دورية أكاديمية
Pyramid-Shaped PEG-PCL-PEG Polymeric-Based Model Systems for Site-Specific Drug Delivery of Vancomycin with Enhance Antibacterial Efficacy.
العنوان: | Pyramid-Shaped PEG-PCL-PEG Polymeric-Based Model Systems for Site-Specific Drug Delivery of Vancomycin with Enhance Antibacterial Efficacy. |
---|---|
المؤلفون: | Singh S; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa., Alrobaian MM; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21974, Kingdom of Saudi Arabia., Molugulu N; School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia., Agrawal N; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa., Numan A; State Key Laboratory of ASIC and System, SIST, Fudan University, 200433 Shanghai, China., Kesharwani P; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, 110062 New Delhi, India. |
المصدر: | ACS omega [ACS Omega] 2020 May 18; Vol. 5 (21), pp. 11935-11945. Date of Electronic Publication: 2020 May 18 (Print Publication: 2020). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society, [2016]- |
مستخلص: | Antibacterial resistance remains a major global problem due to frequent prescriptions, leading to significant toxicities. To overcome the limitations of antibiotic therapy, it is highly desirable to provide site-specific delivery of drugs with controlled release. Inspired by the biocompatible, biodegradable, and site-specific mimicking behavior of poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL), we developed vancomycin-PEG-PCL-PEG conjugates to maximize the pharmacological effects and minimize the side effects. Drug-loaded vancomycin-PEG-PCL-PEG conjugates are influenced by size, shape, surface area, encapsulation efficiency, in vitro drug release, hemolysis assay, cytotoxicity, and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and bacterial kill kinetics. The results demonstrated that vancomycin (VCM) release from PEG-PCL-PEG triblock revealed a biphasic manner. Hemolysis assay showed the nonprescription nature of VCM-PEG-PCL-PEG. Cytotoxicity studies confirmed the biocompatibility of VCM-PEG-PCL-PEG. The in vitro antibacterial results showed enhance activity with minimum inhibitory concentration compared to bare VCM. Molecular dynamics simulation study revealed that binding between VCM and PEG-PCL-PEG by hydrophobic interactions offers molecular encapsulation and steric barrier to drug degradation. This newly developed therapeutic delivery system can offer to enhance activity and delivery VCM against MRSA. Competing Interests: The authors declare no competing financial interest. (Copyright © 2020 American Chemical Society.) |
التعليقات: | Erratum in: ACS Omega. 2022 Oct 17;7(43):39471. (PMID: 36340148) |
References: | ACS Omega. 2017 Sep 30;2(9):5364-5369. (PMID: 30023747) Int J Pharm. 2009 Jan 5;365(1-2):89-99. (PMID: 18793709) Sci Rep. 2016 May 05;6:25518. (PMID: 27145858) J Colloid Interface Sci. 2019 Jul 1;547:40-49. (PMID: 30939343) J Comput Chem. 2010 Mar;31(4):671-90. (PMID: 19575467) Toxicol Sci. 2005 Dec;88(2):412-9. (PMID: 16014736) J Med Chem. 1999 Nov 4;42(22):4714-9. (PMID: 10579833) J Hosp Infect. 2011 Nov;79(3):189-93. (PMID: 21741111) Klin Mikrobiol Infekc Lek. 2018 Jun;24(2):50-56. (PMID: 30747432) J Colloid Interface Sci. 2019 Jan 1;533:13-23. (PMID: 30144689) Clin Infect Dis. 2009 Jul 1;49(1):1-45. (PMID: 19489710) Microb Drug Resist. 2017 Mar;23(2):241-246. (PMID: 27754770) J Chem Inf Model. 2014 Jul 28;54(7):1951-62. (PMID: 24850022) ACS Chem Neurosci. 2016 Oct 19;7(10):1433-1441. (PMID: 27454141) J Chem Phys. 2007 Nov 14;127(18):184102. (PMID: 18020625) Biomaterials. 2013 Dec;34(38):10238-48. (PMID: 24070569) Artif Cells Nanomed Biotechnol. 2018;46(sup1):938-945. (PMID: 29468888) Int J Nanomedicine. 2015 Nov 23;10:7175-82. (PMID: 26648721) J Biomed Mater Res B Appl Biomater. 2008 Jan;84(1):165-75. (PMID: 17455282) Clin Infect Dis. 2014 Jan;58 Suppl 1:S10-9. (PMID: 24343827) Sci Rep. 2017 Jun 19;7(1):3827. (PMID: 28630477) ACS Appl Mater Interfaces. 2015 Apr 1;7(12):6966-73. (PMID: 25762191) J Chem Phys. 2007 Jan 7;126(1):014101. (PMID: 17212484) Chem Mater. 2012 Mar 13;24(5):840-853. (PMID: 22707853) |
تواريخ الأحداث: | Date Created: 20200618 Latest Revision: 20221107 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7271022 |
DOI: | 10.1021/acsomega.9b04064 |
PMID: | 32548372 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2470-1343 |
---|---|
DOI: | 10.1021/acsomega.9b04064 |