دورية أكاديمية
أعرض في EDS

Long-term Consequences of Undiagnosed Celiac Seropositivity.

التفاصيل البيبلوغرافية
العنوان: Long-term Consequences of Undiagnosed Celiac Seropositivity.
المؤلفون: Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Skaaby T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Petersen J; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Madsen AL; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Schwarz P; Department of Endocrinology and Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rumessen JJ; Q&D-Research Unit and Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
المصدر: The American journal of gastroenterology [Am J Gastroenterol] 2020 Oct; Vol. 115 (10), pp. 1681-1688.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 0421030 Publication Model: Print Cited Medium: Internet ISSN: 1572-0241 (Electronic) Linking ISSN: 00029270 NLM ISO Abbreviation: Am J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019-> : [Philadelphia, PA] : Wolters Kluwer Health
Original Publication: New York, Elsevier Science, -2003.
مواضيع طبية MeSH: Mortality*, Cardiovascular Diseases/*epidemiology , Celiac Disease/*epidemiology , Neoplasms/*epidemiology , Undiagnosed Diseases/*epidemiology, Adolescent ; Adult ; Aged ; Antibodies/immunology ; Autoantibodies/immunology ; Biological Specimen Banks ; Breast Neoplasms/epidemiology ; Celiac Disease/immunology ; Denmark/epidemiology ; Female ; GTP-Binding Proteins/immunology ; Gastrointestinal Neoplasms/epidemiology ; Gliadin/immunology ; Head and Neck Neoplasms/epidemiology ; Humans ; Immunoglobulin A/immunology ; Immunoglobulin G/immunology ; Incidence ; Male ; Middle Aged ; Prevalence ; Proportional Hazards Models ; Protein Glutamine gamma Glutamyltransferase 2 ; Risk Factors ; Transglutaminases/immunology ; Uterine Neoplasms/epidemiology ; Young Adult
مستخلص: Introduction: Diagnosed celiac disease (CD) is associated with lymphoproliferative malignancy and gastrointestinal cancer, but little is known about the long-term consequences of undiagnosed CD. We aimed to investigate long-term consequences of undiagnosed CD for mortality and incidence of cancer and other chronic diseases.
Methods: We screened biobank serum samples for immunoglobulin (Ig) A and IgG tissue transglutaminase (TTG) and IgG deamidated gliadin peptide in a study of 8 population-based cohort studies comprising 16,776 participants examined during 1976-2012 and followed with >99% complete follow-up in Danish nationwide registries until December 31, 2017, regarding vital status and incidence of diseases. Undiagnosed CD was defined as antibody positivity (IgA-TTG or IgG-TTG ≥ 7 U/mL and/or IgG deamidated gliadin peptide ≥ 10 U/mL) in individuals without a diagnosis of CD recorded in the National Patient Register. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated by Cox regression analyses with age as the underlying time scale.
Results: The prevalence of undiagnosed CD was 1.0% with no statistically significant increase over time. Undiagnosed CD was associated with increased risk of cancer overall (HR, 1.57; 95% CI, 1.16-2.11), gastrointestinal cancer (HR, 2.33; 95% CI, 1.35-4.04), cancer of the uterus (HR, 3.95; 95% CI, 1.46-10.69), breast cancer (HR, 1.98; 95% CI, 1.02-3.82), head and neck cancer (HR, 3.12; 95% CI, 1.15-8.43), and cardiovascular disease (HR, 1.37; 95% CI, 1.01-1.85). We found no statistically significant association between undiagnosed CD and mortality (HR, 1.19; 95% CI, 0.87-1.61).
Discussion: Undiagnosed CD was associated with increased risk of cardiovascular disease and cancer suggesting that untreated CD has serious long-term health consequences not only affecting the gastrointestinal tract (see Visual Abstract, Supplementary Digital Content, http://links.lww.com/AJG/B566).
التعليقات: Comment in: Am J Gastroenterol. 2021 Jul 1;116(7):1552. (PMID: 33811200)
Comment in: Am J Gastroenterol. 2021 Jul 1;116(7):1551-1552. (PMID: 34183580)
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المشرفين على المادة: 0 (Antibodies)
0 (Autoantibodies)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
9007-90-3 (Gliadin)
EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
EC 2.3.2.13 (Transglutaminases)
EC 3.6.1.- (GTP-Binding Proteins)
تواريخ الأحداث: Date Created: 20200620 Date Completed: 20201123 Latest Revision: 20211204
رمز التحديث: 20231215
DOI: 10.14309/ajg.0000000000000737
PMID: 32558687
قاعدة البيانات: MEDLINE
الوصف
تدمد:1572-0241
DOI:10.14309/ajg.0000000000000737