دورية أكاديمية
Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation.
| العنوان: | Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation. |
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| المؤلفون: | Linares GR; Molecular Neurobiology Section, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at University of Southern California, Los Angeles, California., Leng Y; Molecular Neurobiology Section, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Maric D; Flow and Imaging Cytometry Core Facility, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland., Chuang DM; Molecular Neurobiology Section, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland. |
| المصدر: | Cell biology international [Cell Biol Int] 2020 Oct; Vol. 44 (10), pp. 2163-2169. Date of Electronic Publication: 2020 Jul 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Chichester Country of Publication: England NLM ID: 9307129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8355 (Electronic) Linking ISSN: 10656995 NLM ISO Abbreviation: Cell Biol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : John Wiley & Sons Chichester : Original Publication: London, UK : Published for the International Federation for Cell Biology by Academic Press, c1993- |
| مواضيع طبية MeSH: | Apoptosis* , Inflammation* , Oxidative Stress*, Fibroblast Growth Factors/*physiology , Mesenchymal Stem Cells/*cytology, Animals ; Cells, Cultured ; Hydrogen Peroxide/pharmacology ; Mice ; Mice, Inbred C57BL ; Staurosporine/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology |
| مستخلص: | The clinical application of stem cells offers great promise as a potential avenue for therapeutic use in neurodegenerative diseases. However, cell loss after transplantation remains a major challenge, which currently plagues the field. On the basis of our previous findings that fibroblast growth factor 21 (FGF-21) protected neurons from glutamate excitotoxicity and that upregulation of FGF-21 in a rat model of ischemic stroke was associated with neuroprotection, we proposed that overexpression of FGF-21 protects bone marrow-derived mesenchymal stem cells (MSCs) from apoptosis. To test this hypothesis, we examined whether the detrimental effects of apoptosis can be mitigated by the transgenic overexpression of FGF-21 in MSCs. FGF-21 was transduced into MSCs by lentivirus and its overexpression was confirmed by quantitative polymerase chain reaction. Moreover, FGF-21 overexpression did not stimulate the expression of other FGF family members, suggesting it does not activate a positive feedback system. The effects of hydrogen peroxide (H (© 2020 International Federation for Cell Biology.) |
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| معلومات مُعتمدة: | Z01 MH002468 United States ImNIH Intramural NIH HHS; Z99 MH999999 United States ImNIH Intramural NIH HHS; ZIA MH002468 United States ImNIH Intramural NIH HHS; 1ZIAMH002468-25 United States MH NIMH NIH HHS |
| فهرسة مساهمة: | Keywords: TNF-α; caspase activation; hydrogen peroxide; oxidative stress |
| المشرفين على المادة: | 0 (Tumor Necrosis Factor-alpha) 0 (fibroblast growth factor 21) 62031-54-3 (Fibroblast Growth Factors) BBX060AN9V (Hydrogen Peroxide) H88EPA0A3N (Staurosporine) |
| تواريخ الأحداث: | Date Created: 20200620 Date Completed: 20210810 Latest Revision: 20240211 |
| رمز التحديث: | 20240211 |
| مُعرف محوري في PubMed: | PMC10848314 |
| DOI: | 10.1002/cbin.11409 |
| PMID: | 32557962 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-8355 |
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| DOI: | 10.1002/cbin.11409 |