002 Nov;3(11):843-53. (PMID: 12415292)
Mol Neurobiol. 2016 Dec;53(10):6938-6949. (PMID: 26666665)
Stem Cell Res. 2018 Oct;32:25-34. (PMID: 30172094)
Development. 1997 Oct;124(19):3693-702. (PMID: 9367425)
Mech Dev. 2000 Jul;95(1-2):283-9. (PMID: 10906479)
Lancet. 2006 Dec 16;368(9553):2167-78. (PMID: 17174709)
Development. 1993 Oct;119(2):319-38. (PMID: 8287791)
Nutrients. 2011 Apr;3(4):385-428. (PMID: 22254103)
Development. 2007 Apr;134(7):1369-83. (PMID: 17329364)
FASEB J. 1996 Jul;10(9):1050-7. (PMID: 8801166)
Annu Rev Nutr. 2011 Aug 21;31:65-87. (PMID: 21529158)
Development. 1998 Dec;125(23):4739-48. (PMID: 9806922)
Toxicol Sci. 2018 Sep 1;165(1):21-30. (PMID: 29982830)
Annu Rev Cell Dev Biol. 2009;25:431-56. (PMID: 19575673)
Development. 1994 Oct;120(10):2723-48. (PMID: 7607067)
Cell. 1993 Jan 29;72(2):183-96. (PMID: 8093858)
Vitam Horm. 2007;75:97-115. (PMID: 17368313)
J Biol Chem. 2014 May 23;289(21):14868-80. (PMID: 24733397)
PLoS One. 2013 May 09;8(5):e63175. (PMID: 23671670)
Curr Opin Genet Dev. 2010 Aug;20(4):384-90. (PMID: 20537528)
PLoS One. 2009 Jun 10;4(6):e5845. (PMID: 19516907)
Neuron. 2016 Jul 6;91(1):79-89. (PMID: 27387650)
Exp Cell Res. 1999 Dec 15;253(2):737-46. (PMID: 10585298)
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158636. (PMID: 31978553)
Development. 2017 Feb 15;144(4):552-566. (PMID: 28196803)
Science. 1999 May 14;284(5417):1155-8. (PMID: 10325223)
Dev Dyn. 2007 Mar;236(3):644-53. (PMID: 17211890)
Toxicol In Vitro. 2008 Jun;22(4):1050-61. (PMID: 18289828)
Biomolecules. 2020 Jan 17;10(1):. (PMID: 31963453)
Development. 2001 Dec;128(23):4769-80. (PMID: 11731457)
Teratology. 1977 Feb;15(1):109-19. (PMID: 557242)
Eur J Neurosci. 2007 Jun;25(12):3526-36. (PMID: 17610572)
Birth Defects Res. 2018 Apr 3;110(6):502-518. (PMID: 29383852)
Development. 1991 Jan;111(1):245-52. (PMID: 1849811)
Toxicol Appl Pharmacol. 1996 Dec;141(2):456-72. (PMID: 8975771)
Development. 2004 Aug;131(16):4013-20. (PMID: 15269172)
Toxicol Appl Pharmacol. 2017 May 1;322:15-26. (PMID: 28263823)
Neurotoxicol Teratol. 1997 Sep-Oct;19(5):335-46. (PMID: 9380000)
Neuropharmacology. 2014 Mar;78:3-12. (PMID: 23270606)
Toxicol In Vitro. 1995 Jun;9(3):267-83. (PMID: 20650088)
Environ Health Perspect. 2009 Jan;117(1):17-25. (PMID: 19165382)
Mol Endocrinol. 2014 Feb;28(2):260-72. (PMID: 24422634)
J Med Primatol. 1998 Dec;27(6):310-8. (PMID: 10203012)
Dev Biol. 2004 Nov 1;275(1):124-42. (PMID: 15464577)
Development. 2002 Sep;129(18):4335-46. (PMID: 12183385)
Pharmacol Ther. 2017 May;173:19-33. (PMID: 28132904)
Development. 1991 Dec;113(4):1159-70. (PMID: 1811934)
Dev Biol. 2014 Nov 15;395(2):199-208. (PMID: 25251699)
Development. 2015 Apr 1;142(7):1212-27. (PMID: 25804734)
Development. 1996 Feb;122(2):543-54. (PMID: 8625806)
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5310-4. (PMID: 2546152)
Anal Chem. 2008 Mar 1;80(5):1702-8. (PMID: 18251521)
Reprod Toxicol. 2016 Apr;60:1-10. (PMID: 26827931)
Dev Dyn. 1997 May;209(1):92-104. (PMID: 9142499)
Toxicol Sci. 2011 Jan;119(1):126-34. (PMID: 20935163)
Exp Neurol. 2005 Aug;194(2):467-75. (PMID: 15893307)
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14349-54. (PMID: 9405615)
Neurotoxicology. 2017 Mar;59:240-255. (PMID: 27212452)
Nat Genet. 1999 Apr;21(4):444-8. (PMID: 10192400)
Curr Biol. 2013 Mar 4;23(5):412-8. (PMID: 23416099)
Development. 1995 Feb;121(2):539-48. (PMID: 7768191)
Toxicol Appl Pharmacol. 1995 Jan;130(1):9-18. (PMID: 7839374)
Mech Dev. 2002 Jan;110(1-2):165-71. (PMID: 11744377)
Cell. 1994 Dec 16;79(6):1025-34. (PMID: 8001130)
Reprod Toxicol. 2015 Aug 1;55:104-13. (PMID: 25461899)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Cell. 2008 Sep 19;134(6):921-31. (PMID: 18805086)
J Lipid Res. 2002 Nov;43(11):1773-808. (PMID: 12401878)
EMBO J. 2002 Feb 1;21(3):365-76. (PMID: 11823429)
Reprod Toxicol. 2006 Jan;21(1):74-82. (PMID: 16159706)
Development. 2019 Jul 4;146(13):. (PMID: 31273085)
Dev Biol. 2000 Apr 15;220(2):263-84. (PMID: 10753515)
Biol Chem. 2004 Jul;385(7):605-14. (PMID: 15318809)
ALTEX. 2011;28(1):9-15. (PMID: 21311847)
Development. 2003 Apr;130(7):1449-59. (PMID: 12588859)
Development. 1994 Aug;120(8):2199-211. (PMID: 7925021)
Elife. 2018 Oct 29;7:. (PMID: 30371350)
Reprod Toxicol. 2004 Jan-Feb;18(1):121-30. (PMID: 15013071)
Toxicol Appl Pharmacol. 2005 Jan 1;202(1):38-49. (PMID: 15589975)
Front Genet. 2012 Aug 07;3:141. (PMID: 22891073)
Genes Dev. 2001 Aug 15;15(16):2111-21. (PMID: 11511542)
Methods Enzymol. 2006;411:134-93. (PMID: 16939790)
Curr Top Dev Biol. 2009;88:103-37. (PMID: 19651303)
Nutr Rev. 1994 Feb;52(2 Pt 2):S32-44. (PMID: 8202281)
Development. 2000 Mar;127(5):933-44. (PMID: 10662633)
Heredity (Edinb). 2006 Aug;97(2):88-96. (PMID: 16721389)
Nature. 2007 Nov 15;450(7168):415-9. (PMID: 17928865)
J Biol Chem. 2000 Mar 10;275(10):6908-14. (PMID: 10702251)
Development. 1999 Feb;126(4):759-69. (PMID: 9895323)
Development. 1999 Mar;126(6):1317-26. (PMID: 10021349)
Development. 1996 Oct;122(10):3217-28. (PMID: 8898234)
Mech Dev. 2005 Feb;122(2):145-55. (PMID: 15652703)
Eur J Neurosci. 2003 Aug;18(3):457-72. (PMID: 12911743)
Reprod Toxicol. 2006 Aug;22(2):186-95. (PMID: 16781842)
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):895-905. (PMID: 20865785)
Teratology. 1988 Feb;37(2):113-25. (PMID: 3281303)
Development. 2012 Mar;139(5):843-58. (PMID: 22318625)
Development. 2000 Jan;127(1):75-85. (PMID: 10654602)
Nature. 1988 Apr 28;332(6167):850-3. (PMID: 2833708)
Cell. 2009 Oct 30;139(3):597-609. (PMID: 19879845)
Neurotoxicol Teratol. 1993 May-Jun;15(3):193-202. (PMID: 8336680)
Int Rev Cytol. 2001;209:1-77. (PMID: 11580199)
Eur J Neurosci. 1999 Feb;11(2):407-16. (PMID: 10051741)
Development. 2011 Jan;138(1):65-74. (PMID: 21098558)
Nat Rev Mol Cell Biol. 2015 Feb;16(2):110-23. (PMID: 25560970)
Toxicol Sci. 2012 Mar;126(1):242-54. (PMID: 22262565)
Dev Biol. 2010 Feb 1;338(1):1-14. (PMID: 19874812)
Genes Dev. 2001 Jan 15;15(2):226-40. (PMID: 11157778)
Semin Cell Dev Biol. 2011 Aug;22(6):603-10. (PMID: 21693195)
Neurobehav Toxicol Teratol. 1986 Nov-Dec;8(6):643-54. (PMID: 3808180)
Toxicol In Vitro. 2011 Apr;25(3):745-53. (PMID: 21238576)
Biochem J. 2005 May 15;388(Pt 1):363-9. (PMID: 15628969)
Development. 2014 Jan;141(1):158-65. (PMID: 24284210)
Toxicology. 2017 Dec 1;392:96-105. (PMID: 28970091)
Reprod Toxicol. 2016 Sep;64:77-85. (PMID: 27094377)
Annu Rev Pharmacol Toxicol. 1999;39:399-430. (PMID: 10331090)
Methods Mol Biol. 2013;947:451-73. (PMID: 23138921)
Curr Opin Genet Dev. 2000 Aug;10(4):380-6. (PMID: 10889064)
FASEB J. 2013 Dec;27(12):4877-89. (PMID: 24005908)
Genes Dev. 1992 Mar;6(3):329-44. (PMID: 1312497)
Development. 1991 Jan;111(1):45-60. (PMID: 1849812)
Dev Dyn. 1994 Jul;200(3):227-41. (PMID: 7949370)
Development. 2007 Jun;134(11):2147-58. (PMID: 17507415)
Development. 1998 Mar;125(6):1025-36. (PMID: 9463349)
Cell. 1993 May 21;73(4):643-58. (PMID: 8388780)
Toxicology. 2013 Oct 4;312:158-65. (PMID: 23978457)
ALTEX. 2018 Feb 23;35(3):306-352. (PMID: 29485663)
Nature. 1991 Oct 31;353(6347):861-4. (PMID: 1682814)
Science. 1998 Feb 6;279(5352):863-7. (PMID: 9452386)
Neurotoxicol Teratol. 1997 Sep-Oct;19(5):347-53. (PMID: 9380001)
Reprod Toxicol. 2012 Sep;34(2):275-83. (PMID: 22664269)
Dev Biol. 2005 Feb 15;278(2):415-27. (PMID: 15680360)
Teratology. 1972 Feb;5(1):103-18. (PMID: 5014447)
N Engl J Med. 1985 Oct 3;313(14):837-41. (PMID: 3162101)
Mol Cell. 2003 Jan;11(1):139-50. (PMID: 12535528)
J Biol Chem. 1994 Jun 17;269(24):16689-95. (PMID: 8206989)
Neuron. 1999 Apr;22(4):677-91. (PMID: 10230789)
Mech Dev. 1995 Jan;49(1-2):49-63. (PMID: 7748789)
J Biol Chem. 2009 Sep 11;284(37):24925-32. (PMID: 19556237)
Curr Opin Neurobiol. 2001 Feb;11(1):34-42. (PMID: 11179870)
معلومات مُعتمدة: K99 ES023846 United States ES NIEHS NIH HHS; K99 ES030401 United States ES NIEHS NIH HHS; R00 ES023846 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: Alternative model; Azoles; Embryonic stem cells; Human; In vitro; Neurogenesis; Neurotoxicity; Retinoic acid; Retinoids; Transcriptome; Whole embryo culture; Zebrafish
المشرفين على المادة: 0 (Retinoids)
تواريخ الأحداث: Date Created: 20200617 Date Completed: 20220308 Latest Revision: 20220308
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7736340
DOI: 10.1016/j.reprotox.2020.06.007
PMID: 32544423
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1708
DOI:10.1016/j.reprotox.2020.06.007