دورية أكاديمية
أعرض في EDS

GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells.

التفاصيل البيبلوغرافية
العنوان: GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells.
المؤلفون: Lisse TS; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA.; Department of Biology, The University of Miami, 1301 Memorial Drive, Cox Science Building, Coral Gables, FL 33124 USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33146 USA., Sharma M; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA., Vishlaghi N; Department of Biology, The University of Miami, 1301 Memorial Drive, Cox Science Building, Coral Gables, FL 33124 USA., Pullagura SR; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, 04469 ME USA., Braun RE; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, 04469 ME USA.
المصدر: NPJ Regenerative medicine [NPJ Regen Med] 2020 Jun 12; Vol. 5, pp. 13. Date of Electronic Publication: 2020 Jun 12 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group, published in partnership with Monash University and Australian Regenerative Medicine Institute Country of Publication: United States NLM ID: 101699846 Publication Model: eCollection Cited Medium: Internet ISSN: 2057-3995 (Electronic) Linking ISSN: 20573995 NLM ISO Abbreviation: NPJ Regen Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Nature Publishing Group, published in partnership with Monash University and Australian Regenerative Medicine Institute, [2016]-
مستخلص: Glial-cell-derived neurotrophic factor (GDNF) is a well-studied neuroregenerative factor; however, the degree to which it supports hair formation and skin wound repair is not known. By using a Gfra1 (GDNF family receptor alpha 1) knock-in reporter mouse line, GDNF signaling was found to occur within hair bulge stem cells (BSCs) during the initiation of the hair cycle and early stages of hair formation after depilation. Both recombinant and transgene overexpression of GDNF promoted BSC colony growth, hair formation, and skin repair after wounding through enhanced self-renewal of BSCs and commitment of BSC-derived progenitors into becoming epidermal cells at the injury site. Conditional ablation of Gfra1 among BSCs impaired the onset of the hair cycle, while conditional ablation of the GDNF family member signal transducer, Ret , within BSCs prevented the onset of the hair cycle and depilation-induced anagen development of hair follicles. Our findings reveal that GDNF promotes hair formation and wound repair and that bulge stem cells are critical mediators of both.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2020.)
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معلومات مُعتمدة: P20 GM103423 United States GM NIGMS NIH HHS; P30 CA034196 United States CA NCI NIH HHS; U54 HD042454 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: Skin stem cells; Stem-cell niche
تواريخ الأحداث: Date Created: 20200623 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC7293257
DOI: 10.1038/s41536-020-0098-z
PMID: 32566252
قاعدة البيانات: MEDLINE
الوصف
تدمد:2057-3995
DOI:10.1038/s41536-020-0098-z