تقرير
Transmission of cryptococcosis by liver transplantation: A case report and review of literature.
| العنوان: | Transmission of cryptococcosis by liver transplantation: A case report and review of literature. |
|---|---|
| المؤلفون: | Ferreira GSA; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil. gustferr@ufmg.br., Watanabe ALC; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil., Trevizoli NC; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil., Jorge FMF; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil., Couto CF; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil., de Campos PB; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil., Caja GON; Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil. |
| المصدر: | World journal of hepatology [World J Hepatol] 2020 May 27; Vol. 12 (5), pp. 253-261. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101532469 Publication Model: Print Cited Medium: Print ISSN: 1948-5182 (Print) NLM ISO Abbreviation: World J Hepatol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Baishideng |
| مستخلص: | Background: Cryptococcosis is a fungal infection caused by the yeast-like encapsulated basidiomycetous fungus of the Cryptococcus neoformans ( C. neoformans ) species complex. These fungi are ubiquitous in soil and bird droppings, and infection by them is an important global health concern, particularly in immunosuppressed patients, such as organ transplant recipients and those infected by the human immunodeficiency virus. The fungus usually enters the body through the respiratory tract, but extremely rare cases of infection acquired by transplantation of solid organs have been reported. Case Summary: We report a case of disseminated cryptococcosis in a liver transplant recipient, diagnosed 2 wk after the procedure. The patient initially presented with fever, hyponatremia and elevated transaminase levels, manifesting intense headache after a few days. Blood cultures were positive for C. neoformans . Liver biopsy showed numerous fungal elements surrounded by gelatinous matrix and sparse granulomatous formations. Magnetic resonance imaging of the brain showed multiple small lesions with low signal in T2, peripheric enhancement and edematous halo, diffuse through the parenchyma but more concentrated in the subcortical regions. Treatment with amphotericin B for 3 wk, followed by maintenance therapy with fluconazole, led to complete resolution of the symptoms. The recipients of both kidneys from the same donor also developed disseminated cryptococcosis, confirming the transplant as the source of infection. The organ donor lived in a rural area, surrounded by tropical rainforest, and had negative blood cultures prior to organ procurement. Conclusion: This case highlights the risk of transmission of fungal diseases, specifically of C. neoformans , through liver graft during liver transplantation. Competing Interests: Conflict-of-interest statement: The authors declare no conflicts of interest. (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| References: | Braz J Infect Dis. 2018 Nov - Dec;22(6):495-498. (PMID: 30508502) Medicine (Baltimore). 1996 May;75(3):142-56. (PMID: 8965683) Med Mycol. 2010 Sep;48(6):785-91. (PMID: 20100136) Clin Infect Dis. 2000 Apr;30(4):710-8. (PMID: 10770733) Liver Transpl. 2010 Apr;16(4):499-502. (PMID: 20373460) Transpl Infect Dis. 2005 Mar;7(1):1-3. (PMID: 15984941) Transplantation. 1971 Apr;11(4):428-9. (PMID: 4934356) J Assoc Physicians India. 2016 Oct;64(10):15-19. (PMID: 27766797) Indian J Nephrol. 2017 Sep-Oct;27(5):392-394. (PMID: 28904437) Liver Transpl. 2008 Sep;14(9):1249-55. (PMID: 18756456) Clin Infect Dis. 2008 Jan 15;46(2):e12-8. (PMID: 18171241) Cornea. 2005 Oct;24(7):882-3. (PMID: 16160511) Clin Infect Dis. 2006 May 15;42(10):1443-7. (PMID: 16619158) Clin Infect Dis. 2011 Feb 15;52(4):e94-8. (PMID: 21220771) PLoS One. 2015 Mar 06;10(3):e0119090. (PMID: 25747471) Clin Kidney J. 2013 Apr;6(2):224-7. (PMID: 26019853) Emerg Infect Dis. 2001 May-Jun;7(3):375-81. (PMID: 11384512) Int J Infect Dis. 2014 Sep;26:154-61. (PMID: 25063020) Curr Opin Organ Transplant. 2017 Aug;22(4):307-313. (PMID: 28562416) Emerg Microbes Infect. 2019;8(1):119-129. (PMID: 30866766) Clin Infect Dis. 2010 Nov 1;51(9):1062-9. (PMID: 20879857) N Engl J Med. 1978 Apr 13;298(15):825-6. (PMID: 345120) Transplantation. 2012 Jan 15;93(1):17-21. (PMID: 22015465) Rev Inst Med Trop Sao Paulo. 2003 Nov-Dec;45(6):299-305. (PMID: 14762626) Antimicrob Agents Chemother. 2008 Feb;52(2):735-8. (PMID: 18070977) Transplant Proc. 2016 Sep;48(7):2289-2293. (PMID: 27742281) Transplantation. 2010 Jan 15;89(1):69-74. (PMID: 20061921) Kidney Int. 1993 Jul;44(1):221-36. (PMID: 8394951) Transpl Int. 1998;11(1):63-5. (PMID: 9503557) BMC Vet Res. 2017 Feb 7;13(1):41. (PMID: 28173801) Clin Infect Dis. 2008 Nov 15;47(10):1321-7. (PMID: 18840080) Rev Soc Bras Med Trop. 2008 Sep-Oct;41(5):524-44. (PMID: 19009203) Am J Transplant. 2009 Aug;9(8):1929-35. (PMID: 19538493) Mem Inst Oswaldo Cruz. 2008 Dec;103(8):813-8. (PMID: 19148422) Transpl Infect Dis. 2009 Apr;11(2):179-82. (PMID: 19210677) Hepat Mon. 2015 Sep 27;15(9):e29902. (PMID: 26504469) Clin Transplant. 2019 Sep;33(9):e13543. (PMID: 30900315) Infect Dis Clin North Am. 2016 Mar;30(1):179-206. (PMID: 26897067) Yeast. 2014 Feb;31(2):47-60. (PMID: 24375706) Am J Transplant. 2002 Aug;2(7):575-80. (PMID: 12201357) Open Forum Infect Dis. 2017 Jan 12;4(1):ofx004. (PMID: 28480277) Am J Med. 2006 Feb;119(2):169-71. (PMID: 16443429) N Engl J Med. 2013 Apr 4;368(14):1291-1302. (PMID: 23550668) Exp Clin Transplant. 2014 Feb;12(1):74-7. (PMID: 23901902) |
| فهرسة مساهمة: | Keywords: Case report; Cryptococcosis; Cryptococcus neoformans; Fungal infection; Immunosuppression; Liver transplantation |
| تواريخ الأحداث: | Date Created: 20200618 Latest Revision: 20200928 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7280860 |
| DOI: | 10.4254/wjh.v12.i5.253 |
| PMID: | 32547692 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-5182 |
|---|---|
| DOI: | 10.4254/wjh.v12.i5.253 |