دورية أكاديمية
Posterior Oropharyngeal Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
| العنوان: | Posterior Oropharyngeal Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). |
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| المؤلفون: | Wong SCY; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong.; Infection Control Team, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Tse H; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, Hong Kong., Siu HK; Infection Control Team, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Kwong TS; Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Chu MY; Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Yau FYS; Department of Pediatrics, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Cheung IYY; Department of Pathology, Kwong Wah Hospital, Hong Kong Special Administrative Region, Hong Kong., Tse CWS; Department of Pathology, Kwong Wah Hospital, Hong Kong Special Administrative Region, Hong Kong., Poon KC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Cheung KC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Wu TC; Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Chan JWM; Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Cheuk W; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong., Lung DC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, Hong Kong.; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, Hong Kong. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 Dec 31; Vol. 71 (11), pp. 2939-2946. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | COVID-19* , SARS-CoV-2*, Clinical Laboratory Techniques ; Humans ; Pandemics ; Retrospective Studies ; Saliva |
| مستخلص: | Background: The coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on the healthcare system worldwide. Diagnostic testing remained one of the limiting factors for early identification and isolation of infected patients. This study aimed to evaluate posterior oropharyngeal saliva (POPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection among patients with confirmed or suspected COVID-19. Methods: The laboratory information system was searched retrospectively for all respiratory specimens and POPS requested for SARS-CoV-2 RNA detection between 1 February 2020 and 15 April 2020. The agreement and diagnostic performance of POPS against NPsp were evaluated. Results: A total of 13772 specimens were identified during the study period, including 2130 POPS and 8438 nasopharyngeal specimens (NPsp). Two hundred and twenty-nine same-day POPS-NPsp paired were identified with POPS and NPsp positivity of 61.5% (95% confidence interval [CI] 55.1-67.6%) and 53.3% (95% CI 46.8-59.6%). The overall, negative and positive percent agreement were 76.0% (95% CI 70.2-80.9%), 65.4% (95% CI 55.5-74.2%), 85.2% (95% CI 77.4-90.8%). Better positive percent agreement was observed in POPS-NPsp obtained within 7 days (96.6%, 95% CI 87.3-99.4%) compared with after 7 days of symptom onset (75.0%, 95% CI 61.4-85.2%). Among the 104 positive pairs, the mean difference in Cp value was 0.26 (range: 12.63 to -14.74), with an overall higher Cp value in NPsp (Pearson coefficient 0.579). No significant temporal variation was noted between the 2 specimen types. Conclusions: POPS is an acceptable alternative specimen to nasopharyngeal specimen for the detection of SARS-CoV-2. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.) |
| التعليقات: | Comment in: Clin Infect Dis. 2021 Aug 2;73(3):555-557. (PMID: 32770241) |
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| فهرسة مساهمة: | Keywords: COVID-19; mass screening; pandemic; saliva; severe acute respiratory syndrome coronavirus 2 |
| تواريخ الأحداث: | Date Created: 20200621 Date Completed: 20210106 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7337706 |
| DOI: | 10.1093/cid/ciaa797 |
| PMID: | 32562544 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciaa797 |