دورية أكاديمية
The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines.
| العنوان: | The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines. |
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| المؤلفون: | Deijns SJ; University Medical Centre Utrecht and Utrecht University, Utrecht 3584 CX, the Netherlands., Broen JCA; Regional Rheumatology Centre, Máxima Medical Centre, 5631 BM Eindhoven and 5504 DB, Veldhoven, the Netherlands., Kruyt ND; Department of Neurology, Leiden University Medical Centre, Leiden 2333 ZA, the Netherlands. Electronic address: n.d.kruyt@lumc.nl., Schubart CD; Department of Psychiatry, Tergooi Ziekenhuis, 1261 AN Blaricum, Hilversum 1213 XZ, the Netherlands. Electronic address: CSchubart@tergooi.nl., Andreoli L; Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, BS 25123, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, BS 25123, Italy. Electronic address: Laura.Andreoli@unibs.it., Tincani A; Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, BS 25123, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, BS 25123, Italy; I.M. Sechenov First Moscow State Medical University, Moscow, Russia. Electronic address: Angela.Tincani@unibs.it., Limper M; Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584 CX, the Netherlands. Electronic address: M.Limper-2@umcutrecht.nl. |
| المصدر: | Autoimmunity reviews [Autoimmun Rev] 2020 Aug; Vol. 19 (8), pp. 102592. Date of Electronic Publication: 2020 Jun 17. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | Antibodies*/immunology , Blood-Brain Barrier*/immunology , Cytokines*/immunology , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/immunology , Mental Disorders*/etiology , Mental Disorders*/immunology, Chemokines/immunology ; Humans |
| مستخلص: | Introduction: The aim of this narrative review is to provide an overview of the literature on the possible immunologic pathophysiology of psychiatric manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods: A systematic search on PubMed was conducted. English studies with full text availability that investigated the correlation between blood-brain barrier (BBB) dysfunction, intrathecal synthesis of antibodies, antibodies, cytokines, chemokines, metalloproteinases, complement and psychiatric NPSLE manifestations in adults were included. Results: Both transient BBB-dysfunction with consequent access of antibodies to the cerebrospinal fluid (CSF) and intrathecal synthesis of antibodies could occur in psychiatric NPSLE. Anti-phospholipid antibodies, anti-NMDA antibodies and anti-ribosomal protein p antibodies seem to mediate concentration dependent neuronal dysfunction. Interferon-α may induce microglial engulfment of neurons, direct neuronal damage and production of cytokines and chemokines in psychiatric NPSLE. Several cytokines, chemokines and matrix metalloproteinase-9 may contribute to the pathophysiology of psychiatric NPSLE by attracting and activating Th1-cells and B-cells. Discussion: This potential pathophysiology may help understand NPSLE and may have implications for the diagnostic management and therapy of psychiatric NPSLE. However, the presented pathophysiological model is based on correlations between potential immunologic etiologies and psychiatric NPSLE that remain questionable. More research on this topic is necessary to further elucidate the pathophysiology of NPSLE. Competing Interests: Declaration of Competing Interest No conflicts of interest were stated. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antibody; Blood-brain barrier; Chemokine; Cytokine; Neuropsychiatric systemic lupus erythematosus; Psychiatric |
| المشرفين على المادة: | 0 (Antibodies) 0 (Chemokines) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20200621 Date Completed: 20200827 Latest Revision: 20200827 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.autrev.2020.102592 |
| PMID: | 32561462 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-0183 |
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| DOI: | 10.1016/j.autrev.2020.102592 |